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Biomedical subjects

A Guillard

Publications and source records attributed to A Guillard.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Development of Parkinson's disease].

After a number of good years, most patients with Parkinson's disease are faced with various problems. Some of these are due to the progress of the underlying anatomico-biochemical process and others to interference of the disease with dopatherapy. Motor impairment takes multiple aspects: disturbances of equilibrium and gait, akinesia with unusual presentation, involuntary movements, fluctuations of the motor status. Mental disorders may appear as depressive syndrome, mental confusion and/or varying degrees of intellectual alterations. Despite these disorders, the treatments that are currently available give these patients a normal life expectancy.

Humans↗
PubMed1989

Acute myeloradiculitis due to cytomegalovirus as the initial manifestation of AIDS.

A 26 year old male intravenous drug abuser presented with rapidly progressive paraplegia and total incontinence. CSF examination showed elevated protein level and pleocytosis. HIV testing was positive. Anti CMV titres were mildly elevated in serum and CSF. Death occurred 26 days after the onset of neurological signs. Necrotic and inflammatory lesions with numerous inclusion bodies characteristic of CMV were found in the roots of the cauda equina, conus terminalis and lumbar segments of the spinal cord. CMV subependymal encephalitis and HIV encephalitis were also present.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Remission of Lambert-Eaton syndrome over a 10-year period. Recurrence without evidence of tumor at autopsy].

A case of Lambert-Eaton's syndrome with onset 18 months prior to detection of an epidermoid cancer of the larynx is reported. Regression of the syndrome, and its total remission over 10 years without treatment following excision of the tumor, suggested a possible relationship as a paraneoplastic disorder. However, doubt was cast on any possible link by recurrence of the Lambert-Eaton's syndrome after 10 years remission, and the satisfactory course without treatment over the next 6 years combined with failure to detect any tumor recurrence or metastases, even at autopsy. The question raised is whether this is indeed a true paraneoplastic affection or a fortuitous association of an idiopathic form of Lambert-Eaton's syndrome and an infrequent cancer which, in addition, has never been reported at the origin of the Lambert-Eaton syndrome.

Aged↗
PubMed1988

[Neuropathologic study of 15 cases of multinucleated giant cell encephalitis in acquired immunodeficiency syndrome (AIDS)].

The central nervous system (CNS) of 40 patients who died of acquired immune deficiency syndrome (AIDS) between August 1982 and August 1987 was examined. In 15 cases, multinucleated giant cells (MGC) characteristic of Human Immunodeficiency Virus (HIV) infection were observed. In 3 cases ultrastructural examination disclosed HIV-like viral particles in the cytoplasm of some MGC. All cases with MGC showed, in addition, predominant white matter lesion: diffuse myelin pallor, multiple small, usually subcortical, necrotic foci, vacuolar myelopathy, proliferation of rod-shade microglia and microglial nodules, reactive astrocytosis, mineralization of the vessel walls. These changes, typical of HIV encephalitis, were isolated in 3 cases. In the other cases, they were associated with other AIDS-related CNS lesions, i.e., cerebral toxoplasmosis (9 cases), cytomegalovirus infection (5 cases), progressive multifocal leukoencephalitis (1 case), cryptococcosis (1 case) and cerebral lymphoma (1 case). The involvement of MGC with these lesions was remarkable.

Acquired Immunodeficiency Syndrome↗
PubMed1987

[Paralysis of the posterior branch of the radial nerve caused by a lipoma].

A case of compression of the posterior branch of the radial nerve by a lipoma is reported. This case is unusual because of the large size of the tumor (13 cm x 6 cm) and the interest of CT to exclude a liposarcoma. The risk of liposarcoma is greater with large size tumors. Reported 27 cases have been analyzed. The posterior branch of the radical nerve is particularly vulnerable because of the anatomic relationships. Thus benign extraneural sof-tissue tumors of the extremities may be responsible of nerves compressions.

Aged↗
PubMed1986

[Long-term study of 416 cases of Parkinson disease. Prognostic factors and therapeutic implications].

As L-Dopa was marketed in France in 1971 for treatment of Parkinson's disease we used 1971 to divide a sample of patients into 2 groups. Group 1 (152 patients) includes patients with diagnosis made before 1971 and group 2 (264 patients) with diagnosis after 1971. The prognostic factors were motor deterioration, intellectual deterioration and death. The prognostic variables include the neuro-psychological status at the onset of the disease and at the beginning of L-Dopa treatment. The statistical analysis is based on Kaplan-Meier estimate, Log-rank test and Cox's model. In group 2, 10 years after the beginning treatment of L-Dopa, motor deterioration affected 60 p. 100 of the patients. The poor variables were akineto-hypertonic type, severe akinesia, poor clinical result after one year. Intellectual deterioration was frequent: 30 p. 100 at 10 years. The poor variables were age over 60, depression or psychotic episodes occurring during the first year. The 10 years-survival rate was 64 p. 100 and was not different from that recorded in a French population of same age and sex distribution. The poor variables were severe akinesia, presence of a Babinski sign, poor therapeutic result after one year, occurrence of psychotic episodes during the first year. The interval between the onset of the disease and the beginning of L-Dopa did not have any prognostic value, whatever the response criterion. In group 1, the same prognostic factors were pointed out. Survival and intellectual deterioration were not different in the 2 groups, but in group 1, motor deterioration appeared earlier.(ABSTRACT TRUNCATED AT 250 WORDS)

Follow-Up Studies↗
PubMed1984

[Polyradiculoneuritis in a developmental flare-up of Behçet's disease].

A patient with Behçet's disease developed a polyradiculitis that was mainly motor. It was associated with an acute episode of mucocutaneous, articular and inflammatory symptoms and the neurological disorders regressed in a few months. A possible cause effect relationship is considered. Peripheral nerve lesions are rare in Behçet's disease. Only a few cases of polyneuritis radiculitis and mononeuritis multiplex have been reported.

Acute Disease↗