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Biomedical subjects

A Gaunt

Publications and source records attributed to A Gaunt.

7 recordsLinked to original sources
PubMed1976

Effect of dose on renal diatrizoate concentrations in experimental acute renal failure.

In rats with glycerol-induced acute renal failure (ARF) and controls, renal concentrations of 125I-labelled sodium diatrizoate were measured 5 min after intravenous doses ranging from 14 to 1,800 mg/kg body weight. Renal concentrations of diatrizoate, at all doses, were much higher in controls than in ARF. A linear relationship existed between dose and renal concentration in ARF. In controls, at doses above 225 mg/kg body weight, the fraction of the dose present in the kidneys diminished and renal iodine content approached that observed in ARF. Differences in diatrizoate concentration which existed between cortical and medullary zones in healthy kidneys at low dises were progressively eliminated as dosage increased, consistent with the osmatic fiutryiv rggrvy of diatrizoate. In ARF, the pattern of intrarenal distribution at all doses was similar to that seen in controls at high doses, though concentrations in outer cortex were consistently slightly higher than those in inner cortex. These observations suggest continuing though reduced, filtration of diatrizoate in ARF by glomeruli already subjected to a large solute load.

Acute Kidney Injury↗
PubMed1976

Nephrographic density and renal diatrizoate content in experimental acute renal failure.

Reversible acute renal failure (ARF) was induced in rats by intramuscular injection of glycerol. In these animals and controls, renal concentrations of 125I-labelled sodium diatrizoate, injected intravenously in doses similar to those used clinically, were compared with the density of the nephrogram, subjectively assessed under carefully controlled conditions. Though a good statistical correlation existed between renal diatrizoate concentration and nephrographic density, individual variation was wide. At any given level of renal iodine concentration, nephrograms were judged to be denser in ARF than in controls. This was not due to differences in whole-body opacification or renal size, but was partly explained by the greater visibility of renal outlines on plain films in ARF. However, though at all doses of diatrizoate renal iodine concentrations were higher in controls, differences in nephrographic density were in general difficult to detect.

Absorptiometry, Photon↗
PubMed1976

Estimation of glomerular size and number from radiographs of the kidney.

In 32 adult human kidneys obtained at necropsy, renal demensions, measured from radiographs, were correlated with the number and cross-sectional area of glomeruli, determined by point-counting and computerized image analysis. Cortical area, measured from post-mortem angiograms, was poorly correlated with glomerular area and was not significantly correlated with glomerular number per kidney. The area of the whole kidney was poorly correlated with the number of glomeruli per kidney and was not significantly correlated with glomerular area. However renal dimensions, particularly total renal area, were highly significantly correlated with the product of glomerular area and number. This may allow glomerular numbers to be estimated in life but will not assess loss of glon the ageing kidney, the number of glomeruli per unit volume increased.

Adult↗
PubMedDate not supplied

Failure to prostaglandin A1 to modify renal diatrizoate uptake in experimental acute renal failure.

Acute renal failure (ARF) was induced in rats by intramuscular injection of glycerol. Forty-eight hours later prostaglandin A1 (PGA1) in a dose of 1, 5 or 25 microgram/kg bodyweight or phosphate buffer was infused intravenously over 15 min into these animals and controls. After 14 min, 125I-labeled diatrizoate was injected intravenously in a dose of 15 mg/kg bodyweight. Uptake and distribution of diatrizoate were measured one minute later in whole kidneys or kidney slices to provide indices of glomerular filtration. Diatrizoate concentrations were also measured in liver, plasma and washed red cells. Plasma volume was estimated with 125I-labeled albumin. PGA1 produced a dose-related increase in plasma diatrizoate concentration in ARF which was not accounted for by changes in uptake by the kidney, liver or red cells or by changes in plasma volume. It exceeded the relatively small increase in diatrizoate uptake which occurred in the kidney. Intrarenal distribution of diatrizoate did not change. These observations in the kidney suggest that intravenous PGA1 does not improve glomerular filtration in this model of established ARF.

Acute Kidney Injury↗