PubMed Health⌕ Search

Biomedical subjects

A Gorbman

Publications and source records attributed to A Gorbman.

102 records · Page 6Linked to original sources
PubMed1966

Rate of movement and redistribution of stainable neurosecretory granules in hypothalamic neurons.

Electrical stimulation of the olfactory tract of goldfish for one minute can deplete completely the stainable neurosecretory granules from cells of the preoptic nucleus as well as from their axons. Thus, in stimulated neurons secretory granules appear to move toward the neurohemal point of discharge at a rate of about 2 millimeters per minuite. Reaccumutlation of neurosecretory granules in depleted neurons to approximately normal numbers requires about 1 to 1.5 hours. Histological evidence indicates that, during the period of reaccumulation, granules move out of the perikaryon until normal granulation in the axons is achieved; finally, granulation of the perikaryon is restored.

Animals↗
PubMedDate not supplied

Isolation and characterization of melanotropins from lamprey pituitary glands.

Three peptides containing the melanotropin-core amino-acid sequence, YXMXHFRWG, were isolated from the pituitary glands of a modern representative of the most primitive vertebrates, the sea lamprey, Petromyzon marinus. MSH-A, a nonadecapeptide (NPELYQMNHFRWGQPPTHF), is free at both ends. MSH-B, an eicosapeptide (VQESADGYRMQHFRWGQPLP), is free at the N-terminus and amidated at the C-terminus. They differ strikingly from gnathostome MSHs in structure. The third peptide, with an apparent molecular weight of 15 kDa, was tentatively designated lamprey ACTH, based on a structural feature: the N-terminal 22-residue-MSH (SVSSPKYAMGHFRWGSPDKATI) is followed by four consecutive basic amino acids (RKRR) and a ACTH-like sequence (PVRPNTSDSPEIPDYAF--). MSH-B is 10 and 100 times more potent than alpha-MSH and MSH-A, respectively, in a frog skin assay in vitro, whereas the lamprey ACTH showed no melanotropic activity. Lamprey ACTH did, however, show corticotropic activity on the lamprey pronephric and mesonephric tissue.

Adrenal Glands↗