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Biomedical subjects

A Giorgi

Publications and source records attributed to A Giorgi.

13 recordsLinked to original sources
PubMed1990

Clinical effects of cyclosporin in dermatomyositis.

Auto-immune mechanisms, mostly cell mediated, have been described as the basic abnormality in polymyositis and dermatomyositis. We report here the case of a patient affected with dermatopolymyositis, resistant to therapy, who was treated with corticosteroids and cyclosporin. She presented with an infiltrative, erythematous rash on the neck, eyelids and cheeks and weakness of the proximal limb and cervical muscles. The dramatic and persistent response to cyclosporin obtained in this case represents a clear demonstration of the action of this drug in cases of dermatomyositis.

Azathioprine↗
PubMed1987

Identification of vaginal lactobacilli from asymptomatic women.

In the present work, carried out by means of phenotypic and genotypic tests, it has been demonstrated that none of the vaginal lactobacilli isolated from asymptomatic women were genetically close to L. acidophilus ATCC 4356. Strains of homofermentative lactobacilli were identified as Lactobacillus gasseri, L. jensenii and L. crispatus, while in the heterofermentative only one strain was classified as L. fermentum. Moreover a genetically homologous group of heterofermentative lactobacilli, that could represent a new species, were evidenced.

DNA, Bacterial↗
PubMed1986

[Antibacterial and antifungal activity of isoflurane and common anesthetic gases].

An in vitro analysis was conducted to investigate the hypothetical antibacterial and antimycotic activity of the common anesthetic gases (halothane, enflurane, isoflurane, methoxyflurane) in view of the clinical absence of bronchopulmonary pathology after inhalation narcosis despite the many risk factors involved. For this purpose scalar dilutions of the four gases were prepared on cultures of Klebsiella pneumoniae and Candida albicans and the antibacterial action of the gases was tested in vitro. Even with the weaker concentrations used, halothane and methoxyflurane totally inhibited both microorganisms. Enflurane had less effect on Klebsiella p. and almost none on Candida. Isoflurane, a new halogen ether anesthetic was found to have an excellent inhibitory effect. In conclusion it is hypothesised that the anesthetic gases considered might have an in vivo antibacterial activity considering the experimental results obtained in vitro.

Anesthetics↗
PubMed1983

Circadian rhythm of gastric inhibitory polypeptide (GIP) in man.

The diurnal variations of serum gastric inhibitory polypeptide (GIP), serum insulin, plasma glucagon, plasma glucose and serum triglycerides were studied for 24 hr in 6 healthy young men, consuming three meals and performing their usual physical activities. Serum GIP levels peaked after each meal and stayed significantly elevated from the peak after lunch till late night. Glucose and insulin showed early and short-lasting postprandial peaks, declining thereafter to basal values within a short time. Plasma glucagon was inhibited by the meal ingestion and fluctuated around the basal levels in the interdigestive periods. On the other hand, serum triglycerides tended to parallel GIP changes for most of the day, being significantly elevated starting from lunch consumption to late night. The present results suggest that GIP may have effects other than the insulinogenic one, being probably involved in the control of lipid metabolism.

Adult↗