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Biomedical subjects

A Giobbi

Publications and source records attributed to A Giobbi.

At least 19 recordsLinked to original sources
PubMed1986

T-cell subsets in sarcoidosis: an immunocytochemical investigation of blood, bronchoalveolar lavage fluid, and prescalenic lymph nodes from eight patients.

T-lymphocyte subsets in peripheral blood, bronchoalveolar lavage fluid, and prescalenic lymph nodes from eight patients with sarcoidosis were evaluated with monoclonal antibodies. Both in lung and lymph nodes significant increases in helper T cells were demonstrated, except in patients with stage III pulmonary disease or with unaffected lymph nodes. A good statistical correlation was observed between the activity of the disease (expressed by an increased ratio of helper to suppressor/cytotoxic T cells) in bronchoalveolar fluid and in lymph node cell suspensions from each patient. A three-step immunoperoxidase staining reaction, performed on lymph node frozen sections, showed a prevalence of helper T cells both inside and around the granulomas. These findings confirm that sarcoidosis is characterized by increased activity of cell-mediated immunity in its different localizations.

Adult↗
PubMed1984

[Antituberculosis activity today].

The actual epidemiological aspects of tuberculosis suggest some changes in interventions once considered as essential. Then, at level of prevention, today antitubercular action must purpose to efface every extensive programme and the BCG-vaccination obliged; to definitively stop the isoniazid prophylaxis; to give up the usual sanitary practices against tubercular contagion. At diagnostic and therapeutic level, the old antitubercular structures are still indispensable to correctly tackle a problem that, though reshuffled, yet it still subsists. At last, we think that the socio-economic measures, taken when tuberculosis caused heavy consequences in patients activity, need a radical review. Antitubercular action, if we take away the out of time and out of need parts, can still contribute to qualify the interventions in defending or restoring health.

BCG Vaccine↗
PubMed1983

[Daniels' prescalenic biopsy in the diagnosis of pulmonary sarcoidosis].

Prescalene biopsy according to Daniels has proved an excellent method for the histological detection of pulmonary sarcoidosis. Cooperation over a period of 15 years between the ear, nose and throat division of the Bassini Hospital, Milan, and the Lombardy Provincial Anti-TB Consortia (especially that of Milan) led to the performance of 533 biopsies in about 1700 cases with morphological and radiological pictures indicative of pulmonary sarcoidosis. Overall positivity was 81%. The disease has five radiological stages: I, I + II, II, II + III, and III. Patients with hilo-mediastinal polyadenopathy predominated numerically. Histological positivity greater in group A (stages I & I + II), i.e. 86%, 74% in group B (stage II), and 60% in group C (stages II + III, and III). The dependence of positivity on stage was further confirmed when series from different consortia were compared. Stress is laid on the high productivity of the method, its low risk, and its ready application to patients usually in apparently good health, following their detection by mass screening or general pneumological examinations.

Adolescent↗
PubMed1976

Primary resistence of mycobacteria in tuberculosis patients.

Primary mycobactria resistance especially in some countries may be a serious obstacle to a successful therapy and the number of patients carrier of primary resistant mycobacteria remains almost at the same level in spite of the chemotherapeutic treatments and the usually rapid recover of the newly diagnosed cases. This may probably be attributed to the fact that the number of chronic patients, spitting resistant tubercle bacilli has remained almost the same, because these patients are eliminated little by little. In our country there is a constant regression of the morbidity, but not so rapid as expected, The newly diagnosed patients are generally young and, if well treated, they heal quickly and well; moreover, they are usually not so richly bacillised as they used to be once and the severity of their disease, globally evaluated, appears also reduced. The cultural positivity at the first admission into hospital is also diminishing. From all the above facts it is obvious that in order to eradicate tuberculosis it is necessary: First - to avoid creatin chronic patients; in order to reach this goal the treatment must be the most effective possible from the very beginning: INH and Rifampin. Second - to try to cure the chronic patients and to render them abacillary of, at least, to treat them intensively, with the purpose of inducing in the infecting flora a polyresistance which reners the mycobacteria hypovirulent, especially if it includes a R/AMP resistance over 40-gamma. Third - the role of the primary resistance in the epidemiology and the evolution of tuberculosis in the various countries and in the single patients, may be very different.

Adolescent↗
PubMedDate not supplied

Scalene node biopsy in diagnosis of intrathoracic diseases. Clinical notes.

Scalene node biopsy (SNB) still represents a useful diagnostic method in the difficult interpretation of hilar-mediastinal adenopathies. Of 858 sample cases of intrathoracic pathologies of various etiology, SNB indicated a high histological degree of positivity in sarcoidosis in stages I and I + II (86%) and in malignant lymphomas (91%). As a result, the authors believe that when faced with a process of localization prevailing in the hilar-mediastinal lymphatic system, the SNB is a preferable treatment and should be performed before a mediastinoscopy.

Biopsy↗