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Biomedical subjects

A Ginzburg

Publications and source records attributed to A Ginzburg.

15 recordsLinked to original sources
PubMed2005

Electrical impedance scanning for melanoma diagnosis: a validation study.

BACKGROUND: A multicenter study was conducted to test the ability of electrical impedance scanning to differentiate between benign and malignant skin lesions. The performance of a dual electrical impedance scanning/image analysis device was also assessed. METHODS: Electrical impedance scanning measurements of 449 preoperative lesions found on 382 patients and including 53 melanomas from the trunk and extremities were performed. Results were correlated with histopathologic findings. In addition, ABCD parameters for the lesions were automatically calculated by the system. RESULTS: Electrical impedance scanning detected melanomas of the trunk and extremities with 91 percent sensitivity and 64 percent specificity. Moreover, sensitivity of electrical impedance scanning was increased to 100 percent for in situ and thin melanomas of smaller size (n = 27). Visual examination identified as malignant only 67 percent of these early tumors (p = 0.002). Clinical examination detected 96 percent of the larger or thicker melanomas (n = 26), whereas electrical impedance scanning detected only 81 percent of them. Combined electrical impedance scanning and image analysis detected 100 percent of the melanomas, independent of their thickness, and with no significant decrease of specificity. Because of electrical differences between the head/neck and the rest of the body, the assessed electrical impedance scanning parameters were not adequate for the diagnosis of melanomas from the head and neck. CONCLUSIONS: A validation study proved the value of electrical impedance scanning as a noninvasive technique for detection of melanoma lesions of the trunk and extremities, specifically, of in situ and thin type. In addition, image analysis was shown to be a valuable, complementary procedure. New parameters should be designed to optimize the performance of electrical impedance scanning for melanomas of the head and neck.

Adult↗
PubMed2000

Surgical management of stable vitiligo: A review with personal experience.

BACKGROUND: Various modalities are available for surgical management of stable, localized patches of vitiligo, which are resistant to conventional medical treatment. Cutaneous surgeons often struggle to select among various methods of surgical treatment that include camouflage tattooing, melanocyte transplants, excision, and melanocyte culture. The advantages, disadvantages, and limitations of all the available modalities are reviewed. OBJECTIVE: The purpose of this review is to find out if any guidelines can be drawn regarding the surgical management of stable vitiligo. METHODS: This article is based on a review of the medical literature and the author's personal experience over the last decade. RESULTS: It is difficult to draw any fixed guidelines from this review. Treatment must be individualized depending upon the site and the extent of involvement. CONCLUSION: Although the retrospective nature of this article limits its validity, discussing the various therapeutic options is of value as continuing medical education. Surgical treatment may be individualized to obtain the best possible cosmetic result.

Cells, Cultured↗
PubMed1999

Another method of tie-over dressing for surgical wounds of hair-bearing areas.

BACKGROUND: We describe a modified tie-over dressing for any kind of surgical wound in the hair-bearing areas. METHODS: The long ends of the sutures are tied over the gauze pad to secure it. CONCLUSIONS: This modified technique of tie-over dressing can be utilized for the majority of surgical wounds in hair-bearing areas, such as the scalp. The dressing can be removed 1 or 2 days postoperatively by the patients, and the wound can be washed thereafter. The dressing helps ensure hemostasis, is simple to perform, looks tidy, and is well accepted by the patients.

Bandages↗
PubMed1996

Trichorrhexis nodosa: a manifestation of hypothyroidism.

A 23-year-old woman presented with diffuse white hair nodules, hair fragility, and the inability to grow long hair. Examination of specimens under the light microscope showed the morphologic characteristics of trichorrhexis nodosa. Results of tests revealed hypothyroidism. Treatment with a daily dose of 0.1 mg L-thyroxine sodium for six months restored euthyroidism and concurrently normalization of the hair defect was observed. The corrected hair defect observed after replacement therapy may point toward a causal relationship between hypothyroidism and trichorrhexis nodosa. To the best of our knowledge, this is the first report of trichorrhexis nodosa associated with hypothyroidism.

Adult↗
PubMed1987

Etretinate treatment of the nevoid basal cell carcinoma syndrome. Therapeutic and chemopreventive effect.

A patient suffering from the nevoid basal cell carcinoma syndrome, in whom various surgical and conservative treatment modalities had been tried previously, was placed on oral etretinate therapy. A therapeutic effect of the etretinate on existing basal cell carcinomas and a prophylactic effect in inhibiting new tumor formation were well demonstrated during the 13-month period of treatment.

Basal Cell Nevus Syndrome↗
PubMed1987

Generalized hair follicle hamartoma: the third case report in association with myasthenia gravis.

A 29-year-old woman, referred because of the development of diffuse papules and plaques on the face and progressive hair loss, was found to have generalized hair follicle hamartoma, a very rare condition previously described in only two female patients. All three patients also suffered from myasthenia gravis. The histological appearance of both the involved and uninvolved skin was similar to trichoepithelioma.

Adult↗
PubMed1986

Palmoplantar eruption associated with etretinate therapy.

Five psoriatic patients developed papular lesions of palms and soles, shortly after beginning treatment with etretinate. Histological examination in two cases was insignificant. The lesions disappeared without tapering the dose of etretinate. The fact that lesions appeared and subsided within a short period may explain why this unusual adverse reaction of etretinate therapy has not been reported previously.

Adult↗
PubMedDate not supplied

Use of storage phosphor imaging plates in portal imaging and high-energy radiography: the intensifying effect of metallic screens on the sensitivity.

The sensitivity of storage phosphor imaging plates (SPIP) at megavolt photon energies (60Co, 6-, 10-, and 18-MV radiotherapy beams) is studied both experimentally and by Monte Carlo radiation transport calculations. In addition, the same techniques are used to investigate the intensifying effect of metal screens on the sensitivity of the SPIP. The results provide evidence that the sensitivity of the SPIPs is proportional to the absorbed energy in the phosphor layer per cGy. The spectral sensitivity is calculated for photon energies between 10 keV and 20 MeV for various SPIP-screen combinations.

Aluminum↗
PubMedDate not supplied

Image information transfer properties of x-ray intensifying screens in the energy range from 17 to 320 keV.

The image information transfer properties of a number of x-ray fluorescent screens have been measured for x-ray energies from 17 to 320 keV. The detective quantum efficiency of the screens at each x-ray energy has been determined by separate measurements of the x-ray absorption efficiency and the statistical factor associated with the emission of optical photons upon absorption of an incident x-ray. Data have been recorded for both rare-earth phosphor screens and calcium tungstate screens. The value of the statistical factor for optical photon emission tends toward a constant value as the incident energy increases. Comparisons of the image information transfer properties are presented for several screens, which have been measured over a ten year interval. The utility of the screens for high-energy radiography is discussed.

Biometry↗