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Biomedical subjects

A H Burstein

Publications and source records attributed to A H Burstein.

At least 55 records · Page 3Linked to original sources

Telemetric force measurements across the hip after total arthroplasty.

A telemeterized total hip prosthesis was implanted in one patient and force-data were obtained. Thirty-one days postoperatively, the magnitude of the joint-contact force during double-limb stance was 1.0 times body weight. During ipsilateral single-limb stance the joint-contact force was 2.1 times body weight, and during the stance phase of gait the peak force typically was 2.6 to 2.8 times body weight, with the resultant force located on the anterosuperior portion of the ball. During stair-climbing, the force was 2.6 times body weight. At peak loads, the angle between the resultant force and the axis of the neck was 30 to 35 degrees and that between the resultant force and the plane of the prosthesis was 20 degrees. During stair-climbing or straight-leg raising, the out-of-plane orientation of the resultant force increased substantially. These data provide information concerning the forces that must be sustained by prosthetic hip joints during a number of common activities of daily living within the first month after implantation. The results also provide insight into the progression of early recovery and demonstrate the variety of forces that are generated during this period.

Aged↗

A clinical and radiographic analysis of loosening of total knee arthroplasty components using a bilateral model.

Patients undergoing bilateral, simultaneous total knee replacement provide a unique opportunity to study the role of operative techniques in the development of radiolucent lines because variables such as age, sex, weight, diagnosis, and bone quality are internally matched when the result on one side is compared with that of the other. This allows more conclusive examination of operative factors, such as component alignment, level of tibial bone resection, and cement handling. With this as the objective, the clinical and radiographic results of the first 50 bilateral total knee replacements performed by the senior author were studied. Postoperative alignment was found to influence significantly the incidence of tibial radiolucent lines. Use of cement to reconstruct defects in the proximal tibia resulting from preoperative deformity consistently led to the development of radiolucent lines in the area of the defect. There was also indirect evidence that failure to achieve an intimate microinterlock at the bone-cement interface may play a major role in the development of tibial radiolucent lines.

Adult↗

The contributions of dietary protein and mineral to the healing of experimental fractures. A biomechanical study.

We examined the contributions of dietary protein and mineral to fracture-healing by assessing the mechanical properties of fracture callus in rats that were fed a diet that was deficient in or enriched by these nutrients. In order to isolate the effects of diet on fracture-healing, we developed a method for producing a standard closed femoral fracture with minimum-soft-tissue injury. Three groups of animals were studied. Group I was a control group, in which the rats did not undergo an operation. The rats in Group II underwent intramedullary pinning of the right femur, but no fracture was created. The rats in Group III underwent pinning identical to that used for Group II, after which a closed, transverse femoral fracture was produced. Immediately after surgery, the animals in each group were subdivided into five diet-treatment subgroups. Subgroup A received a regular diet; Subgroup B received a protein-free diet; and Subgroup C received a mineral-free diet that was lacking in calcium, phosphorus, and vitamin D. Subgroup D received a protein-supplemented diet that was composed of three times the calculated requirement of protein, and Subgroup E received a mineral-supplemented diet that was composed of three times the calculated requirements of calcium and phosphorus as well as a therapeutic dose of vitamin D, equivalent to that used in the treatment of osteomalacia. At the end of five weeks, the animals were killed and the right femur of each one was subjected to torsion-testing to failure.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

The effect of conformity and plastic thickness on contact stresses in metal-backed plastic implants.

Surface damage in polyethylene components for total joint replacement is associated with large contact stresses. An elasticity solution and finite element analyses were used to determine the influence of design parameters on the stresses due to contact in metal-backed components. For nearly conforming contact surfaces, it was found that the stresses in the plastic are very sensitive to clearance, that minimum plastic thickness of 4-6 mm should be maintained for metal-backed components, and that bonding the plastic to the metal backing reduces tensile stresses in the plastic at the edge of the contact zone.

Elasticity↗

The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study.

UNLABELLED: We studied the effect of demineralized bone matrix on the repair of large femoral diaphyseal defects in a rat model by clinical, radiographic, and biomechanical methods. A standard procedure was first developed to create segmental defects that did not heal and in which non-union developed consistently. The effect of demineralized bone matrix on repair was then assessed by physical examination, serial radiographs, and biomechanical studies to determine deformation to failure, stiffness, torsional strength, and energy absorption. By twelve weeks, the defects that had been treated with demineralized bone matrix showed satisfactory repair and remodeling in most animals based on clinical and radiographic evaluation. The biomechanical studies demonstrated that the bone induced by demineralized bone matrix had an energy-absorption capacity and stiffness equal to those of intact rat femoral bone. The bone induced by demineralized bone matrix achieved 35 per cent of the torsional strength of normal bone and an increased capacity to deform under load. These biomechanical properties are similar to those observed in the early stages of normal fracture repair. CLINICAL RELEVANCE: An effective, readily available alternative to autologous bone-graft material would have a variety of clinical uses in orthopaedic surgery, such as augmenting fusions, aiding in the repair of high-risk fractures, and filling or bridging bone defects. Demineralized bone matrix may provide an important tool for these purposes by inducing bone that has the mechanical properties of fracture callus. This would reduce the morbidity associated with harvesting autologous bone and have an advantage over allografts or synthetic biomaterials that require incorporation by the host before they can support mechanical loads.

Animals↗

Retrieval analysis of total knee prostheses: a method and its application to 48 total condylar prostheses.

A technique for the classification and quantification of damage in retrieved total knee prostheses is presented and applied to the examination of 48 removed total condylar-type knee replacements. The technique involves inspection of all metallic and polyethylene components for evidence of gross deformation, fracture, and damage to articulating surfaces. A grading system was developed to quantitate surface damage on polyethylene components. Results of the examinations are combined with patient variables (weight, activity level, radiographic findings, time of implantation, and results of histology performed on surrounding tissue) to determine correlations between clinical variables and the mechanical damage experienced by the prostheses. For the 48 total condylar-type prostheses, significant positive correlations were found for the surface damage correlated with the patient's weight and the time the prosthesis was implanted.

Biomechanical Phenomena↗

Telemetering in vivo loads from nail plate implants.

A system of multi-channel telemetry capable of broadcasting in vivo loading from orthopaedic implants is presented. Its use to monitor the two orthogonal bending moments about the nail plate junction of three implanted hip nails is described. Typical results from these cases in which the telemeterized implant was employed to treat proximal femoral fixation and osteotomy are given.

Biomechanical Phenomena↗

The material properties of immature bone.

The age-related material properties of developing immature canine bone were determined for the femora, tibiae, humeri, radii, and ulnae in animals from 1 wk of age to maturity. These properties included bone geometry changes, material tissue properties, and qualitative and quantitative morphological evaluations. All bones exhibited a two-phase growth cycle, an initial rapid phase (20 wk) followed by a substantially slower growth to maturation (48 wk). All properties showed age-related changes except bone tissue strain to failure.

Age Factors↗

Stress fractures of the pubic ramus. A report of twelve cases.

Twelve stress fractures of the pubic arch were seen in eleven patients who were joggers, long-distance runners, or marathoners. In two of the fractures there were complications of healing; that is, delayed union or refracture. With two exceptions, the lesions occurred in women between the ages of nineteen and forty-eight. In all of the patients the fracture was in the inferior pubic ramus near the symphysis pubis, and caused pain in the groin, buttock, or thigh. All fractures were non-displaced and easy to overlook on the initial radiographic examination; when a fracture of the pubic arch was clinically suspected but the radiographs were normal, a radionuclide bone scan was diagnostic. After identification of the fracture, running had to be curtailed until the symptoms disappeared in order for healing to occur.

Adult↗

Performance of the tibial component in total knee replacement.

UNLABELLED: In patients with deficient bone in the proximal end of the tibia, the mechanical support of a conventional total knee replacement may be inadequate. We have developed a custom design for use in situations in which there is extensive deficiency of tibial cancellous bone. To do this, we examined conventional and custom prosthetic tibial components using finite-element analysis. Several loading configurations were tested, and the worst loading conditions were found to be those in which eccentric loads were placed on the margin of the tibial component. The results showed that the stresses on the cancellous bone beneath a conventional-design prosthesis may be lowered if a metal tray and metal peg are employed. A salvage-design concept for revision in the presence of deficient cancellous bone was tested analytically and used successfully. This concept requires that some portion of the applied load be transferred directly to the tibial cortical shell. Stresses in the remaining cancellous bone were lowered by the combination of a thickened metal tray and a metal support buttress. CLINICAL RELEVANCE: This study demonstrates the advantage of metal trays for the tibial plateau and suggests that they should be used whenever the supporting tibial bone is insufficient. In knees in which there are large defects in the bone, direct transfer of the load to the cortical shell through the prosthesis, made possible by a custom design, appears to be necessary.

Aged↗

Mechanical properties of poly(methyl methacrylate) bone cements.

Samples of low viscosity poly(methyl methacrylate) (PMMA), graphite reinforced PMMA, and graphite reinforced low viscosity PMMA were evaluated for their compression strength and fracture toughness. These results were compared with two currently used plain PMMA bone cements. There were no statistically significant differences in compression strength between the five cements. Graphite reinforcement of plain cement produced a 32% increase in fracture toughness over plain cement. Graphite reinforcement of low viscosity cement also produced a significant increase in toughness (31%) over low viscosity cement with fiber reinforcement. However, low viscosity cement demonstrated significantly less fracture toughness than plain PMMA.

Analysis of Variance↗

The effect of carbon fiber reinforcement on contact area, contact pressure, and time-dependent deformation in polyethylene tibial components.

To study the mechanical behavior of a commercially available UHMWPE reinforced with carbon fibers, measurements of contact area, contact pressure and time-dependent deformation were made on tibial components from a contemporary total knee replacement loaded to physiological levels. For comparison, similar measurements were performed on identical components manufactured from plain UHMWPE. Contact area and pressure results reflected the increased stiffness of the carbon-UHMWPE material, with smaller contact areas and generally higher contact pressures versus the plain UHMWPE at the same load. Stresses in both materials under the contact area approached or exceeded the yield stresses for the materials when the physiological load was high or the radius of the femoral component indenter decreased (similar to flexion of the knee). Time-dependent deformation over a 24 h period was reduced significantly in the carbon-UHMWPE components for a high physiological load.

Arthroplasty, Replacement, Knee↗