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Biomedical subjects

A Grillot

Publications and source records attributed to A Grillot.

10 recordsLinked to original sources
PubMed1988

[Thyroid function and trisomy 21. TSH increase and rT3 deficiency].

An excess of thyrotropin (TSH) with normal levels of tetraiodothyronine (T4) and of 3,5,3'-triiodothyronine (T3) was confirmed in the serum of 78 trisomy 21 children. A severe deficiency of 3,3',5'-triiodo-thyronine (rT3 or reverse T3) was observed and the decrease of the rT3/TSH ratio was highly significant. These new facts suggest that the rT3 deficiency plays a peculiar role in trisomy 21 (maybe through the regulation of one or few steps of monocarbons' metabolism). A systematic control of thyroid function (including the patient's rT3 level) is mandatory for the follow-up of every trisomy 21 patient.

Adolescent↗
PubMedDate not supplied

[Hypotensive effects of timolol in 86 patients (author's transl)].

Antihypertensive action of timolol (MK 950) was studied in 86 outpatients with essential, uncomplicated hypertension. Timolol is an effective hypotensive drug with significant lowering pressor effect. Timolol was given alone in 53 cases and in association with other hypotensive drugs in 33 cases: the mean dose was 20 mg daily for 8 months. At the end of treatment the mean diastolic pressure recumbert, standing, and after exercise had decreased by 10.2, 9.2 and 11 mmHg. Cardiac frequency had decreased by 13, 24 and 29 p. min lying, standing and after exercise. Side effects were rare, with cessation of treatment only in 4 cases.

Adolescent↗
PubMedDate not supplied

[Athletic activities and prevention of vascular risk factors].

Vascular accidents represent one of the most important causes of morbidity and mortality in France at the present time, and factors increasing the risk of such lesions are well documented: hypertension, smoking, and metabolic disorders (lipids, glucides, uric acid). Though genetic factors are definitely involved, most of them are acquired and related to our way of life, our type of civilisation, and, more particularly, to overeating and a sedentary life. Regular physical exercise of sufficient degree can considerably reduce the various factors which increase risk and, at the same time, diminish the frequency of these very serious vascular accidents.

Adolescent↗
PubMedDate not supplied

[A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)].

The effects of procyanidol oligomers on capillary resistance disorders in hypertensive and diabetic patients were studied. The drug was administered in a daily dose of 150 mg. Concordant results were obtained in two investigations as follows: during an open trial in 28 patients, capillary resistance (measured by the technique of Lavollay) rose from 15,4 +/- 1,8 cm Hg to 18,1 +/- 3,2 cm Hg (p less than 0,0005); and during a double blind trial versus placebo (25 patients) capillary resistance rose from 14,6 +/- 0,98 cm Hg to 18 +/- 3,35 cm Hg (p less than 0,005) in the treated group, while no significant variation was observed in the placebo group (15,5 +/- 1,30 cm Hg versus 14,7 +/- 1,3 cm Hg initially). The drug was well tolerated.

Adolescent↗