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Biomedical subjects

A Gentric

Publications and source records attributed to A Gentric.

At least 37 records · Page 2Linked to original sources
PubMed1988

The importance of CD5-positive B cells in nonorgan-specific autoimmune diseases.

CD5, the human counterpart of Ly-1 molecules in the mouse, are detectable but weakly expressed on a minute fraction of circulating B cells. The number of CD5-expressing B cells is increased in patients with rheumatoid arthritis or primary Sjögren's syndrome. These cells are similar to those leading to chronic lymphocytic leukemia (they may be induced to produce multispecific autoantibodies). Multispecific autoantibodies have also been described in the early B cell repertoire.

Animals↗
PubMed1988

[The value of resorting to 2 technics for detecting anti-mitochondrial antibodies].

The presence of antimitochondrial antibody was determined by an indirect immunofluorescence assay (IIFA) and a quantitative complement fixation test (CFT) in 2,302 sera. This survey enabled us to calculate the sensitivity, specificity, positive and negative predictive values of the two techniques. It seemed valuable to use both techniques as the IIFA was more sensitive than the CFT whilst the CFT was more specific than the IIFA.

Antibodies↗
PubMed1986

[Sicca syndrome with severe renal insufficiency].

The interstitial nephritis associated with sicca syndrome is usually symptomless or responsible for mild renal impairment. The authors report five cases in which renal failure was severe, requiring haemodialysis in two patients. The physiopathological mechanisms and the treatment of interstitial nephritis in sicca syndrome are discussed. Corticosteroids improved renal function in three of these five patients.

Acute Kidney Injury↗
PubMedDate not supplied

[Anticoagulants in the elderly. Age-related factors].

HEPARINS: For unfractionated heparins, certain studies have demonstrated increased hemorrhage rates correlated with age and with renal function. Subcutaneous injections every 12 hours are as effective and less uncomfortable for the patient than continuous intravenous infusions. Low-molecular-weight heparins are currently contraindicated for curative treatment and their use is not recommended for prevention when the creatinine clearance is below 30 ml/min. OTHER ANTICOAGULANTS: The dosage of sodium daparanoid should be adapted to the renal function with regular surveillance of anti Xa activity. With hirudin, there is a risk of product accumulation in case of renal failure. For oral anticoagulants the relationship between old age and the frequency of hemorrhagic complications is still a subject of debate. ORAL ANTICOAGULANTS: The starting dosage should be reduced to one-half or one-quarter of the usual dose. The INR should be measured regularly, particularly since elderly subjects are highly susceptible to wide variations in INR irrespective of the cause. It is also advisable to carefully determine appropriate situations when oral coagulants should be used.

Age Factors↗