Exercise testing three weeks after myocardial infarction.
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Biomedical subjects
A Gassmann
Publications and source records attributed to A Gassmann.
[Cell division, cytolysis and regeneration after cyclophosphamide].
Cytokinetic effects of 5 or 20 mg cyclophosphamide/kg body weight on thoracic duct lymph and blood cells of calves were analyzed. The larger dose caused a temporary cessation of lymphoid cell division, reduced the output of nondividing small lymphoid cells and impaired proliferation of neutrophil precursors. Feedback mechanisms acting on GO/G1 cells controlled the proliferation of lymphoid cells.
Animals↗
Effects of single cyclophosphamide doses on the kinetics of thoracic duct lymph and blood leukocytes in calves.
After 5 or 20 mg cyclophosphamide per kg body weight, given once i.v., the output in thoracic duct lymph of small and large lymphoid cells, cells incorporating [3H]lymidine in vitro, mitotic cells, pyknotic cells, and/or the number of lymphocytes and neutrophils in peripheral blood were measured in six calves. The median grain count of labeled cells and the DNA content of pyknotic nucleic were determined. After both doses there was an exponential decrease and subsequent recovery of the median grain count. The larger dose caused a temporary cessation of lymphoid cell division, reduced the output of nondividing small lymphoid cells, and probably imparied proliferation of neutrophil precursors. The results suggest that increased cell production during recovery was due to changes in the growth fraction and that feedback mechanisms acting on G0-G1 cells controled the proliferation of lymphoid cells.
Animals↗