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Biomedical subjects

A Gilbert

Publications and source records attributed to A Gilbert.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Immune response during experimental periodontitis in mice].

Four groups of mice, each of a different genotype, were orally inoculated with Actinomyces viscosus. The resulting periodontal bone loss was monitored and the isotype specific anti-A. viscosus serum humoral immune responses measured by ELISA. Maximum periodontal bone loss occurred in all genotypes with inoculation of 1.6 x 107 colony forming units of A. viscosus. IgG and IgM isotype levels increased with inoculation of 1.6 x 107 colony forming units of A. viscosus in three of the four groups, indicating that IgA may be important in producing periodontal bone loss.

Actinomyces↗
PubMed1990

[Current treatment of malformations of the hand].

Since 1976, the author has operated over 700 congenital malformations of the hand. This treatment was modified in several ways: 1) The age of the patients has become younger, treatment sometimes beginning before one year of age (syndactyly, radial clubhand). 2) A number of techniques, such as the removal of a supernumerary thumb or pollicization, have become much more complex and standardized, thus greatly improving the outcome. 3) Other malformations (aplasia of the fingers), which were left untreated before, can now be treated by growing bone grafts or the transfer of toes.

Follow-Up Studies↗
PubMed1989

Increased muscle regeneration after repair of divided motor nerve with neuronotrophic factors containing glue.

Neuronotrophic factors (NTFs) directed to spinal cord motor neurons were collected in rats within silicone nerve regeneration chambers according to LONGO et al. (1983b). Unilateral addition of NTFs to the fibrin glue used for the repair of divided sciatic nerves improved locally nerve regeneration without affecting the controlateral side. Nerve regeneration was assessed by weight gain of the reinnervated muscles and by radioactive labelling of the acid-soluble phosphate fractions of both nerve Schwann cells and reinnervated muscle cells. Fast gastrocnemius and slow soleus muscles, the motor nerve of which had been repaired with added NTFs, were significantly heavier (21 and 28%) than their controlateral controls, and the metabolic dedifferentiation attendant on post-division nerve repair was less marked. It is suggested that this experimental nerve regeneration model is suitable to test potential nerve-active agents in vivo, under conditions close to the usual clinical setting, with, as ultimate goal, the improvement of the end-results of microsurgical repair of peripheral nerve in man.

Animals↗
PubMed1989

[Repair of cutaneous tissue loss of the arm. Development of the principles and technics].

Few sectors of reconstructive surgery have evolved as quickly over the past few years as the use of skin flaps, especially those used to cover losses of substance in the upper limb. This development is due to the increasing concern of surgeons about: 1) ensuring selective coverage of higher quality (the teguments used for the hand must be supple, thin and sensitive); 2) having reliable techniques; 3) reducing operating times and the duration of treatment.

Arm↗
PubMed1988

[The cubital flap].

The authors describe a flap with a pedicle derived from the dorsal branch of the ulnar artery. The ulnar artery gives rise to the dorsal ulnar artery 2 to 5 cm before the pisiform. This artery passes under the flexor carpi ulnaris muscle, accompanied by the dorsal branch of the ulnar nerve. It supplies an area 10 to 20 cm long by 5 to 9 cm wide on the ulnar side of the forearm and it also supplies the skin lying over the last three metacarpals on the dorsum of the hand and the Vth abductor. This artery also sends a branch to flexor carpi ulnaris and to the pisiform. It is now possible to trace a large flap in the forearm without interrupting the arterial axis. Large defects of the dorsum of the hand, wrist, thenar and hypothenar eminences can be covered by this pedicle or island flap. This artery is remarkably constant. Five clinical cases are presented.

Adult↗
PubMed1988

[The ulnar flap].

A new skin or fascial flap is described, based on the dorsal ulnar artery. In hundred fresh cadaveric forearms this vessel was constant with a diameter of 1 to 1.3 mm, passing dorsally from the ulnar artery deep to the flexor carpi ulnaris muscle. It supplies the skin and the fascia in the distal two thirds of the ulnar side of the forearm (length from 9 to 20 cm; width 1.5 to 10 cm). A flap based on this vessel can cover defects of the dorsal and palmar aspects of the hand and wrist, the thenar and the hypothenar eminence. It can be used as a fascial flap to avoid fibrosis around the median nerve and the tendons. The authors show the anatomy and some clinical cases.

Adult↗
PubMed1988

Tendon transfers for shoulder paralysis in children.

The treatment of shoulder paralysis in children is discussed and a new classification system is presented. The importance of treating contracture before considering tendon transfers is emphasized, especially for internal rotation contracture where subscapularis release alone results in the return of active external rotation is 47 per cent of patients. Specific transfers for external rotation, internal rotation and abduction are discussed.

Child, Preschool↗
PubMed1988

Indications and results of brachial plexus surgery in obstetrical palsy.

This article presents the first series with long-term results of a large number of patients. As a result, it is difficult to compare these results with anything but spontaneous recovery. In most cases, the end result after surgical treatment will be better than spontaneous recovery.

Brachial Plexus↗
PubMed1987

The anterior tibial artery flap: anatomic study and clinical application.

Satisfactory replacement of skin defects over the lower leg remains a difficult problem. Various forms of coverage, including, local rotation flaps, muscle flaps, and fascial and free flaps, have their specific indications and inherent disadvantages. In this work, a new axial skin flap based on perforating vessels in the territory of the anterior tibial artery is described. A series of 50 lower leg dissections was carried out in 25 fresh cadavers after latex injection into the femoral artery. Detailed studies of the cutaneous distribution of the anterior tibial artery showed that three main arteries perfuse the anterior lateral portion of the lower leg. The superior lateral peroneal artery and the inferior lateral peroneal artery interseptal cutaneous perforators arise at an average of 25.6 and 17.2 cm from the lateral malleolus, respectively. The superior lateral peroneal artery was present in 100 percent of the specimens, whereas the inferior lateral peroneal artery was present in 70 percent of the specimens. In their course, they give several muscular branches to the peroneus longus and brevis prior to perforating the fascia and arborizing in the subcutaneous tissues of the anterolateral portion of the leg. The average external diameter was 1.6 cm for the superior and 1.4 cm for the inferior lateral peroneal artery. The superficial peroneal nerve accessory artery is the third artery which contributes to the skin of the lower leg. It arises from the superior lateral peroneal artery in 30 percent of cases, from the inferior lateral peroneal artery in 40 percent, and from both in 30 percent. The artery runs along with the superficial peroneal nerve and gives several cutaneous perforators along its descending course. Several cutaneous axial flaps can be fashioned around this anatomy. The operative technique along with demonstrative clinical cases is presented followed by pertinent discussion.

Arteries↗