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A Gazarian

Publications and source records attributed to A Gazarian.

6 recordsLinked to original sources
PubMed2006

Bilateral hand transplantation: six years after the first case.

In this study we present our experience concerning bilateral hand transplantation. Two cases were performed: the first in January 2000 and the second in April 2003. Both recipients received the same immunosuppressive treatment, which was similar to those used in solid organ transplantation, including tacrolimus, prednisone and mycophenolate mofetil while antithymocyte globulins were added for induction. Both recipients presented two episodes of acute rejection (maculopapular lesions) in the first 3 months after transplantation; however, these were easily reversed after a few days increasing oral steroid doses and using topical immunosuppressants. The first recipient presented hyperglycemia and serum sickness while the second recipient suffered a thrombosis of the right ulnar artery and an osteomyelitis of left ulna. All the complications were successfully treated. Functional Magnetic Resonance Imaging (fMRI) showed that cortical hand representation progressively shifted from the lateral to the medial region in the motor cortex. After 6 and 2 years respectively, they showed a relevant sensorimotor recovery particularly of sensibility and activity of intrinsic muscles. They were able to perform the majority of daily activities and to lead a normal social life. The first recipient has been working since 2003. They are both satisfied with their grafted hands.

Adolescent↗
PubMed2001

[Definition and classification of basal joint osteoarthritis. A critical analysis and proposals. Treatment options].

Several definitions and classifications of basal joint osteoarthritis exist. Each of them can be criticized. The authors propose to define basal thumb osteoarthritis as osteoarthritis of the trapezometacarpal joint associated or not with lesions of scapho-trapezio-trapezoid and/or metacarpophalangeal joints. The proposed classification is derived from the Eaton-Littler classification. Stage O is identical to stage I of the Eaton-Littler classification: trapeziometacarpal instability without cartilage lesions. Stage I is osteoarthritis of the trapeziometacarpal joint only, without metacarpophalangeal deformity. Stage II is trapeziometacarpal osteoarthrites combined with reductible hyperextension deformity of the metacarpophalangeal joint. Stage III is trapeziometacarpal osteoarthrites combined with irreductible metacarpophalangeal deformity. Stage IV is identical to stage IV of the Eaton-Littler classification: combined trapeziometacarpal and scapho-trapezio-trapezoid osteoarthritis. The advantage of the proposed classification is that basal joint osteoarthritis is not only defined as real or potential (stage O) osteoarthritis of the trapeziometacarpal joint, but also includes precise evaluation of two other joints at the base of the thumb. This classification can be a guide for treatment options.

Carpal Bones↗
PubMed1999

[Reconstructive surgery of Blauth type III hypoplasia of the thumb].

Thumb hypoplasia type III according to Blauth remains a rare congenital malformation. Recently Manske has promoted reconstruction versus pollicization in the sub-type IIIA where a first carpometacarpal joint is present. However we felt that pollicization is the solution for sub-type IIB where the basal joint is absent. We have reviewed 14 cases of thumb hypoplasia type III, four of them being type IIIB. After performing a first step with a free vascularized second metatarso-phalangeal joint transfer, the secondary steps were identical in both sub-groups. After a mean follow up of five years, no great difference was found in the two sub-groups and basal stability was even better in type IIIB. However the results were functionally and cosmetically inferior to the ones observed after pollicization. When the relatives refuse pollicization or the patient consults late for functional improvement, reconstruction remains worthwhile.

Adolescent↗
PubMed1995

[Ulnar parametacarpal flap. Anatomical study and clinical application].

The ulnar border of the hand provides a new skin flap which is very useful in the reconstruction of defects of the palm of the hand and ulnar fingers. An anatomical study of the dorsal carpal branch of the ulnar artery and its various branches has led us to propose the ulnar parametacarpal flap either as a pedicle or free microsurgical transfer. The territory of the dorsal carpal branch of the ulnar artery allows harvesting of a simple sensitive skin flap or a composite flap comprising a bone or tendon island flap. Description of the distal communicating vessels with the ulnar collateral artery of the little finger extends the territory of the ulnar parametacarpal flap; based on a retrograde blood supply, it can reach the dorsal and palmar surfaces of the ulnar fingers. The authors present several clinical applications and define the place of this new flap among the various treatment options for the hand.

Hand↗
PubMed1992

[Tendinitis of the palmaris longus muscle. Apropos of 24 cases].

Twenty-four cases of flexor carpi radialis tendinitis were diagnosed between 1985 and 1989 by SOS Main Strasbourg. This condition typically occurs in women (75%) with a mean age of 47 years with no particular occupational activity who present with spontaneous and induced pain along the distal part of the tendon. Examination may reveal disturbances of cutaneous sensation in the territory of the palmar cutaneous branch of the median nerve and associated signs: cysts (10/24 cases), scapho-trapezium osteoarthrosis (3 documented cases). Medical treatment provided good results in 7 out of 9 patients reviewed after a mean follow-up of 15 months. In the event of failure, surgical treatment with opening of the compartment, provided 4 good results in 6 patients reviewed after a mean follow-up of 2 years 4 months.

Adult↗