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Biomedical subjects

A G Secchi

Publications and source records attributed to A G Secchi.

At least 55 records · Page 3Linked to original sources
PubMed1979

Opto-chiasmatic arachnoiditis: a review of traditional neuroradiological diagnosis (82 cases, 1951--1976).

A retrospective appraisal of traditional neuroradiological techniques (such as direct röntgenograms, cerebral angiography RISA-cisternography, and pneumo-cisterno-encephalography, as opposed to the "new" technique of computer-assisted tomography) was carried out in a series of 82 cases of opto-chiasmatic arachnoiditis, all surgically verified. It is concluded that none of these examinations can provide a reliable diagnosis of opto-chiasmatic arachnoiditis, which preoperatively can only be a tentative diagnosis that becomes final only when confirmed by surgical findings. In the presence of certain progressive neuro-ophthalmological symptoms and signs, a negative neuro-radiological investigation should not deter the neurosurgeon from exploring the chiasmatic region. Computer-assisted tomography, of which the authors have no personal experience in these cases, may hold the future answer to the diagnostic problem.

Arachnoid↗
PubMed1979

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

Phospholipase A and lysophosphatidyl choline (LPC) have been shown to induce significant changes in the lens permeability in vitro to cations and soluble proteins. During uveal inflammation, in various experimental models and in man as well, the levels of LPC in the aqueous humour have been shown to reach values which are harmful to the lens in vitro. In addition, a phospholipase is thought to be activated during the antigen + antibody + complement sequence. The possible significance of these findings is discussed in relation to the pathogenesis of complicated cataracts in uveitis and the possible role of the lens as a source of autoantigens in recurrent uveitis.

Animals↗
PubMed1978

Immunopathology of the lens. II. 86Rb efflux and protein leakage from normal lenses exposed to antilens and antiuveoretina antibodies.

Normal rabbit lenses exposed in vitro to heterologous antilens and antiuveoretina antibodies lose control of the intracellular 86Rb and this effect is followed by a late leakage of lenticular proteins; both phenomena take place only in the presence of complement. This antibody-induced complement-dependent membrane damage might be involved in the pathogenesis of complicated cataracts in uveitis and in the self-maintenance of recurrent uveal inflammations.

Animals↗
PubMed1977

Immunopathology of the lens. I 86Rb efflux and protein leakage from normal lenses exposed to unrelated antigen-antibody interactions.

Normal rabbit lenses exposed in vitro to heterologous antibody (Ab)--antigen (Ag) interactions lose control of the intracellular 86Rb; this membrane damage, which seems to be related to the quantitative ratio Ab/Ag, is relatively complement independent and is followed by a subsequent leakage of lenticular proteins. A possible implication of these findings in the development of complicated cataracts in uveitis (as 'permeability cataracts') and in the self-maintenance of recurrent uveal inflammation is shortly discussed.

Animals↗
PubMed1977

[Phospholipase A and lysophosphatidylcholine in the pathogenesis of "permeability cataracts" (author's transl)].

Phospholipase A and Lysophosphatidylcholine (LPC) have been shown harmful for normal lens permeability, inducing an efflux of intracellular macromolecules in organ cultures. These findings, superimposible to what has been shown in the lens for complement-dependent immune damage, along with the hypothesis that the cytotoxicity of complement is mediated by a phospholipase, are considered relevant as far as the pathogenesis of complicated cataracts in "immune" uveitis and the selfmaintenance of recurrent autoimmune (to lens proteins) anterior uveitis are concerned.

Animals↗
PubMed1976

Release of protein and cations from the lens in the presence of different antigen-antibody interactions.

Rabbit lenses exposed to unrelated Ag/Ab interactions and to heterologous anti-lens and anti-uveo-retinal antibodies show alterations of their permeability with loss of Rb+ followed by efflux of macromolecular intracellular constituents; these phenomena take place also without complement when the ratio of the unrelated Ag/ab is in Ag excess, while complement is strictly required for the action of anti-tissue antibodies. The possible role of these findings as regards the pathogenesis of complicated cataracts in uveitis and the self-maintenance of recurrent uveitis is briefly discussed.

Animals↗