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Biomedical subjects

A Gorins

Publications and source records attributed to A Gorins.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Hormone receptors and precancerous lesions of the breast].

Little attention has been given to hormone receptors in preinvasive breast lesions. Results of biochemical analyses of duct in situ carcinomas reveal hormone receptors presence but with lower levels than in infiltrative lesions. Histochemical methods applied for lobular in situ carcinomas are not specific. The data would seem to warrant an investigation of the possible use of hormonal treatment in alternative of preventive surgery usually applied in preinvasive lesions.

Breast Neoplasms↗
PubMed1975

Comparative trial of nafoxidine and ethinyloestradiol in advanced breast cancer: an E.O.R.T.C. study.

A randomized clinical trial of nafoxidine, a non-steroidal oestrogen antagonist, and ethinyloestradiol in postmenopausal patients with advanced breast cancer produced objective remissions in 31% of 49 women receiving nafoxidine and in 14% of 49 receiving ethinyloestradiol. The differences in remission rates was almost significant (0.05 less than P less than 0.10). Life-threatening complications were more frequent with ethinyloestradiol than with nafoxidine but the latter produced specific toxic reactions on skin and hair that may limit its practical usefulness. Synthetic oestrogen antagonists may occupy a privileged place in the treatment of breast cancer, and other representatives of this new class of compounds should be accurately assessed in randomized clinical trials.

Administration, Oral↗