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Biomedical subjects

A Gürbüz

Publications and source records attributed to A Gürbüz.

16 recordsLinked to original sources
PubMed2006

Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model.

OBJECTIVE: In ischemia-reperfusion, Iloprost decreases neutrophil activation and aggregation besides inhibition of oxygen-free radical production. Pentoxifylline (Ptx) attenuates reperfusion-associated membrane injury and tissue edema, suppresses leukocyte adhesion and improves hindlimb blood flow during the reperfusion period. The primary hypothesis in this study was that Iloprost could present better protection than pentoxyfillin on renal ischemia-reperfusion in rabbit model. MATERIALS AND METHODS: Forty rabbits were grouped into four. Iloprost was continuously infused starting half an hour before the reperfusion after 2 hours ischemia and during the 4 hours reperfusion period in Group 1 whereas the Group 2 was treated with pentoxyfillin. Group 3 was the control group which didn't receive any medication. Forth group was sham group. Renal tissues were histologically and biochemically evaluated. RESULTS: The histologic scores were obtained according to presence of tubuler necrosis and atrophy, regenerative atypia, hydropic degeneration (Group 1 vs Group 3; p<0.001, Group 2 vs Group 3; p = 0.001, Group 1 vs Group 2; p = 0.331). Malondialdehyde levels of the medicated groups were 109 +/- 11 nmol/gr tissue in Group 1, 119 +/- 15 nmol / gr tissue in Group 2 and 132 +/- 14 nmol / gr tissue in Group 3 (Group 1 vs Group 2; p = 0.130, Group 1 vs Group 3, p = 0.002, Group 2 vs Group 3; p = 0.045). Malondialdehyde levels and histologic scores of all of the groups were significantly different from the sham group. CONCLUSION: Iloprost and pentoxyfillin reduced renal ischemia-reperfusion injury in rabbit model. There was not a significant difference between these two medications.

Animals↗
PubMed2006

Management of a case of primary vaginal cancer with irreducible massive uterine prolapse--a case report.

Primary cancer of the vagina constitutes 1-2% of all malignant genital tract tumors in women. As one of the most complicated therapeutic problems in gynecological oncology, this disease had been deemed to be untreatable until the end of 1930s. Presently, as a result of technological improvements in radiotherapy and radical surgery, more favorable prognoses are known to be achieved even in advanced cases. In the present case, a woman with vaginal cancer and Stage IV massive uterovaginal prolapsus, which could not be repositioned under general anesthesia, was repositioned by surgical intervention prior to radiotherapy to avoid any potential vesicovaginal fistula formation. The cervix was bilaterally suspended to the pectineal ligaments by polypropylene mesh.

Aged↗
PubMed2005

A novel approach: ascending venous arterialization for atherosclerosis obliterans.

OBJECTIVE: Lower limb arterial occlusion with no patent distal artery suitable for revascularisation is a common problem. The aim of this study was to assess the role of revascularisation to distal veins (ascending venous arterialization) in patients not reconstructable by conventional bypass. METHOD: Ascending venous arterialization is a distal arteriovenous fistula. Reversed great saphenous vein grafts, from above the knee, were anastomosed to the common femoral artery, superficial femoral artery or popliteal artery and distally to the saphenous vein at the level of medial malleolus. No intervention was done to destroy the venous valves. The great saphenous vein was ligated below the knee. In this way, oxygenated blood could reach to dorsal venous arch and the tissues below the knee in an ascending fashion through the great saphenous vein, which was not removed. RESULTS: All of the patients recovered immediately after the operation. The lesions on the feet and on the toes of the patients improved in a short time. Intermittent claudication of the patients disappeared. Strong pulses were detected on the dorsal venous arch with manual Doppler in 3 weeks. The below knee tissues were perfused with the applied technique. CONCLUSION: Ascending venous arterialization can be applied for limb salvage to the patients who do not have a suitable arterial bed to revascularize with conventional techniques.

Adult↗
PubMed2004

Evaluation of flow hemodynamics by color-Doppler following two different brachial arterial repair techniques.

OBJECTIVES: We compared the clinical and hemodynamic results following surgical repair of traumatic brachial artery injury using two different techniques micro- and macrovascular repair. MATERIALS AND METHODS: This was a retrospective study of 27 patients who had sustained penetrating, clean cut injuries of the brachial artery. Macrovascular techniques and a saphenous vein graft was used in 13 patients, while 14 patients were treated by primary microsurgical technique. Postoperatively, patients were followed for a mean of 26 months. All patients had color Doppler examination of the brachial artery, digital artery pressures and transcutaneous oxygen saturation determined. RESULTS: Clinical results based on distal pulses, Allens test and digital pressures were similar in the two groups. Color Doppler showed 8/13 anastomotic stenoses in macrovascular vein grafted repairs and 2/14 in microvascular repairs (p<0.05). The ratio of flow velocity proximal compared distal to the injury was significantly decreased in patients who had macrovascular repairs. CONCLUSION: Using ratio between proximal and distal site of anastomosis maximal peak systolic velocity as a objective color Doppler parameter, we were able to demonstrate differences in the hemodynamic status following macrovascular repair with vein grafts and microvascular primary repair. The results emphasize the importance of using a standard repair technique for similar injuries rather than the preference of the surgeon.

Adolescent↗
PubMed2001

A critical observation about the pathogenesis of abdominoscrotal hydrocele.

Abdominoscrotal hydrocele is a very rare anomaly. Although various theories about this condition have been proposed, controversy still continues on the etiology of this lesion. The authors present two consecutive cases of abdominoscrotal hydrocele in infancy. On their first examination, these patients only had inguinoscrotal hydroceles. After a 2-month period of observation, these inguinoscrotal hydroceles developed into abdominoscrotal hydroceles. These findings also were confirmed by ultrasonography. The authors question the currently proposed theories of abdominoscrotal hydrocele development.

Abdomen↗
PubMed2001

Mechanical versus biological valve prosthesis in the mitral position: a 10-year follow up of St. Jude Medical and Biocor valves.

BACKGROUND AND AIM OF THE STUDY: During the past 30 years, the development of mechanical and biological valves has led to major improvements in patient survival. Here, we present long-term results obtained with both types of prosthesis. METHODS: At our institution, between 1985 and 1989, 158 patients received a Biocor porcine bioprosthesis, and 100 patients a St. Jude Medical (SJM) mechanical valve. Preoperatively, mean age, male:female ratio, NYHA functional class and pathology of mitral valve disease were similar in both groups. RESULTS: The 30-day mortality was 4.4% in the Biocor group and 4% in the SJM group, the major cause being congestive heart failure. Late mortality was 17.9% and 15.6% respectively in the two groups, but valve-related mortality was very low in both (1.3% versus 4.2%). Ten-year survival was similar in each group (77.8+/-3.4% versus 81.0+/-3.9%; p = 0.538). Ten-year freedom from anticoagulant-related hemorrhage was higher with Biocor prostheses (99.3+/-0.7% versus 90.9+/-3.1%; p = 0.007). Valve thrombosis was seen only in the SJM group, and structural valve degeneration (SVD) only in the Biocor group. Ten-year freedom from reoperation was lower in the Biocor group (84.9+/-3.2% versus 92.2+/-2.8%; p = 0.206). The significant causes of reoperation were SVD in the Biocor group and valve thrombosis in the SJM group. Freedom from prosthetic valve endocarditis was similar in both groups (96.3+/-1.6% versus 95.5+/-2.2%). CONCLUSION: As no difference was seen in survival and reoperation rates between patients receiving either bioprostheses or mechanical valves, the valve used will depend on the surgeon's choice and the type of patient, notably elderly patients who are intolerant of anticoagulation, and young women wishing to have children.

Adolescent↗
PubMed2000

Combined transdiaphragmatic MIDCAB with right gastroepiploic artery and abdominal aortic aneurysm repair.

Combined surgical repair for large abdominal aortic aneurysm and severe symptomatic coronary artery disease is a safe and effective procedure. Simultaneous operation for minimally invasive direct coronary artery bypass and abdominal aortic aneurysm repair were performed on a 75-yr-old man. First, we harvested the right gastroepiploic artery and passed it through the diaphragma for the right coronary artery revascularization on the beating heart. We then repaired the large abdominal aortic aneurysm (8 cm in diameter) using a Dacron tubular Y-graft. Using the arterial graft and off-pump technique reduces operation time and prevents complications of cardiopulmonary bypass in elderly patients with large abdominal aortic aneurysm, while the combined approach shortens hospital stay and cost.

Aged↗
PubMed1999

Three ventriculoplasty techniques applied to three left-ventricular pseudoaneurysms in the same patient.

A 59-year-old male patient underwent surgery for triple-vessel coronary artery disease and left-ventricular aneurysm in 1994. Four months after coronary artery bypass grafting and classical left-ventricular aneurysmectomy (with Teflon felt strips), a left-ventricular pseudoaneurysm developed due to infection, and this was treated surgically with an autologous glutaraldehyde-treated pericardium patch over which an omental pedicle graft was placed. Two months later, under emergent conditions, re-repair was performed with a diaphragmatic pericardial pedicle graft due to pseudoaneurysm reformation and rupture. A 3rd repair was required in a 3rd episode 8 months later. Sternocostal resection enabled implantation of the left pectoralis major muscle into the ventricular defect. Six months after the last surgical intervention, the patient died of cerebral malignancy. Pseudoaneurysm reformation, however, had not been observed. To our knowledge, our case is the 1st reported in the literature in which there have been 3 or more different operative techniques applied to 3 or more distinct episodes of pseudoaneurysm formation secondary to post-aneurysmectomy infection. We propose that pectoral muscle flaps be strongly considered as a material for re-repair of left-ventricular aneurysms.

Aneurysm, False↗
PubMed1999

Surgical repair in ruptured congenital sinus of Valsalva aneurysms: a 13-year experience.

BACKGROUND AND AIM OF THE STUDY: Rupture of congenital sinus of Valsalva aneurysm is a rare cardiac malformation that usually causes reduced cardiac performance. METHODS: Twenty patients (mean age 28.3 +/- 10.7 years; range: 14 to 55 years) with rupture of congenital sinus of Valsalva aneurysm were operated on at our institution between January 1985 and March 1999. The origin of the ruptured aneurysms was the right coronary sinus in 18 patients (90%) and the non-coronary sinus in two (10%). No ruptures were observed originating from the left coronary sinus. The aneurysms ruptured into the right ventricle in 14 patients (70%), into the right atrium in five (25%), and into the left ventricle in one patient (5%). Subarterial ventricular septal defect (VSD) was the most common associated defect (30%), and aortic insufficiency the second (20%). No correlation was found between subarterial VSDs and aortic insufficiency (p > 0.05). To achieve repair, the aorta and cavity into which the aneurysm had ruptured were opened. The aneurysmal sac was excised and the defect closed with a patch in 18 patients, and without patch in two. RESULTS: One patient died in hospital (mortality rate 5%); no late mortality was observed. Surviving patients were followed up for 4.4 +/- 3.3 years (range: 1 to 13 years). The actuarial survival rate was 95% at 12.35 years. Recurrence of fistula was observed in one patient (5%) in whom the ruptured aneurysm had been closed by primary suture without the use of a patch. At 12.35 years, the actuarial freedom from recurrence of fistula was 94.74% for all survivors, and 100% for patients with patch closure. No late complications have been observed. CONCLUSIONS: Following diagnosis of ruptured sinus of Valsalva aneurysm, surgical repair is the treatment of choice. Surgery performed as rapidly as possible after diagnosis in general leads to an excellent outcome.

Adult↗
PubMed1990

[Clinical comparison of different types of obturators constructed after maxillary resections].

This investigation was carried on eight patients who had undergone partial maxillary resection for the eradication of tumors. Two types of obturators, one being hollow-bulb and the other buccal flange were constructed for each patient, using different impression techniques. When these were compared clinically, it was concluded that buccal flange obturators which were constructed without closed hollow sections were superior to the hollow-bulb obturators with closed nasal sections extending as far as possible into the anterior and lateral aspects of the defect, in comfort, function, speech and stabilization.

Humans↗
PubMed1990

[The application of an overdenture with a modified Dolder bar joint].

In this article, a modified Dolder bar attachment application is presented in two cases. The egg-shaped bars are casted in chromium-cobalt metal alloy and the retention loops are made of clasp wire in "omega" shape. The bar attachment has some advantages like being easy to fabricate and having lower cost. The laboratory made modified Dolder bar attachment we used with overdentures provided additional retention for the dentures, minimized the horizontal and vertical movements of the dentures and also strengthened the abutment teeth by splinting. As a conclusion we have tried to show that this attachment can be an alternative to use with overdentures.

Denture Precision Attachment↗
PubMed1990

[Overlay dentures].

Overlay dentures which are accepted as superposition appliances have been presented by three cases in this article. These kind of dentures are dedicated as prosthodontic restorations which are applied to extend maxillary arch horizontally in the cases of maxillary collapse. These restorations also increase the vertical dimension which has been lost and so help to improve the facial contour as well as esthetics of the individual-these dentures classified as removable partial or complete overlay dentures are generally applied in the cases of bilateral or unilateral maxillary collapse which have been caused by trauma or tumor resection.

Denture, Overlay↗
PubMed1989

[Electromyographic evaluation of different types of obturators constructed after maxillary resections].

Our investigation included 6 patients who had undergone extensive surgery for eradication of neoplasms of the maxillae. Their surgical defects were similar and they had natural teeth on the unresected side. Two types of obturators were constructed for each patient, one being hollow-bulb and the other buccal flange. The hollow-bulb obturators had closed nasal sections extending as far superiorly as possible into the anterior and lateral aspects of the defect. Buccal flange obturators were constructed without closed hollow sections. Our study was designed to compare these obturators electromyographically. When the results were evaluated statistically, it was concluded that buccal flange obturators were superior to hollow-bulb obturators in stabilization and function.

Electromyography↗
PubMed1989

[Speech intelligibility in various types of obturators constructed after maxillary resections].

Six patients who had undergone partial maxillary resection for the removal of oral neoplasms were studied. For each patient two types of obturators were made one being buccal flange and the other hollow-bulb. Speech evaluations were made under three conditions: 1- with the hollow-bulb 2- with the buccal flange and 3- with no obturator. Speech evaluations were made both audiovisually and from tape recordings. In both audiovisual and tape recorded speech evaluations, the buccal flange obturator produced speech which was significantly superior to speech with hollow-bulb obturator.

Humans↗
PubMedDate not supplied

Pentoxifylline in male-factor infertility: its therapeutic efficacy after oral administration.

OBJECTIVE: To determine whether the oral use of pentoxifylline improves the fertilization ability, concentration and motility of spermatozoa of poor fertilizer male subject. DESIGN: Analysis of the spermiogram parameters before and after oral pentoxifylline administration. SETTING: Zeynep Kamil Women and Children's Hospital, Department of Infertility. PATIENTS: Fourteen healthy, untreated male partners of couples who applied to our infertility department and were found to have poor semen parameters. MAIN OUTCOME MEASURES: Data of the semen analyses and fertilization rates are compared before and after treatment. RESULTS: Before the treatment, the average percentage sperm motility and density were 30.1 +/- 8 (%) and 14.8 +/- 3.2 (10(6)/ml), respectively. The same parameters were found to be 37.8 +/- 13 (%) and 19.5 +/- 10 (10(6)/ml), respectively, following the treatment. Not significant, p = 0.08 and p = 0.116, respectively). CONCLUSION: None of the semen parameters evaluated were improved by oral administration of pentoxifylline. Therefore pentoxifylline does not increase percentage motility and density of spermatozoa or the fertilization rates.

Adult↗