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Biomedical subjects

A H Ansari

Publications and source records attributed to A H Ansari.

At least 19 recordsLinked to original sources

Transcutaneous electrical nerve stimulation for reducing narcotic use after cesarean section.

This study evaluated the potential efficacy of transcutaneous electrical nerve stimulation in reducing narcotic requirements following cesarean section. The total required dose of postoperative analgesic (meperidine) was found to be 511 mg in the experimental group and 456 mg in the control group. There was no significant difference in narcotic use or hospital stay between the experimental and control groups.

Adult

Cervical incompetence. A review.

Cervical incompetence is one of the main contributors to repeated pregnancy loss, accounting for approximately 25% of the cases. Typically it results in progressive cervical dilatation, leading to a painless second- or early-third-trimester abortion. In most instances cervical incompetence is the result of previous obstetric or gynecologic trauma; a congenital etiology is unusual. Despite the various reported diagnostic procedures, the obstetric history and frequent visual and digital examinations during pregnancy remain the most important factors in arriving at the correct diagnosis. In spite of the fact that numerous procedures have been advocated as treatment, the McDonald purse string closure technique is by far the most simple and effective corrective surgical technique, yielding an overwhelming number of successful pregnancies.

Female

Contraception and the cervix.

In the human and subhuman primates the uterine cervix plays an important role in the reproductive process by its permissive and inhibitory action on sperm migration from the vaginal pool into the cervical canal, the uterine cavity and the fallopian tube, the site of gamete unification and fertilization. This is accomplished through physico-chemical (amount, clarity, viscosity, pH, electrolyte composition, etc.) alteration of the cervical mucus in response to the circulating sex steroids. In an ovulatory cycle, shortly prior to and at the time of ovulation the cervical mucus becomes most receptive to the spermatozoa whereas at other times, specifically following ovulation, it becomes hostile to the spermatozoa and virtually impenetrable. This unique property of the cervical mucus may, in addition to the presently available techniques (diaphragm, cervical cap and intracervical devices), allow identification of such potential contraceptive modalities as: pH modifier - changing the pH of the cervical mucus from alkaline to acid around the time of ovulation; Electrolyte modifier - changing electrolyte composition of the cervical mucus to produce a mesh impenetrable to spermatozoa. Finally, development of a temporary localized tissue-fixed immune antibody to spermatozoa in the cervical mucus is within the realm of reality and deserves the necessary attention.

Animals

Successful management of post-cesarean-section acute pseudoobstruction of the colon (Ogilvie's syndrome) with colonoscopic decompression. A case report.

Although acute pseudoobstruction of the colon is a rare entity, a large percentage of the reported cases have occurred following obstetric and gynecologic surgical procedures. Early recognition is mandatory to avoid severe and potentially fatal complications and can allow successful decompression by means of colonoscopy, thus avoiding surgical intervention, as in the case reported on here.

Acute Disease

Chemical alteration of cervical mucus by electrolytes.

Scanning electron microscopy and energy-dispersive x-ray analysis have been used, together with conventional light microscopy and sperm penetration tests, to evaluate the alteration of cervical mucus composition and properties during the menstrual cycle and subsequent to exposure of cervical mucus to electrolytes in vitro and in vivo. Alteration of the electrolyte content of cervical mucus appears to offer a means for the predictable control of cervical properties and penetrability by sperm. This method may have clinical application in both reduction and enhancement of fertility in the human.

Animals

Electrolyte interactions in cervical mucus and their relationship to circulating hormone levels.

The changes in electrolyte composition of cervical mucus (CM) were monitored during the menstrual cycle, using scanning electronic microscopy (SEM) and energy dispersive X-ray analysis (EDX). Correlations were sought between the electrolytes present in CM, the physical characterisitics of the CM, and circulating levels of gonadal steroids and protein hormones. The results suggest that there is a definite relationship between circulating estrogen levels and electrolyte composition of CM, and also provide information on the secretion of electrolytes during the human menstrual cycle. This information will be of use in development of methods for fertility control directed to the uterine cervix.

Adolescent

Endometrial biopsy using a plastic curette (Mi-Mark).

Using soft (Mi-Mark) and sharp (Novak) curette endometrial biopsies were performed for the purpose of cancer screening and ovulation detection in five and 44 cases, respectively. The new devised plastic curette (Mi-Mark) when compared to the metal curette proved to be equally effective in obtaining an adequate endometrial sample for histologic evaluation. Due to the flexibility of the plastic curette endometrial biopsies were performed atraumatically and with the least amount of pain in most cases.

Biopsy

Sodium bicarbonate douching for improvement of the postcoital test.

In the hope of improving sperm survival within the cervical mucus, 93 infertile patients with unfavorable postcoital tests were advised to douche with a solution of sodium bicarbonate 30 to 60 minutes prior to sexual intercourse. In most patients observed, the repeatedly poor postcoital test improved remarkably, and 31 pregnancies have been achieved. In the majority of patients, the postcoital test was repeated on 2 subsequent days (without and with the benefit of sodium bicarbonate douching) with astonishing differences in the test results. In addition to pH changes, sodium bicarbonate douching resulted in significant alteration of the cervical mucus electrolyte components (detected by scanning electron microscopy and energy-dispersive x-ray analysis). The possible modes of action of sodium bicarbonate douching are fully analyzed.

Bicarbonates

End-to-end tubal anastomosis using an absorbable stent.

Using absorbable suture as a stent, end-to-end anastomosis of previously ligated or cauterized fallopian tubes was performed in 15 cases. Luminal patency of at least one fallopian tube has been achieved in all cases, and thus far seven pregnancies have occurred in six cases. The technique for inserting the absorbable suture into the distal and proximal portions of the tube is fully described, and the importance of repeated hydrotubations to maintain tubal patency is emphasized.

Adult

Liver tumors and oral contraceptives.

A possible causal relationship between oral contraceptives and liver cell adenomas has been postulated in the recent literature. In this presentation three additional cases are reported to support the existence of such an association. The possible etiologic causes for this newly described condition and specific diagnostic procedures for its accurate diagnosis are presented.

Adenoma

Recent advances in diagnosis and management of galactorrhea.

Using prolactin suppression (L-dopa) and provocative (thorazine) tests along with the clomid test the intactness of hypothalamico-pituitary axis was assessed in a group of eight patients with galactorrhea syndrome. Pituitary neoplasm was suspected in three cases on the basis of elevated plasma prolactin and its abnormal response to L-dopa, thorazine, and clomid tests. Trans-sphenoidal exploration of the pituitary gland in these three cases confirmed the diagnosis. In these cases, however, the commonly used parameters for evaluation of the pituitary gland (skull X ray, visual field measurement, echoencephalogram, etc.) failed to reveal the presence of the pituitary lesions. In two of the three cases, normal menses recurred following extirpation of the tumors and conception was achieved successfully. In the remaining patient the operation failed to remove the entire pituitary lesion and it was necessary to irradiate the pituitary gland as the patient continued to have persistent galactorrhea and hyperprolactinemia. The importance of the prolactin assay, and its response to stimulation and suppression tests for proper evaluation of galactorrhea was fully discussed.

Adult

Silicone rubber band for laparoscopic tubal sterilization.

In 1974, Yoon and associates (Am J Obstet Gynecol 120:132, 1974) described a new approach in which laparoscopic tubal occlusion was accomplished by utilizing the silicone rubber band technique. Recognizing the great advantages of the new technique in eliminating potential thermal injury associated with electrocoagulation, the authors have utilized the Yoon silicone rubber band technique in these institutions over the past 20 months. Thus far the procedure has been performed in 304 patients without any major complications. In the hope of eliminating and/or reducing possible pregnancy-failure rates, in 110 cases. In addition to application of the silicone band, the tube within the band was transected with non-electrical Seigler biopsy forceps. This, we believe, should provide an interesting long-term comparative study.

Female