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Biomedical subjects

A Gwynne

Publications and source records attributed to A Gwynne.

3 recordsLinked to original sources

A review of 105 negligence claims against accident and emergency departments.

OBJECTIVE: To examine 105 successive negligence claims against NHS accident and emergency (A&E) departments in the United Kingdom and to highlight risk management points. METHODS: A systematic review of sociodemographic, clinical, and legal issues was conducted on each claim. RESULTS: 54 claims involved the missed diagnosis of a fracture because of failure to x ray or to interpret the films correctly; 27 claims alleged a missed or delayed diagnosis other than fracture and were mainly due to incomplete clinical examination or failure to x ray or to interpret the films correctly; 24 claims alleged clinical mismanagement in the A&E department; in 82 claims (78%) an SHO was allegedly responsible for the mistake. By the end of August 1996, 92 claims (87.6%) had been closed, of which 38 had been settled out of Court and 54 had not been pursued by the patient after disclosure of the records and--where appropriate--a repudiation of liability. Of the 13 claims remaining open, seven are considered to be defensible and six will have to be settled. CONCLUSIONS: SHOs employed in A&E departments need careful training and supervision, with ready access to senior medical advice, both clinical and radiological. Most errors leading to claims appear in retrospect to have been simple failures of history taking, physical examination, interpretation of radiographs, and communication. Poor quality notes imply substandard care. About half the claims were found to be indefensible.

Adolescent↗

Effects of cytochalasin B, colchicine, and vinblastine on progesterone synthesis and secretion by bovine luteal tissue in vitro.

Exposure of bovine luteal tissue to the anti-microfilament agent cytochalasin B inhibited both basal and LH-induced steroidogenesis, but had no effect on the portion of the progesterone secreted into the incubation medium. Addition of 10% calf serum to the incubation medium caused no significant increase in progesterone synthesis, but produced a significant increase in the portion of the progesterone found in the incubation medium. This increased secretion in the serum-containing medium was not altered by the presence of LH, and cytochalasin B was unable to prevent it. Exposure of the luteal tissue to the antimicrotubular drugs, colchicine and vinblastine, produced no alteration in synthesis or secretion of progesterone, even when LH was present, and neither drug inhibited the serum-induced increase in secretion of progesterone. These studies suggest that luteal cell microfilaments may be involved in LH-stimulated progesterone production while microtubules apparently play no direct role in progesterone synthesis.

Animals↗