New findings about interrelations between vestibular receptors in the fog.
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Biomedical subjects
Publications and source records attributed to A Gribenski.
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The influence of the efferent vestibular system being eliminated, the spontaneous activity of single afferent fibres of the ampullary nerves of the horizontal and vertical anterior semicircular canals was recorded in the frog. By stimulating electrically the nerves of the vertical posterior canal, lagena or saccule as well as by sectioning these nerves and then using statistical methods, it is shown that the receptor-receptor fibres arising from the above mentioned receptors have generally an inhibitory influence on the afferent activity from the horizontal and vertical anterior canals.
In the frog we have recorded the spontaneous activity of single afferent fibres of the ampullary nerves of the left horizontal semicircular canal (HC) and vertical anterior canal (VAC) in isolated head preparations. The recordings have been made in 4 experimental situations: intact preparations; preparations whose brain was destroyed; preparations whose contralateral vestibular nerve had been cut between Scarpa's ganglion and the brain; preparations where either an ampullary nerve (that of the HC or of the VAC) or the utricular nerve had been cut contralaterally. From our results, it appears that the efferent vestibular system has a tonic influence on the afferent activity from HC and VAC; the influence of the part of the efferent vestibular system (EVS) activity depending on contralateral vestibular inputs is inhibitory, while the influence of the part of the EVS activity depending on ipsilateral vestibular inputs might be facilitatory.
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In the frog, the influence of both the part of the efferent system which depends on ipsilateral vestibular inputs and the receptor-receptor fibre system on the afferent activity of semicircular canals is either null or facilitatory. The receptor-receptor fibre system being inhibitory, it seems that the part of the efferent vestibular activity which depends on ipsilateral vestibular inputs is facilitatory, which agrees with previous results.
In the frog, the joint action of non-afferent vestibular systems [i.e. the efferent vestibular system and the receptor-receptor fibre system] on the afferent vestibular activity is null or very small. The receptor-receptor fibre system being inhibitory, it seems that the efferent vestibular system as a whole is facilitatory, which agrees with previous results.
The influence of the efferent vestibular system having been eliminated, the spontaneous activity of afferent fibres of the ampullary nerves of the horizontal and vertical anterior semicircular canals was recorded in the frog. By stimulating the ampullary nerve of one of these two canals while recording on the other, as well as by sectioning branches of the vestibular nerve and then using statistical methods, it is shown that receptor-receptor fibres have an inhibitory action on afferent activity from the horizontal and vertical anterior semicircular canals.
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We have studied the action of two ototoxic antibiotics (streptomycin and gentamycin) on the activity of the horizontal semicircular canal in comparison with those of penicillin and 7 g/1 NaCl solution, all of them being injected into the labyrinthic cavity. Only streptomycin and gentamycin have a specific action, and the one of streptomycin is much more important than the one of gentamycin.
The activity of efferent vestibular fibres has been recorded on the nerve of the left vertical anterior semicircular canal detached from its ampulla during rotations in the horizontal plane. Different types of responses have been found; they are noted in table I and pictured on fig. 2.
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