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Biomedical subjects

A García Pérez

Publications and source records attributed to A García Pérez.

At least 19 recordsLinked to original sources
PubMed2005

[Treatment of Tourette syndrome and its comorbidity: experience with 17 cases].

INTRODUCTION: Clinical characteristics and comorbid disorders of Tourette syndrome (TS) are reviewed along with a presentation of our experience with 17 cases. MATERIAL AND METHODS: We carried out a retrospective study of pediatric patients with TS admitted from 1998 to 2004 in Fundación Hospital Alcorcón. RESULTS: Seventeen patients were obtained, 16 of whom were men and there was only 1 woman. Present age ranged from 7 to 17 years old. Most frequent comorbid disorders were attention deficit disorder (ADD) in 9 patients, (53%), obsessive-compulsive disorder in 8 (48%) and anxiety in 7 (41%). Learning disorders were found in 7 patients (41%), 5 of whom have concurrent ADD and 1 severe obsessive compulsive disorder. Psychopharmacological treatment was withdrew in the 2 cases treated with halloperidol due to the presence of severe extrapyramidal symptoms (EPS) and in 3 of the 7 cases treated with pimozide (one of them was withdrawn due to EPS). No EPS was found with atypical neuroleptics, but sedation and weight gain was common. Methylphenidate was administered to 7 patients without an increase in tics. CONCLUSIONS: In our sample the most common comorbid disorders were ADD, obsessive-compulsive disorders, anxiety and learning disorders. Atypical neuroleptics were better tolerated than classic ones, although the incidence of side effects is elevated. Methylphenidate was not associated with tic worsening.

Adolescent↗
PubMed2001

["De morbis qui in superficie corporis videntur" (St. Isidore of Seville, 621 A.D.) the first dermatology text in Europe].

San Isidoro of Sevilla (562-636) was a learned Spaniard of the early Middle Ages. His principal work, the Etymologies, is an encyclopedic treatise which analyzes the origin and meaning of about 5,500 terms corresponding to the different knowledge of his era. Liber IV of the Etymologies is dedicated to Medicine, and one of his chapters, titled De morbis qui in superficie corporis videntur (The diseases that are seen on the skin surface), studies 32 terms corresponding to skin diseases, so that this chapter represents the first text dedicated specifically to Dermatology in Europe. At the same time, according to the general plan of the work that includes each term with its origin and its definition, Liber IV (De Medicina) would be the oldest medical terminology dictionary known.

Dermatology↗
PubMed2001

[Torticollis after unnoticed pharyngeal perforation: suspected retropharyngeal abscess].

Pharyngeal perforations due to foreign bodies are severe when retropharyngeal space infection develops into an abscess. Although the common clinical presentation is sore throat and fever, when the perforation remains occult, torticollis can be a significant symptom. Palatopharyngeal lesions, caused by rigid objects' impactation through the mouth, are common in childhood. Most are not important, but all have the potential hazard of pharyngeal perforation with development of a retropharyngeal abscess. It must be suspected specially when air is shown in the retropharyngeal space on a lateral radiography of the neck, which should always be done. We report a 9-years old boy who had cervical stiffness and torticollis and elevation of the right shoulder, without previous known trauma. Air was shown in the retropharyngeal space on a lateral radiography of the neck in relation to a possible pharyngeal perforation which was later confirmed by a CT scan. We review the literature about diagnosis and treatment of retropharyngeal abscess in childhood.

Child↗
PubMed2001

[Precocious puberty and pituitary incidentaloma].

The case of an 9-year-old girl with precocious puberty and a non-functioning pituitary adenoma is described. A review of the literature on the incidence, evolution and therapeutic options of pituitary incidentalomas in children and adults is performed.

Adenoma↗
PubMed2000

[Cutaneous tuberculosis yesterday and today].

Cutaneous tuberculosis were very frequent in Europe until the middle of the 20th. Century in which their incidence decreased drastically as a consequence of the specific treatments. On the other hand, the M. bovis caused infections which were previously very common have also been disappearing due to control of milk and the livestock produced for eating purposes. Cutaneous tuberculosis have classically been divided into two groups: typical tuberculosis, with follicular structure and demonstrated bacillus by culture or inoculation and atypical tuberculosis (tuberculids), in which there are no follicular structure and the bacillus is not isolated. Its relationship with tuberculosis is principally based on the personal and/or familial background and on the strong positivity of the Mantoux reaction. The concept of tuberculide has always been under debate. Above all in the second half of the 20th. Century, most of the authors were skeptical in regards to its tuberculous etiology. However, since the 1990's, determinations of bacillary DNA in the lesions by the PCR technique has made it possible to demonstrate the M. tuberculosis in them. At present, due to the probably re-emergence of tuberculosis in general as consequence of the immunodeficiency (AIDS), of the M. tuberculosis strains resistant to treatment, and of the cases imported by immigration, some increase in the incidence of cutaneous tuberculosis can be predicted in the future, although it need be feared that this will reach the amounts of other periods. On the other hand, immunodeficiences have made the anergic forms, such as tuberculosis cutis miliaris diseminata or tuberculous gumma, which were previously rare, less rare al present.

Communicable Diseases, Emerging↗
PubMed1999

[An epidemiological study of acute intoxications and provision of medical-cabinet antidotes].

OBJECTIVES: The aims of this work is to know first, the characteristics of the cases of acute intoxication seen in the emergency room of he "Hospital Clínico de Salamanca", Spain; and second, the existence of first-aid antidote kits, their location within the hospital, and their supplies in relation of the level of assistance being provided in hospitals in the region of "Castilla-León". METHODS: All cases of acute intoxication attended in the Emergency Room in he "Hospital Clínico de Salamanca" during one year (from June 1993 through May 1994) were studied prospectively. A descriptive analysis of several variables was performed including age, sex, monthly distribution, causes, toxic substances involved, route of exposure, clinical manifestations, treatment, department in witch patients were admitted and clinical evolution. Additionally, a questionnaire was sent to physicians in charge of emergency services of hospital in "Castilla-León" regarding the existence, location an equipment of first-aid antidote units. RESULTS: A total of 425 cases of acute intoxication were attended, representing 0.69% of all cases seen in the emergency room, during the mentioned period. The age range with the highest incidence was 20-30 years, representing 28.94% of the cases of acute intoxication. 51.3% of cases corresponded to male individuals, although in the 20-30 year range 63.11% were females. February was the month with the highest incidence. With regard to etiology, accidental exposure was the most common, representing 60.47% of cases, while among females 49.28% of cases of intoxication were self inflicted. The toxic substances most frequently involved were alcoholic drinks (23%) and benzodiazepines (17.16%). Recreation and opiate drugs represented 16.23% of the cases. The route of exposure was oral ingestion in 81% of cases and the most common clinical manifestation were of neurologic type which were present in 48% of patients attended. 25% of patients were admitted, representing 0.80% of admissions from the Emergency Room, with the intensive care unit and the Department of Psychiatry (32% of cases in each one) being the areas in which the highest number of patients were hospitalized. The number of patients that died was 2, which represents 0.47% of intoxicated patients attended. In 40% of hospital of the region there is a specific location within the Emergency Room for the first aid antidote drug kit. There is a good correlation between the levels of assistance of hospitals of Castilla-León and the supplies of the first aid antidote kit in the Emergency Room as well as in the Pharmacy Unit.

Acute Disease↗
PubMed1999

[Epidermolysis bullosa].

The epidermolysis bullosa are a group of genodermatoses in which there is congenital fragility of the skin which produce blisters with the least of traumas. The group includes up to thirty clinical-genetical entities. They are classified according to the level where the blister is found into simplex or epidermolytic (intraepitelial blister), junctional (blister in the dermoepidermal junction) and dystrophic or dermolytic (subepidermal blister) epidermolysis bullosa. The symptoms, classic or Mendelian genetics and the recent findings in the most frequent forms of each one of these groups are reviewed. In most of them, the gene that produces the mutations and the chromosome in which its locus is found are known. In the simplex forms, the disorders lies in the genes that codify the different keratins. In the junctional ones, mutations are found in the laminin genes that act in the development of the anchoring filaments or in those of the other components of the basement membrane. In the dystrophic ones, which are the most serious, the mutations affect the collagen VII gene that codify the development of the anchoring fibrils. There is no treatment for any of the forms of epidermolysis bullosa. It is possible that the future advances in genetic engineering can contribute to their prophylaxis.

Basement Membrane↗