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Biomedical subjects

A Gómez Portilla

Publications and source records attributed to A Gómez Portilla.

At least 19 recordsLinked to original sources
PubMed2006

Management of peritoneal surface malignancy with cytoreductive surgery and perioperative intraperitoneal chemotherapy.

AIMS: A new treatment strategy combining maximal cytoreductive surgery for treatment of macroscopic disease and maximal perioperative intraperitoneal chemotherapy for residual microscopic disease, suggests that in a selected group of patients benefit is possible. The purpose of this study was to report our experience with this combined treatment and to identify the principal prognostic factors. METHODS: The study included 266 patients from 9 institutions operated on between July 1990 and July 2004. The median age was 55 years. RESULTS: The mortality rate was 7.8% and the morbidity rate 37.5%. The overall median survival was 13.7 months. Positive independent prognostic factors by multivariate analysis were gender, perioperative intraperitoneal chemotherapy and treatment by the second-look procedure. CONCLUSIONS: The therapeutic approach combining cytoreductive surgery with perioperative intraperitoneal chemotherapy achieved long-term survival in a selected group of patients with an acceptable morbidity and mortality.

Adult↗
PubMed2005

Peritoneal carcinomatosis of colorectal origin. Current treatment. Review and update.

Colorectal cancer is the most frequent tumor of the digestive tract. The high incidence of abdominal dissemination; the poor prognosis of these patients, with median survival consistently ranging from 5 to 9 months in all studies of peritoneal carcinomatosis from colorectal cancer; the failure of adjuvant systemic chemotherapy treatment with a maximal survival of 18 months despite the development of new cytostatic drugs, and new combinations of use, make it crucial to search for and develop new treatment strategies. We review the principles of Sugarbaker s treatment protocol, which involves the combination of maximum cytoreductive radical oncological surgery for the treatment of all macroscopically disseminated disease with maximum perioperative intraperitoneal intensification chemotherapy to treat residual microscopic disease. We present the results of several scientific papers, all of them phase II studies with more than 10 patients treated, published in the medical literature by the main groups working in this line of treatment, together with the only phase III study reported and published so far, and finally the results of a recently reported retrospective international multicenter study. With this new alternative therapeutic approach, overall mean survival is 40% at 36 months, and 20% at 5 years. Based on these results, this new therapeutic approach is proposed as the treatment of choice for these unfortunate patients.

Antineoplastic Agents↗
PubMed1990

[Measles-related appendicitis. A report of a new case].

We present a case of "Measles Appendicitis" treated recently in our unit. We point out the lack of bibliographic references on this pathology, despite its relatively high rate of incidence. The possible coexistence of appendicitis and measles; along with the possibility of a bacterial superinfection of the obliterated appendix due to submucous lymphoid hyperplasia, in our opinion, justifies an initial surgical approach in patients with measles who suffer from bouts of diagnostically uncertain pain in the lower right abdomen.

Acute Disease↗
PubMed1989

[Spiegel's hernia: apropos of 7 cases].

The authors present their experience with Spiegel's hernia and a series of seven cases, three of which debuted as intestinal occlusion. On four occasions the hernial content was appreciated, only one of which required resection. The diagnostic procedures most commonly used in this pathology are noted and it is concluded that sonography offers high resolution images and effectiveness in the differential diagnosis. In all the cases the hernia was located below the aponeurosis of the major oblique muscle. Herniorrhaphy was performed in every case, and there was no morbidity, mortality or recurrence of the hernia.

Abdominal Muscles↗
PubMed1989

[Extrahepatic biloma secondary to choledocholithiasis].

We present a case of extrahepatic biloma in a patient who was an emergency admission to the hospital and had a clinical pattern of obstructive jaundice secondary to choledocholithiasis. The diagnosis was made by echography and needle aspiration (PAAF). Due to the unfavorable evolution of the patient in the 48 hours after admission, she underwent surgery, which confirmed the diagnosis. Cholecystectomy was performed, with removal of the choledochal gallstone and side-to-side choledochoduodenostomy, and the postoperative evolution was satisfactory. We review the pathophysiologic characteristics of this entity and its etiology, symptomatology, diagnosis and treatment.

Aged↗