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Biomedical subjects

A G STEINBERG

Publications and source records attributed to A G STEINBERG.

At least 19 recordsLinked to original sources
PubMed1964

DEPENDENCE OF A GM(B) ANTIGEN ON THE QUATERNARY STRUCTURE OF HUMAN GAMMA GLOBULIN.

The antigens associated with the Gm(b) factor of human 7S gamma-globulin differ in Caucasoids and Negroids. The studies reported here show that an antigen, Gm(b(w)), associated with the Gm(b) of whites but not with that of Negroes, is present on the S (slow) fragment of 7S gamma-globulin obtained by digestion with papain or pepsin. All other Gm antigens thus far studied have been found on the F (fast) fragment. The antigens Inv(a) and Inv(b) were detected on isolated L-chains, and Gm(a) and Gm(b) were detected on isolated H-chains, but Gm(b(w)) was detected on neither. Recombining the H- and L-chains restored activity for Gm(b(w)) comparable to that of intact gamma-globulin

Antigens↗
PubMed1963

Hereditary globulin factors and immune tolerance in man.

Eight nontransfused donors of antibodies against a hereditary gamma-globulin factor lacked the factor, but each donor's mother had it. The probability that this is a chance observation is .00003. A ninth donor had been transfused, and she and her mother both lacked the factor. It is assumed that each nontransfused donor's antibody was formed against his mother's gamma-globulin and that immune tolerance had not been induced.

Antibodies↗