Biomedical subjects

A García Alonso

Publications and source records attributed to A García Alonso.

15 recordsLinked to original sources

PubMed1992

[Correlation of creatine phosphokinase blood level with prenatal fetal heart rate as a prognostic factor in tissue hypoxia].

The presence of a high serum activity of the creatinine phosphokinase enzyme (CPK) could be the result of an hypoxic tissue event. The existence of an ominous fetal heart rate tracing is a reliable method which indicates the presence of an hypoxic state in variable degrees. Thirty-five pregnancies between 34 and 41 weeks of gestation were prospectively studied to correlate both, CPK activity and cardiotocography, with perinatal morbidity and mortality. All the patients had antepartum fetal heart rate testing and pregnancy was terminated by cesarean section within seven days to the last fetal heart tracing. As soon as the baby was born, we took an umbilical cord sample to measure CPK activity and a second sample was also taken at 36 hours of life. All the neonates had pediatric, neurologic, electrocardiographic and sonographic evaluation within their 48 hours of extrauterine life. Two groups were created: Group A included 14 neonates with normal cardiotocographic tracings (control group) and Group B had 21 infants with abnormal tracings (study group). We found an elevated serum CPK activity with statistic significance in the next three conditions: a) In the sample at 36 hours of life when compared to the cord sample in the control group, p less than 0.001; b) In the neonatal sample at 36 hours of age when compared to the cord sample in the study group, p less than 0.001; c) In the neonates of the study group compared to the neonates of the control group at 36 hours of extrauterine life, p less than 0.05.(ABSTRACT TRUNCATED AT 250 WORDS)

Cell Hypoxia↗

PubMed1990

[Biophysical profile in prolonged pregnancy. Another alternative of fetal surveillance].

The value of the biophysical profile scoring to predict occur-rate perinatal outcome in prolonged pregnancy, was assessed. 60 patients with the diagnosis of prolonged pregnancy were included in this prospective clinical trial. A fetal biophysical profile score, described by Manning and modified by Johnson, was recorded in all these patients. There were 40 cases (66%) with normal profile scoring 3 of which had a feature considered as perinatal morbidity (specificity 94.8%). In contrast, from 20 cases with abnormal profile scores, 18 (90%) had abnormal perinatal findings (sensitivity 85.7%). The false positive and negative rates were low, 10 and 7.5% respectively, and the global predictive value of this test was 90%. In our study the amniotic fluid volume was the profile variable most able to identify a compromised fetus and the second with the highest specificity. Although we had a high cesarean section rate, (71%), we suggest that with normal profile scores (greater than or equal to 8) and normal amniotic fluid volume, the fetal biophysical profile may be an accurate test in the evaluation of the fetal condition in this obstetric complication.

Female↗

PubMed1990

[Biophysical profile in prolonged pregnancy. Another alternative to fetal monitoring].

The value of the biophysical profile scoring to predict accurate perinatal outcome in prolonged pregnancy, was assessed. 60 patients with the diagnosis of prolonged pregnancy were included in this prospective clinical trial. A fetal biophysical profile score, described by Manning and modified by Johnson, was recorded in all these patients. There were 40 cases (66%) with normal profile scoring 3 of which had a feature considered as perinatal morbidity (specificity 94.8%). In contrast, from 20 cases with abnormal profile scores, 18 (90%) had abnormal perinatal findings (sensitivity 85.7%). The false positive and negative rates were low, 10 and 7.5% respectively, and the global predictive value of this test was 90%. In our study the amniotic fluid volume was the profile variable most able to identify a compromised fetus and the second with the highest specificity. Although we had a high cesarean section rate, (71%), we suggest that with normal profile scores (greater than or equal to 8) and normal amniotic fluid volume, the fetal biophysical profile may be an accurate test in the evaluation of the fetal condition in this obstetric complication.

Female↗

PubMed1989

[Fetal growth in prolonged pregnancy].

Posterm pregnancy still is a topic full of controversies in many aspects, such as diagnosis, perinatal risk and management. This paper suggests that a great number of fetuses from prolonged pregnancies, still grow after term, secondary to a persistent and adequate placental function; it's demonstrated, by comparing the distribution of newborn weights between term and posterm pregnancies. In the posterm group a significant increase in the incidence of hypertrophic newborns, is found. Dismature newborns, products of the placentary insufficiency in posterm pregnancy, although the point of interest of obstetricians, pediatricians and perinatologists because of its high rates of morbimortality, constitute a minority in comparison with fetus of posterm pregnancies with high newborn weights. It is possible that fetal hypertrophy by it self may be another cause of morbimortality in posterm pregnancies (because of dystocias, prolonged labor, altered fetopelvic relations, increased rates of cesarean sections, and others) that must be determined in future longterm, prospective analysis.

Birth Weight↗

PubMed1989

[Sinusoid pattern. Perinatal consequences].

This is a review of 7,203 antepartum fetal heart rate recordings. It was found that the sinusoidal pattern is rare for fetal heart rate, which is seen more frequently in patients with severe Rh isoimmunization, that is easily identified, and it may lead to interruption; in its incomplete form will allow to evaluate the cases totally, as it'bit a severe fetal condition.

Cardiotocography↗

PubMed1988