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Biomedical subjects

A Grivegnée

Publications and source records attributed to A Grivegnée.

13 recordsLinked to original sources
PubMed2006

Colorectal cancer (CRC) screening using sigmoidoscopy followed by colonoscopy: a feasibility and efficacy study on a cancer institute based population.

BACKGROUND: Advanced distal neoplasia found at sigmoidoscopy could be the marker for more proximal lesions. PATIENTS AND METHODS: In the setting of a screening clinic, subjects underwent flexible sigmoidoscopy. If no significant lesion was found, sigmoidoscopy was planned after 5 years. If an advanced neoplasia was found, colonoscopy was performed just after the first sigmoidoscopy and at 1, 3 and 5 years. If a non-advanced neoplasia was found, sigmoidoscopy was performed at 1, 3 and 5 years and followed by colonoscopy if advanced lesion was found. RESULTS: At first screening 1704/1912 (88%) subjects had a negative sigmoidoscopy, 104 (5.4%) had an advanced neoplasia, 96 (6%) had a non-advanced neoplasia and eight (0.4%) had invasive colorectal cancer (CRC). At follow-up examinations at 1, 3 and 5 years, among 170 subjects with advanced and non-advanced neoplasia, one developed invasive CRC and 47 (31.6%), advanced neoplasia. At 5 years, among 718 first negative sigmoidoscopies, 572 (80%) were confirmed negative and 97 (14%) had advanced neoplasia. Colorectal cancer status at 5 years could be checked for interval cancers in 97% of subjects and no CRC was diagnosed in subjects who did not attend sigmoidoscopy at 5 years. Comparison of the incidence of invasive CRC to the data of registries of the Netherlands and Luxembourg suggested that the incidence of CRC was decreased by 36%-46%. Seven of the nine CRCs were Duke's A and the two others were Duke's B and C. CONCLUSIONS: Screening with sigmoidoscopy followed by colonoscopy in case of positive sigmoidoscopy leads to substantial decreases in the incidence of CRC. Most CRCs found are at an early, curable stage of their development.

Aged↗
PubMed2000

Sunscreen use and intentional exposure to ultraviolet A and B radiation: a double blind randomized trial using personal dosimeters.

A previous randomized trial found that sunscreen use could extend intentional sun exposure, thereby possibly increasing the risk of cutaneous melanoma. In a similarly designed trial, we examined the effect of the use of sunscreens having different sun protection factor (SPF) on actual exposure to ultraviolet B (UVB) and ultraviolet A (UVA) radiation. In June 1998, 58 European participants 18-24 years old were randomized to receive a SPF 10 or 30 sunscreens and were asked to complete daily records of their sun exposure during their summer holidays of whom 44 utilized a personal UVA and UVB dosimeter in a standard way during their sunbathing sessions. The median daily sunbathing duration was 2.4 hours in the SPF 10 group and 3.0 hours in the SPF 30 group (P = 0.054). The increase in daily sunbathing duration was paralleled by an increase in daily UVB exposure, but not by changes in UVA or UVB accumulated over all sunbathing sessions, or in daily UVA exposure. Of all participants, those who used the SPF 30 sunscreen and had no sunburn spent the highest number of hours in sunbathing activities. Differences between the two SPF groups in total number of sunbathing hours, daily sunbathing duration, and daily UVB exposure were largest among participants without sunburn during holidays. Among those with sunburn, the differences between the two groups tended to reduce. In conclusion, sunscreens used during sunbathing tended to increase the duration of exposures to doses of ultraviolet radiation below the sunburn threshold.

Adolescent↗
PubMed1998

[Epidemiological aspects and surveillance of risky environments].

This short text concerns the epidemiological and factual aspects of the control of environment at risk for the health, especially the risks linked to cancers. The definitions of the carcinogens and the evaluation of their impact is shortly described. Strategies for a preventive approach are suggested and their application in the belgian context will be evaluated.

Environmental Health↗
PubMed1997

Melanoma and sunscreen use: need for studies representative of actual behaviours.

Experiments in rodents and humans have shown the ability of sunscreens to prevent UVB-induced skin cancers. Sunscreen use has thus become part of the panoply for melanoma prevention. However, results from epidemiological investigations indicate that sunscreen use could be a risk rather than a protective factor for melanoma. This article discusses possible explanations for discrepancies between experimental and observational results, suggesting that experiments did not reproduce usual human behaviours towards the sunlight. Also, marketing of sunscreens fosters unconsidered exposure to sunlight through associating sunscreen use to the acquisition of a 'safe suntan', or to the possibility to let children go naked into the sunlight without incurring sunburns. It has therefore been hypothesized that, because it prevents sunburn, sunscreen use allows prolonged exposure to sunlight. If this hypothesis holds, modern sunscreens with high protection factor could also represent a threat if their use is motivated by the desire of unrestricted exposure to sunlight. To explore this hypothesis, the design of a retrospective cohort study is presented, including children 5-7 years old, with the total body naevi count as principal endpoint. This study will have the opportunity to examine the qualities of modern sunscreens among young children.

Animals↗
PubMed1988

Noninvasive imaging of left coronary arteriovenous fistula.

We investigated a patient with coronary arteriovenous fistula (CAVF) by two-dimensional echocardiography (2-DE), cardiac Doppler, cardiac catheterization and nuclear magnetic resonance (NMR). These investigations clearly showed the abnormal vascular structures. NMR is another valuable noninvasive and safe method of confirming the presence of a CAVF.

Adult↗
PubMed1987

[Lipomatous hypertrophy of the interauricular septum. Morphological and electrocardiographical aspects].

The authors report a case of lipomatous hypertrophy of the interatrial septum diagnosed by echocardiography and confirmed by computerised tomography. The electrocardiogram showed an intra-atrial conduction defect considered to be virtually pathognomonic of this condition. The differential diagnosis and clinical implications of this abnormality, which is usually a fortuitous finding, are discussed in the light of recent publications. A precise diagnosis avoids confusion with other pathologies necessitating specific treatment such as intra-atrial thrombi and tumours.

Aged↗
PubMed1983

Cerebral ventricular volume during hyponatraemia.

In order to determine if the neurologic manifestations in chronic hyponatraemia result partly from brain oedema, we measured the cerebral ventricular volume before and after correction of hyponatraemia in eight patients with central nervous system manifestations. Only the three patients with seizures showed a clear change in the ventricular size and probably had brain oedema.

Adult↗