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Biomedical subjects

A Gläser

Publications and source records attributed to A Gläser.

At least 19 recordsLinked to original sources
PubMed2001

[Our surgical heritage: the surgical school of Halle].

The knowledge of the historical development of surgery including its increasing specialization is important for our efforts to preserve the unity of surgery. In the past distinguished surgeons essentially influenced the progress of surgery. The list of the directors of the surgical department of the Halle university hospital in the last 150 years with the outstanding Richard von Volkmann is an excellent example for this influence and will be presented here.

General Surgery↗
PubMed1997

Technique and results of regional hyperthermic cytostatic arm perfusion for malignant melanoma.

Isolated hyperthermic cytostatic limb perfusion has been established as an efficient procedure for the treatment of malignant melanoma of the limbs. However, perfusions of the upper extremities are generally carried out much less frequently than would be expected given the distribution pattern of malignant melanoma and sarcoma. Thus, isolated descriptions of treatment results for perfusion of the upper extremities are not available. Between 1991 and 1994, arm perfusions using melphalan 1.0 mg/kg body weight were given to 14 patients with malignant melanoma, using the standardized method of perfusion described herein. Within an average observation period of 34.9 months (range, 12-65 months), 11 (78.7%) of the 14 patients who had M.D. Anderson stage II-IV melanoma remained free of local recurrence. In fact, 10 (71.6%) of the patients were still alive at the end of the observation period. None of the 14 patients showed any systemic adverse effects, although 1 patient developed a lymphedema 32 months after perfusion and 2 patients showed a postoperative temporary neurologic deficit. These results demonstrate that isolated perfusion of the upper limb with heat and melphalan under standardized conditions remains the treatment of choice for melanoma of the arm, as for melanoma of the leg, without a higher rate of complications.

Adult↗
PubMed1994

[Postoperative alkaline reflux after total gastrectomy for stomach cancer].

After presentation of postgastrectomy syndromes the methods for demonstrating the quantity of alkaline reflux are described. In 81 patients with gastrectomy the authors compare the reconstruction methods--named after Siewert/Peiper, Hunt/Lawrence, Schreiber and Schloffer--according to their reflux characteristics. The Y-Roux anastomosis shows better results than the Schloffer method.

Adult↗
PubMed1993

[Regional cytostatic perfusion of the extremities in patients with malignant melanoma and soft tissue sarcoma--therapeutic applications and results].

94 patients with malignant melanoma or soft tissue sarcoma of the extremities were submitted to isolated cytostatic limb perfusion. With palliative indication for treatment of malignant melanoma, the 5 year survival rate was 25% after perfusion with methotrexate and 50% after perfusion with melphalan. The adjuvant perfusion showed very good results, too. Furthermore, the authors report on their first experiences in regional cytostatic perfusion of soft tissue sarcoma and bone sarcoma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1992

[Multivisceral and extended resection in tumor surgery. Bone and peripheral soft tissue tumors].

Out of 92 patients with bone sarcoma and 640 patients with sarcomas of soft tissue 45 thoracic girdle amputations and 23 hemipelvectomies were performed. Radical surgery is the most effective prognostic factor. Recurrences stem from unradical operations which fail to include a compartment resection with a mantle of normal tissue in the case of soft tissue sarcomas or a resection of the sarcoma-bearing bone with normal surrounding tissue. Although multimodal therapies often cause tumour regression and necrosis, they do not stop recurrences if even minimal macroscopic parts of tumour have been left in situ.

Adolescent↗
PubMed1986

[Progress in tumor surgery].

The surgical approach to many organ cancers has undergone change in radicality in recent years. A growing trend has been recordable towards more individual surgical approaches, on the basis of interdisciplinary tumour therapy and as a result of widening knowledge of tumour biology and tumour pathology. In this context, attention has to be given to the widest possible range of factors of potential impact upon prognosis. Recommendations are given for therapeutic action, with reference being made to numerous examples of soft tissue and bone sarcomas, mammary carcinomas, parotid tumours etc. The surgeon with oncological training should be an expert partner and should maintain close cooperation with the radiotherapist and chemotherapist.

Combined Modality Therapy↗
PubMed1982

[Extension of the rosette test in the estimation of TAA-binding cells in breast cancer and mastopathy patients].

The antigen specific rosette test was used for the evaluation of a specific sensibilization of a tumour bearer to TAA. The frequency of the rosettes formed by peripheral blood leucocytes of breast carcinoma patients with antigen-coupled particles is significantly higher than that produced by leucocytes of normal donors. Following operation normally the number of TAA specific rosettes decrease, in 4 cases with recidives we found high numbers of TAA binding cells. In another 11/98 patients following ablatio mammae later than half a year we found positive test results and also in 17/60 patients with mastopathy. The clinical relevance of these results must be proofed in further investigations.

Antigens, Neoplasm↗
PubMed1980

[The adequate operation, an essential element of interdisciplinary cancer therapy].

Operative treatment plays a dominant role in our effort for cancer control. The results, e.g. in breast cancer, cancer of the stomach and colon, malignant melanoma, malignant teratoma of the testicle, mixed tumours of the salivary glands, and sarcomas of soft tissues demonstrate that local tumour relapses and/or local metastases may be avoided by adequate, sufficiently radical operative techniques.

Female↗
PubMed1977

[Tumours of the skin (author's transl)].

Clinical oncology as an interdisciplinary subject demands as intensive cooperation in the treatment of tumours of the skin between the dermatologist, the radiologist, and the surgeon. A survey is presented on the systemic order of tumours of the skin especially regarding the differential diagnosis and the surgical treatment of malignant skin tumours.

Basal Cell Carcinoma↗