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Biomedical subjects

A Galassi

Publications and source records attributed to A Galassi.

At least 55 records · Page 3Linked to original sources
PubMed1982

Multicenter evaluation of mepindolol and of mepindolol plus hydrochlorothiazide in essential hypertension.

The effect on systolic (SAP) and diastolic (DAP) arterial blood pressure of 5 mg mepindolol daily vs 12.5 mg hydrochlorothiazide daily vs 5 mg mepindolol plus 12.5 mg hydrochlorothiazide daily was evaluated in this multicenter study. After a 2-week washout period with placebo, 138 patients with mild to moderate essential hypertension (WHO Class I and II), homogeneous for age and blood pressure values, were randomly allocated to one of the three treatment groups. Arterial blood pressure and heart rate were obtained at the beginning and at the end of the washout placebo period, and after 2, 4, and 6 weeks of active treatment. At the beginning and at the end of the study, all patients underwent a thorough clinical and laboratory evaluation, including blood chemistry, electrocardiogram, and chest roentgenogram. A trend toward normalization of blood pressure was defined as a lowering of DAP to 90 mmHg or at least a 10-mmHg decrease from the control value. Statistical analysis was performed on all the data. After 6 weeks of treatment, SAP and DAP values were significantly reduced in 67% of the patients in all groups. In 71% of patients on mepindolol plus hydrochlorothiazide a particularly more marked decrease in DAP was observed. Mepindolol was well tolerated: side effects were generally mild and inconsequential. The results show that mepindolol, given as a single oral dose of 5 mg, is an effective agent in the treatment of mild to moderate essential hypertension. Because of its efficacy, the advantage of single daily administration, and lack of important side effects, it can increase compliance to therapy. Moreover the association of mepindolol plus hydrochlorothiazide appears to be safe and effective.

Blood Pressure↗
PubMed1981

[Digitalization of the arrhythmic heart patient].

Digitalis combines a longstanding tradition with constant up-to-dateness. Kinetic maintenance therapy is very often required for heart patients with arrhythmia as one of their most striking clinical manifestations. The well-known questions of paroxystic tachycardia, flutter and atrial fibrillation are examined, and attention is concentrated on ventricular extrasystole, sinoatrial node disease, and Wolff-Parkinson-White syndrome. It is clear that combinations with recently introduced antiarrhythmic drugs, and administration of diuretics and electrolytes, and the employment of electrical stimulation have facilitated the long-term treatment of the chronic arrhythmic heart patient and brought about the better utilisation of digitalic substances. Their arrhythmogenic potential, however, cannot be overlooked.

Arrhythmias, Cardiac↗
PubMed1981

Double blind controlled trial with oxmetidine and cimetidine in the short-term treatment of duodenal ulcer.

Clinical efficacy and safety of oxmetidine (400 mg b.i.d.), a new potent specific H2-receptor antagonist, and cimetidine (1 g/day) were compared in a double-blind randomized trial of 4 weeks duration that involved 39 outpatients with endoscopically proven active duodenal ulcer. The disappearance of the ulcer crater leading to complete reepithelization of the bulbs or to the presence of erosions occurred in 17 out of 19 (89.6%) patients treated with oxmetidine, and in 13 out of 20 (65.0%) patients treated with cimetidine (n.s.). Ulcer symptoms and antacid consumption were not different in two groups. No side effects or significant haematological or biochemical abnormalities were found. Both drugs failed to evoke significant changes in the basal levels of prolactin (PRL) and gonadotropins. The higher, though not significant, percentage of healing obtained with oxmetidine had no clinical relevance and needs to be demonstrated in a larger number of patients.

Adult↗
PubMed1978

[Cardiac pacing in Sicily (author's transl)].

We report the experience in Sicily, where more than 3000 pacemakers have been implanted in different Schools of Medicine and Hospitals (Agrigento, Catania, Messina, Palermo and Ragusa). Our personal experience (Cardiology Division--Catania) is 846 cases up to June 1977. We would like to stress that today the sick sinus syndrome and other pathological conditions not due to complete AV block are of increasing incidence as an indication to definitive electrostimulation. In addition, the average age of patients is getting lower, and more PM-demand and lithium powered PM are implanted. The most used implant technique has been through the cephalic vein. Today it is possible to have more distant controls mainly because of the oscilloscopic evaluation technique. Mortality during surgery and immediately post-surgery is very low, and the bioelectric complications are very rare. In conclusion, we would suggest: 1) a strict cooperation with a Cardio-surgery Division; 2) the utilization of more sophisticated techniques to make controls less frequent and more rapid and easy (e.g. telephone controls); 3) a more modern and correct law on this issue and a better information of the public, involving educational, social and medical structures so that the patient with a pacemaker can live in his family with a recovery for work and society.

Adult↗
PubMed1977

[Rehabilitation in various types of heart diseases].

The occasions on which reevaluation, re-establishment, readaptation, and rehabilitation in the true sense should be used are discussed, and the concept of both psychological and physical rehabilitation as an indivisible whole is underscored. It is also made clear that rehabilitation must not be limited to the heart patient himself, but be seen as the reintegration of the subject (and not the object) of rehabilitation in his family, social, occupational and recreational environment. Rehabilitation begins during hospitilisation and short- or long-term programmes are prepared. Full rehabilitation requires readjustment of the patient's surroundings and the removal of preconceptions and misunderstandings that may often make communication dramatically impossible.

Adolescent↗
PubMed1977

[The medico-social problem of rheumatic valve disease in Sicily].

The incidence of rheumatism and rheumatic valvulopathy in Sicily is assessed and the sites most commonly involved in the first and second attacks described. The medical aspects of te question are examined from several points of view: prophylaxis of sites, medical treatment personal and ambient hygiene, gradual defectiveness of the pump, associated diseases, etc. The concept of invalidity is viewed in terms of direct and associated anatomical damage and frank and potential invalidity (absolute or relative), the weight or assistance attributable to the family and the incidence of the local social environment in the question of finding work, etc. The basic criteria for surgery are noted. Care must be taken to preserve the few remaining structures. Mortality is still high and the incidence of heart disease is higher among rheumatic Sicilian children. Not enough is known about overcrowding, the schools attended by the poor, and the higher incidence in low-income classes. Failure to affront some of these features, determined as much by action (or its postponement) by government as by income, results in meaningless medicine, divorced from social reform and true the scientific spirit, a cover for special interests and a demonstration of profit factors wherein the commercialising relationship is increasingly evident.

Aortic Valve↗
PubMed1977

[Permanent endocardiac electrostimulation. Considerations on 511 implantations and reimplantations in 7 years of practice].

Permanent pacemakers were implanted and reimplanted in a total of 511 patients (mostly men) during a period of about 7 yr. Mean age was 67.9 yr. The cephalic route was used in nearly every case, with subclavicular implantation of the generator. Mean hospital stay was 7.6 days. Ventricular inhibition pacemakers were used in over 84% and fixed-frequency models in 7%. Mean pacemaker life was 24.1 months, with longer periods in the last months of the period of observation. The evaluation of battery run-down and recent and long-term complications is discussed, together with a particular type of decubitus of electrolytic origin. Hospital mortality was 2%. Survival was 91% at 1 yr and 54% at 6 yr. Emphasis is placed on the fact that subjects continue to be heart patients. Their well-being depends on psychological and general medical care, together with help from their, families and society, quite apart from cardiological attention.

Adult↗