[Interesting case no. 46. Bronchial foreign body].
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Adolescent↗
Biomedical subjects
A Geide
Publications and source records attributed to A Geide.
Somatostatin receptor scintigraphy in small-cell lung cancer: results of a multicenter study.
UNLABELLED: The aims of this study were to determine the accuracy of somatostatin receptor scintigraphy in the detection of the primary tumor and its metastases in small-cell lung cancer (SCLC) in a large patient population, and to investigate the course of somatostatin uptake in primary tumors during therapy. METHODS: In a total of 100 patients, 134 examinations were performed. Twenty-seven of the patients were examined before and after chemotherapy. Planar whole-body images were acquired 4 hr and 24 hr after injection of approximately 200 MBq (111)In-pentetreotide. SPECT of the thorax was performed after 24 hr. Tumor-to-background (T/B) ratios for the primary tumor were averaged from anterior and posterior projections. RESULTS: Compared to conventional investigations, somatostatin receptor scintigraphy (SRS) visualized the primary tumor with varying degrees of uptake in 96% of the examinations. Regional metastases and distant metastases were detected in 60% and 45% of the examinations, respectively. The uptake of the somatostatin analog by the primary tumor was significantly lower in the patients examined during chemotherapy as compared to those examined before treatment (T/B ratio = 1.94+/-0.79 versus 2.35+/-0.9, p < 0.005). A decrease in T/B ratio was noted in patients with remission at the time of SRS (from 2.40+/-1.56 to 1.63+/-0.72, p < 0.05). No difference in the pretreatment uptake of octreotide by the primary tumor was identified between patients with tumor progression and those with partial or complete remission. CONCLUSION: Somatostatin receptor scintigraphy has a high sensitivity in the detection of the primary tumor in SCLC but fails in the detection of metastases. Thus, SRS does not provide useful information for staging of SCLC. Since somatostatin uptake by the primary tumor is affected by chemotherapy, it may be used to follow up on the course of SCLC.
Adult↗
Mechanism of injury and anatomic injury as criteria for prehospital trauma triage.
Prehospital trauma triage should permit accurate identification and transport of patients with critical injuries to trauma centers without overloading these centers with patients having minor injuries. In most trauma systems a combination of physiologic criteria (Trauma Score [TS]), mechanisms of injury (MOI), and anatomic injury (AI) are used as prehospital trauma triage criteria. The purpose of our study was to assess the predictive value of specific MOI and AI in detecting critically injured trauma victims (Injury Severity Score [ISS] of more than 15) and determine the best combination of TS, MOI, and AI that produced the lowest percentage of undertriage and overtriage. Previous studies have examined only patients triaged to trauma centers; our study included all trauma patients regardless of destination. A total of 1,473 trauma patients was evaluated and transported by the emergency medical services system and studied prospectively during a nine-week period. Prehospital TS, specific MOI and AI, and final disposition and diagnosis were determined on all patients. The ISS was calculated on all hospital admissions. A total of 97 patients had an ISS of more than 15. Three hundred forty-one (23%) had one of the specific MOI studied; 102 (6.9%) had one of the specific AI studied. Four hundred twelve patients (28%) had at least one of the study MOI or AI.(ABSTRACT TRUNCATED AT 250 WORDS)
Adolescent↗