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Biomedical subjects

A G Spinola

Publications and source records attributed to A G Spinola.

3 recordsLinked to original sources
PubMed1987

Renal dysfunction in Brazilian lead workers.

In this study, renal function of 52 workers of a primary lead smelter located in Northeast Brazil was compared to a reference group of 44 otherwise similar workers of a paper mill. Renal dysfunction, defined by a serum creatinine level greater than or equal to 1.5 mg/dl, was found in 17 (32.7%) workers at the lead smelter, the exposed group, but in only 1 (2.3%) individual from the reference group. Workers from the exposed group also showed significantly higher mean serum uric acid levels. Renal dysfunction of workers from the exposed group was statistically associated with duration of the employment at the smelter and with age, but not with the levels of lead and zinc protoporphyrin in blood and delta-aminolevulinic acid in urine. The two groups presented similar rates of arterial hypertension. However, arterial hypertension was much more strongly associated with renal dysfunction in the lead workers.

Adult↗
PubMed1983

Lead poisoning and hookworm infection as multiple factors in anaemia.

A retrospective study was carried out in a rural area of north-eastern Brazil, to search for interactions between biological and chemical agents present in the environment as causes of anaemia. A lead smelter situated in a hookworm endemic area provided the opportunity to look at the effect of this double exposure in relation to laboratory defined anaemia, by comparing the odds ratios in different subgroups of 109 "cases" and 107 "controls". The subgroup with both hookworm infection and chronic lead poisoning--measured by the concentration of delta-ALA excreted in urine--had an odds ratio of developing anaemia five times greater than individuals with neither. Although a synergistic effect could not be demonstrated, the additive effect of the two conditions placed this group in a higher risk category.

Anemia↗