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Biomedical subjects

A Guareschi-Cazzullo

Publications and source records attributed to A Guareschi-Cazzullo.

15 recordsLinked to original sources
PubMed1997

Beta-endorphin and cholecystokinin 8 concentrations in peripheral blood mononuclear cells of autistic children.

beta-Endorphin (beta-EP) and cholecystokinin 8 (CCK-8) concentrations in peripheral blood mononuclear cells were measured in 12 drug-free autistic (AU) children, in 10 drug-free children with pervasive developmental disorders (PDD) and in 11 healthy controls. The aim of the study was to see whether or not there was an alteration of beta-EP and CCK-8 concentrations in this peripheral compartment, in which it has been suggested that secretion and regulation of the two peptides mimic those of neurons in the central nervous system. Mean beta-EP values were significantly higher in AU than in PDD and control children, while there were no differences in CCK-8 values of the three groups.

Adolescent↗
PubMed1994

Growth hormone response to growth hormone releasing hormone and to clonidine stimulation in peripubertal patients with major depressive disorder.

The responses of growth hormone (GH) to administration of growth hormone-releasing hormone (GHRH-1 micrograms/kg b.w.) and of clonidine (clon-2.5 micrograms/kg b.w.) and basal levels of somatomedin C (SmC) were measured in nine peripubertal patients with Major Depressive Disorder (MDD) and in 9 age- and gender-matched controls. Basal GH and SmC levels, and GH response to GHRH did not differ in patients and controls, whereas responses to clonidine were significantly higher in some and lower in other patients than in controls.

Adolescent↗
PubMed1993

Cortisol responses of depressed children and adolescents to clonidine administration.

The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to what has been observed in depressed adults. In controls, but not in patients, clonidine administration induced a transitory increase of the steroid.

Adolescent↗
PubMed1983

Movement-related brain macropotentials during skilled performances. A developmental study.

A developmental study of movement-related brain macropotentials (MRBMs) during a self-paced bimanual skilled performance task (Papakostopoulos 1980) was carried out. MRBMs were obtained from Fpz, Cz and right and left pre-central and electromyograms were recorded from the left and right flexor muscles of the forearms in 30 normal children ranging from 8 to 13 years of age. A consistent Bereitschaftspotential appeared in children of 10 years; in the younger children it was absent or it was positive at precentral and central locations. The motor cortex potential and P200 were present in all children. The skilled performance positivity (SPP), absent at 8 and 9 years, appeared at 11 years of age and was present in older children. The latency of P200 and SPP decreased with age. ANOVA tests showed a statistically significant age effect on performance, EMG rise time and MRBMs; MRBMs were not statistically influenced by time in the experiment: MCP and P200 increased in amplitude with improvement of performance. The results indicate different rates of maturation of the neuronal systems underlying the genesis of the various movement-related brain macropotentials.

Adolescent↗
PubMed1981

Effects of long-lasting sulpiride therapy on growth hormone secretion in mentally disturbed children.

The effects of chronic sulpiride therapy on growth hormone (GH) secretion were studied in 11 mentally disturbed children, aged 5 to 13 years, five with personality disorders, three with childhood psychoses, one with hysteria, one with anxiety reactions, and one with neurosis. The basal GH secretion and response to insulin-induced hypoglycemia were studied before the beginning of therapy and after ten days and three months of treatment with sulpiride (8 mg/kg body weight). No modifications in basal levels of GH or in the response to the stimulus were observed after ten days of therapy. After three months of treatment a blunted GH response to the stimulation was observed in three subjects, one of whom showed increased basal levels of GH.

Adolescent↗
PubMed1979

Psychopharmacological perspectives in childhood psychoses.

1. Neuroleptic drugs are still widely employed in childhood psychoses, but new experiences on a large number of cases in this field, have shown the usefullness of antidepressive drugs, either alone or associated with neuroleptics, also when depressive symptoms are not clearly evident. 2. This peculiar aspect, still noticed in pathological situations of less gravity, calls again attention to childhood depression and to the difficulty of identifying it. 3. The problem is developed and discussed as follows: a. The psychopathological features regarded from the psychodynamic point of view; b. The neurofunctional background in various ages; c. The pharmacodynamic characteristics of the drugs; d. The good results with lithium treatment in several cases allow the authors to outline some clinical pictures as well as biochemical markers as to recognize endogenous depression in childhood.

Antidepressive Agents↗
PubMed1978

Immunogenetics of Lennox-Gastaut syndrome: search for LD determinants as genetic markers of the syndrome.

In a previous work we demonstrated a strong association between HLA-B7 and the susceptibility to the Lennox-Gastaut syndrome. In this work we report some preliminary results obtained performing one-way mixed lymphocyte cultures in vitro between 15 unrelated children showing the typical EEG and clinical patterns of the syndrome. The same children were also tested against unrelated control cells from healthy donors. The low stimulation displayed by Lennox-Gastaut patients between them as compared with the higher stimulation found in patients/controls and controls/controls comparisons suggests the existence of an LD allele which may be associated with the disease.

Alleles↗
PubMedDate not supplied

Neuroendocrine investigation in children and adolescents with dysthymic disorders: the DST, TRH and clonidine tests.

A neuroendocrine study was conducted in eight children and adolescents with dysthymic disorders (three females and five males) and in eight age- and sex-matched psychologically normal controls. The dexamethasone suppression test (DST), TSH and GH responses to TRH stimulation and GH response to clonidine stimulation were studied in parallel in each patient. Depressive symptomatology was monitored with the Poznanski Rating Scale. The DST, TRH and clonidine tests revealed normal responses in each patient. TRH induced abnormal GH rises in five of the eight patients. There were no correlations between neuroendocrine parameters and degree of depression, age, sex or weight of the patients, age of onset, duration and family history of the disease.

Adolescent↗