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Biomedical subjects

A González-Mendoza

Publications and source records attributed to A González-Mendoza.

At least 19 recordsLinked to original sources
PubMed1999

Case report: cutaneous penicilliosis due to Penicillium chrysogenum.

A case of cutaneous penicilliosis in a young man, without immunological compromise is reported. The lesions in the neck were characterized by two exudative reddish-purple pruriginous and painless spots. Penicilliosis was diagnosed after serial laboratory studies based on the observation of hyphae by direct microscopic examination and histopathology. Cultures of the tissue obtained from the lesions, developed mould colonies with typical conidia of Penicillium chrysogenum, which was thermotolerant at 37 degrees C. The treatment with itraconazole was successful, and 15 days after cessation of therapy, no recurrence of infection was observed. The epidemiology of this type of mycosis is commented upon, as well as the rarity of infections produced by Penicillium, even as opportunistic pathogens. The isolation of P. chrysogenum from skin lesions is exceptional.

Adult↗
PubMed1993

Hyperkeratosis-hyperpigmentation syndrome: a confirmative case.

A 22-year-old female showing hyperpigmented spots and mild palmoplantar hyperkeratosis as leading features is presented. The diagnosis of Hyperkeratosis-hyperpigmentation syndrome, previously described by our group as an autosomal dominant trait, was unmistakable, thus permitting the corroboration of this genodermatosis.

Adult↗
PubMed1992

Chromoblastomycosis caused by Exophiala spinifera.

Exophiala spinifera is reported as a newly recognized agent of chromoblastomycosis. This case demonstrates that infections caused by dematiaceous fungi may be variable and that a single fungus may cause more than one type of infection. Chromoblastomycosis and phaeohyphomycosis represent extremes of a continuum of infections.

Chromoblastomycosis↗
PubMed1991

Deficiency in the incorporation of labeled thymidine and inhibition in the biosynthesis of interleukin-2 in lymphocytes obtained from Histoplasma capsulatum infected mice.

The incorporation of (3H) thymidine and the biosynthesis of interleukin-2(IL-2) were investigated in Concanavalin A (ConA) and histoplasmin stimulated lymphocytes from spleen of infected Balb/c mice with the yeast phases of Histoplasma capsulatum. The ability to incorporate (3H) thymidine of Con A stimulated lymphocytes in culture from spleen of Histoplasma capsulatum infected mice, as well as the IL-2 content present in the supernatants of that cultures, were depressed along the first three weeks of the experiments, but starting week five, normal values were restored or even discretly increased. Incorporation of (3H) thymidine in histoplasmin stimulated lymphocytes remained inhibited along the seven weeks the experiment lasted. Results showed that inoculation of H. capsulatum yeast in mice provoked a temporary immunosuppression on cell mediated immunity, that can be explained by means of the inability of T cells to produce enough IL-2 necessary for the proliferation of T cells in culture.

Animals↗
PubMed1986

Metabolic activity of phagocytes in experimental sporotrichosis.

Phagocytosis plays an important role as a protective mechanism against infections, since polymorphonuclear leukocytes (PMN) and macrophages are the first cellular lines opposed to aggressive microorganisms. In patients with sporotrichosis a diminished capability of killing engulfed yeast by their PMN has been described, but the origin of this deficiency remains unknown. In this work, partial aspects of the oxidative metabolism of PMN leukocytes and peritoneal macrophages of mongolian gerbils experimentally infected with sporotrichosis were studied. For this purpose the nitroblue tetrazolium (NBT) test as described by Baehner and Nathan (1) and myeloperoxidase activity measured according to Kaplow's method were utilized. The PMN and macrophages of mongolian gerbils infected with sporotrichosis showed increased reduction of NBT when compared with the phagocytic cells of normal ones, as is usually observed in most infections. Myeloperoxidase activity was diminished in both PMN and macrophages, but this diminution was statistically significant only in PMN leukocytes. These results show that part of the oxidative mechanisms of phagocytic cells can be impaired in experimental sporotrichosis, and could be correlated with the diminished fungicidal activity of PMN leukocytes obtained from patients infected with sporotrichosis.

Animals↗
PubMed1985

Use of human skin to demonstrate antinuclear antibodies in lepromatous leprosy patients.

A common finding in the sera of leprosy patients is the presence of antinuclear antibodies (ANA), but their specificity for autologous antigens is unknown. The aim of this work was to investigate the reactivity of these ANA toward the cell nuclei of human skin. ANA were investigated in the sera of 35 patients with lepromatous leprosy by immunofluorescence reactions performed with sections of human skin biopsies (autologous from each patient and healthy human skin obtained from plastic surgery procedures), and compared with the results obtained when rat liver was used as substrate. ANA titer, immunofluorescence pattern, immunoglobulin classes (IgG and IgM) and complement-binding capability were also investigated. When human skin sections were used as substrates, 30 out of 35 patients (85.7%) gave positive ANA tests; most of them gave a 1:4 to 1:16 titer for IgG with an annular pattern and 1:4 for IgM with an annular or a granular pattern. ANA of 30 patients bound C1q and 14 bound C3. However, when rat liver sections were used as substrates only 9 out of 35 cases (27.1%) gave positive ANA tests. These results show that human skin sections are a better substrate to demonstrate the ANA present in the sera of patients with lepromatous leprosy. Their significance in the pathogenesis of tissue damage remains to be investigated.

Adolescent↗