PubMed Health⌕ Search

Biomedical subjects

A Gelabert-Mas

Publications and source records attributed to A Gelabert-Mas.

32 records · Page 2Linked to original sources
PubMed1996

[Urocolpos: a cause of pseudo-incontinence in aged women].

Presentation of our experience in three cases of urocolpos (acquired pudendal lip fusion), a series numerically equivalent to the total number of cases published until now. All patients in our series were older women and presented complete fusion of the small pudendal lips, with only a small pointed puncture in the lower part of the vulva. The main clinical signs and symptoms in our series were: urinary infection in 100%, false incontinence in 66% due to output of urine retained in the vagina, a symptom that has not been described earlier, and acute urine retention in 33%. All patients were successfully treated by means of surgical loosening of the fusioned lips and application of topical estrogens. An analysis is made of clinical and pathoanatomical features which differentiate this entity from the sclerotic and atrophic lichen. Finally, an etiopathogenic hypothesis is raised to explain the fusion acquired by the small pudendal lips in the urocolpos.

Aged↗
PubMed1996

[Disappearance of migraine crises in two patients with male infertility treated with human chorionic gonadotropin/human menopausal gonadotrophin].

Two patients aged 52 and 31 respectively, treated for male infertility with gonadotrophins (LCG/LMG), showed marked improvement of their migraine crises associated with a typical aura which had been present since puberty. Changes in the number, motility and morphology of the spermatozoids were seen in the seminogram. The plasma concentrations of FSH, LH, testosterone an 17-beta oestrodiol were within normal limits. After three months of empirical treatment with LCG/ LMG (to stimulate spermatogenesis) the migraine crises ceased and the patients are still free of migraine after 32 and 26 months respectively. The relationship between migraine and the sex hormones is discussed, in the context of current knowledge of the psysiopathology of migraine and the beneficial effects obtained after treatment with LCG/LMG. We have not found any reference in the literature to the use of gonadotrophins in the treatment of migraine with a typical aura.

Chorionic Gonadotropin, beta Subunit, Human↗
PubMed1995

Serum lipoprotein changes after orchidectomy and treatment with oestrogens and luliberin analogues in male Sprague-Dawley rats.

The effect of androgen deprivation on lipoprotein profile and cardiovascular risk in men with advanced prostatic carcinoma is a matter of controversy. We describe an experimental model to evaluate the effects of orchidectomy and oestrogen and luliberin analogue administration on lipoprotein profiles in male Sprague-Dawley rats. Eighty rats were divided into three treatment groups and a control group. Results were compared with the scanty human data found in the literature. The oestrogen group was that which showed more differences compared with the control group, but its lipoprotein profile differed from that obtained in humans. Orchidectomy and luliberin analogue groups showed fewer differences than the oestrogen group, but a non-favourable lipoprotein profile in terms of cardiovascular risk was observed. There were important differences between humans and rats with regard to lipoprotein profile, suggesting that rats are probably not a good model for the study of atherogenic risk.

Animals↗
PubMed1995

Scrotal flap epilation in urethroplasty: concepts and technique.

PURPOSE: We describe our technique of scrotal epilation and the advantages of using the resultant glabrous scrotal skin in reconstructive urethral surgery. MATERIALS AND METHODS: An insulated needle model adapted to scrotal hair characteristics and a thermocoagulation current generator were used. RESULTS: An average of 3 epilatory sessions with a 4-week interval between treatments was the optimal schedule. No cutaneous infection was noted. CONCLUSIONS: The good results permitted the conversion of predetermined scrotal zones into wide areas of alopecia to be used as excellent skin flaps in complex urethral stenosis surgery in postpubertal male patients.

Equipment Design↗
PubMed1995

[Feminization: a paradoxical effect of stimulation with hCG/hMG in the infertile male].

Male feminization is an uncommon and complex phenomenon which occurs as a consequence of an imbalance in the effective oestrogen/androgen relationship. One of the many approaches used in the treatment of idiopathic male infertility is hCG/hMG stimulation. This paper reports one case of an infertile male treated with hCG/hMG after surgical correction of a varicocele, which resulted in a feminization effect evidenced by gynaecomastia and severe spermatogenesis blockade. When therapy was discontinued the feminization disappeared, a rebound phenomenon with normalization of most of the seminal parameters being seen. No other fully documented cases were found in the literature. Finally, the pathoetiological mechanisms involved in the feminization are analyzed and a revision is made of the causes that may cause it.

Adult↗
PubMed1993

[A prospective and randomized study of the complete response, index of recurrences and progression in superficial bladder carcinoma treated with mitomycin C alone versus mitomycin C and BCG alternatively].

The results of a comparative randomized study on intravesical chemoprophylaxis are presented. The study comprised 66 patients; one group of 29 patients received mitomycin C alone, while another group of 37 patients received mitomycin C and alternating BCG therapy. This latter treatment modality was found to achieve a slightly higher complete response rate and a much lower tumor progression rate. Although these results were not statistically significant (p > 0.05), they indicate that if the study were comprised of a larger series, the combined modality may be shown to achieve better results than the other modalities currently used.

BCG Vaccine↗
PubMedDate not supplied

Effect of antibiotic treatment on serum PSA and percent free PSA levels in patients with biochemical criteria for prostate biopsy and previous lower urinary tract infections.

BACKGROUND: Controversy exists as to the influence of inflammatory foci on total and free prostate-specific antigen (PSA) concentrations. The objective was to analyze the biological variations of PSA and percent free PSA (%f-PSA) in patients with biochemical criteria for prostate biopsy (PSA higher than 4 ng/mL and normal rectal examination) and compare them with the variation induced by antibiotic treatment in a cohort of patients with a history of lower urinary tract infections and no clinical evidence of prostatitis. METHODS: Ninety patients with a history of lower urinary tract infections, non-suspicious digital rectal examination and PSA between 4 and 20 ng/mL were analyzed. PSA concentration and %f-PSA were determined. Forty-five patients were treated with three weeks of ofloxacin, following which marker determination was repeated. All patients underwent ultrasound-controlled transrectal six-core prostate biopsy. RESULTS: Sixty-seven patients presented benign prostatic hyperplasia (BPH) (30 with prostatitic foci) and 23 cancer. Significant variations in PSA (6.97 ng/mL vs. 5.82 ng/mL, p=0.001) and %f-PSA (14.84% vs. 17.53%, p=0.01) were found only in the treated patients. These differences were significant for patients with BPH-associated prostatitic foci and not for patients with BPH or cancer. The tendency was for PSA to decrease (15 treated patients with PSA <4 ng/mL vs. six non-treated patients) and for %f-PSA to increase. The median variation of %f-PSA was greater than that of PSA. When the cutoff for %f-PSA was set at 25%, 18.9% of unnecessary biopsies after the first determination and 20% after the second could be avoided. By associating the reduction in PSA, up to 46% could be avoided in treated patients. CONCLUSION: Biochemical criteria for prostate biopsy may be modified in patients with a history of lower urinary tract infections due to variations greater than those explained by intraindividual biological variations, and may be influenced by the antibiotic treatment. These results suggest that subclinical inflammatory foci may influence PSA and %f-PSA.

Anti-Bacterial Agents↗
PubMedDate not supplied

[The preoperative diagnosis of complex renal cystic masses].

OBJECTIVE: To analyze the preoperative diagnostic methodology in a series of patients with complicated cystic renal masses in relation to the definitive anatomopathological findings. METHOD: 20 cases of asymptomatic complicated cystic renal masses in 19 patients submitted to surgical exploration are described. All cases were evaluated by US and CT. Fine needle punction-aspiration biopsy (FNPA) was done in 17 of the 20 masses and pre and postoperative anatomopathological analyses were performed. RESULTS: Following the Bosniak classification for complicated cystic masses, the US study showed two cases were type I, 5 type II, 10 type III, and 3 type IV, while the CT findings showed no type I, 8 type II, 9 type III and 3 type IV. The definitive anatomopathologic diagnosis was that of renal cell carcinoma in 11 cases. All but one (type II) of these 11 cases were Bosniak III or IV. Nine had a preoperative FNPA which showed malignant cells in two cases, while the remaining 7 were negative. The preoperative biopsy was negative in one of the 11 cases with renal cell carcinoma. The remaining 9 cases of complicated renal mass were simple cysts complicated by hemorrhage or infection. CONCLUSIONS: In our series, the use of the Bosniak classification system preoperatively highly correlated with the presumed benign or malignant nature of the lesion. FNPA biopsy, however, was not found to be very useful in the preoperative diagnosis of complicated cystic renal masses; it showed a sensitivity of 22% and a negative predictive value of 46.7%. Although the foregoing data have no statistical significance, a negative FNPA biopsy of a complicated cystic renal mass that raises reasonable doubts does not change the indication for a surgical exploration.

Adult↗
PubMedDate not supplied

[Cancer of the urothelium: background and characteristics of the care process related to the prognosis in a series of clinical cases].

We analyze the occupational and smoking histories of 98 bladder cancer patients in a Barcelona City general hospital (Spain). Only 12 patients had no history of occupational risk or of smoking; 38 had an occupational history associated to higher bladder cancer incidence, and 80 had been or were current smokers. Diagnostic delay and delay in the initiation of treatment are analyzed. Up to 24% of patients delayed visiting their general practitioner over three months after the onset of hematuria. Up to 21% took more than three months in seeing an urologist. Only 38% began treatment in hospital in the first three months after diagnosis. The greater proportion of infiltrative tumours is seen in patients below 65 years who were visited with delay for their hematuria.

Adult↗
PubMedDate not supplied

[One-day prevalence study of catheterized patients at a university general hospital. The SIUMAR project].

OBJECTIVES: This prevalence study analyzed urinary catheter use during a day in the Hospital Universitario del Mar of Barcelona. Furthermore, we investigated the indication and duration of urinary catheterization, the presence of urinary infection and the use of antibiotics. METHODS: All hospitalized patients were included in the study and all pertinent data were obtained from patient clinical history from every department. RESULTS: Overall, 14.75% of the patients were catheterized. The surgical departments showed a higher incidence (18%) than the other departments (14%). The catheter was indwelling for a median of 12.5 days and was frequently indicated for diuresis control (49.1%), 74.5% of the patients were catheterized at the hospital, 20% of these patients were febrile and had a positive urine culture, and only 14.5% had other infectious foci and a negative urine culture. CONCLUSIONS: There was no clear indication for catheterization in a high percentage of catheterized patients, which emphasized the need for continuous evaluation of catheter use. Antibiotics were used in excess in catheterized patients, the quinolones and the last generation of cephalosporins being the most widely utilized. The indiscriminate use of these potent antibiotics can cause undesired effects and increase hospital costs.

Adult↗
PubMedDate not supplied

[Incidental diagnosis of renal carcinoma. Impact on prognosis and survival].

A retrospective study was conducted in 206 renal carcinomas (RC) that underwent surgery between 1983 and 1992, evaluating those that were diagnosed incidentally. Among this series, 74 cases (35.9%) were incidental renal carcinomas (IRC). The complementary examination that allowed to reach a diagnosis was ultrasound in 58 (78.4%) patients, computerized axial tomography (CT) in 23 (17.6%) and intravenous urography (IVU) in 3 (4%). An evaluation is made of the main prognostic factors (nuclear differentiation grade and pathological stage) and the survival in these patients. The results obtained allow to conclude that IRC display an earlier pathological stage and lower nuclear differentiation grade than the other RC, the difference being statistically significant (p < 0.05). Also, the probability of survival in IRC-diagnosed patients is higher than in those diagnosed with non-incidental RC, the difference being statistically significant (p < 0.05).

Humans↗