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Biomedical subjects

A G de Vries

Publications and source records attributed to A G de Vries.

4 recordsLinked to original sources

Acute myocardial infarction while using the nicotine patch.

A 39-year-old man developed an acute myocardial infarction 20 days after starting treatment with nicotine patches. He had not smoked while using the patches. He recovered without complications. Coronary angiography did not reveal coronary stenoses. He had no history of myocardial infarction, hypertension, or diabetes mellitus. Although coincidence cannot be excluded, it is recommended that all patients should be strongly advised not to smoke while using the nicotine patch and to consult a physician if chest pain develops.

Administration, Cutaneous↗

Genetics of the interval from weaning to estrus in first-litter sows: distribution of data, direct response of selection, and heritability.

A selection experiment with a selection and a control line maintained for eight generations was set up to study efficacy of selection for a short interval from weaning to estrus after weaning the first litter and to estimate genetic variation in the Dutch Landrace population. Intervals were recorded without truncation (i.e., intervals up to 234 d were observed). A mating scheme with 10 mating groups was used to avoid inbreeding. Distribution of intervals from weaning to estrus was described by a mixture of a normal and an exponential distribution. Between lines, both underlying distributions were similar, but the contribution to the total distribution was different. From generation 4 onward, intervals were significantly shorter in the selection line than in the control line. Variances within lines, generations, and mating groups varied to a large extent. Response per unit selection differential was calculated for original data and three sets of transformed data, both with and without correction for unequal subclass numbers. Standardized responses were more precise and linear, when data were log-transformed, and when corrected for unequal subclass numbers. The assumed best estimate of the realized heritability was .17. The heritability in the foundation population was estimated at .36 +/- .05, using an animal model including all genetic relationships in the data. It was concluded that genetic selection decreases the average interval from weaning to estrus by reducing the number of sows with a record in the exponential part of the distribution.

Algorithms↗

Management of fixed subaortic stenosis: a retrospective study of 57 cases.

Although recommended by several investigators, the benefit of early surgery in patients with fixed subaortic stenosis has not been proved. Findings were reviewed of 57 patients with isolated fixed subaortic stenosis, including 27 surgically treated patients, with special emphasis on the occurrence of aortic regurgitation during a mean follow-up period of 6.7 years. The number of patients with aortic regurgitation increased preoperatively in the total group (23% at diagnosis to 54% after 3.7 years of follow-up). The prevalence of aortic regurgitation in the 27 surgically treated patients was higher (81%) than that in the nonsurgically treated group but remained unchanged after a mean postoperative period of 4.7 years. In all patients but one, aortic regurgitation remained of minor hemodynamic significance. One patient died during follow-up. After surgery, 15 patients (55%) showed a relapse; 11 redeveloped a subvalvular pressure gradient greater than 30 mm Hg and discrete subvalvular ridges (range 6 months to 24 years after surgery, mean 7 years). In those patients with fixed subaortic stenosis, follow-up did not reveal any benefit from early surgery. The unpredictable course and sometimes very severe progression of this disease make frequent and careful follow-up necessary.

Adolescent↗

The value of colour flow mapping in the diagnosis of a combined pseudoaneurysm and large true left ventricular aneurysm.

During ultrasound assessment of a large postinfarct apical left ventricular aneurysm, a related localized area of ventricular wall rupture was discovered by colour flow mapping. Other non-invasive and invasive techniques failed to demonstrate the pseudoaneurysm. The rare combination of a true and false left ventricular aneurysm in one patient and the diagnostic difficulties in this case uniquely illustrate the recent controversy concerning the definition and diagnosis of pseudoaneurysm. The clinical importance of colour flow mapping, as the most sensitive technique in detecting pseudoaneurysm, is emphasized.

Blood Flow Velocity↗