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Biomedical subjects

A H CRUICKSHANK

Publications and source records attributed to A H CRUICKSHANK.

14 recordsLinked to original sources
PubMed1965

BENIGN LYMPHOEPITHELIAL SALIVARY LESION TO BE DISTINGUISHED FROM ADENOLYMPHOMA.

In a collection of 11 cases, the benign lymphoepithelial lesion presented clinically in every case as a tumour of a salivary gland. In eight cases the parotid was affected, in two a palatal salivary gland, and in one the submandibular gland was affected. Microscopically the lesion consisted of a mixture of lymphoid and epithelial components and, although the appearances in several cases suggested lymphosarcoma or reticulosarcoma, the arrangement of the epithelial component in characteristic islands (epi-myoepithelial islands) indicated the benign nature of the lesion. In one case incomplete excision of a lesion of the palate was followed by a recurrence that was cured by a radium mould. The microscopical appearances of the benign lymphoepithelial lesion were identical with those of the salivary lesions of Sjögren's syndrome but in all the cases the lesion was an isolated one and the sicca syndrome was absent.

Adenolymphoma↗
PubMed1963

MALIGNANCY IN SCARS, CHRONIC ULCERS, AND SINUSES.

A collection of 44 cases of malignancy in scars, chronic ulcers, and sinuses, included the following predisposing lesions: a 20-year-old sinus from ischial bursitis, a 23-year-old bed sore, a congenital gumma about 50 years old, three burn scars (average age of scar 56 years), 11 sinuses from chronic osteomyelitis, and 27 chronic ulcers of the leg. The osteomyelitis cases included two rapidly fatal sarcomas, one in a sinus present for 16 years, the other in a 20-year-old sinus. The remaining tumours in this group were squamous carcinomas that developed in sinuses with an average duration of 37 years. In the cases of varicose ulcer, the ulcer had been present on the average for 21 years before the onset of malignancy. One patient in this group, with an ulcer not known to be more than five years old, developed a sarcoma that was fatal in six months. The biopsy diagnosis was difficult in 17 cases, including one of the cases of sarcoma. The difficulty was greatest in cases of osteomyelitis. The conditions discussed are now known as ;Marjolin's ulcer'. In the present series, the degree of malignancy in tumours arising in scars may be low but the malignancy of tumours arising in chronic ulcers and sinuses may be high.

Burns↗
PubMed1962

Cystadenoma and cystadenocarcinoma of the pancreas.

The pathological findings in 14 cases of cystadenoma and three cases of cystadenocarcinoma of the pancreas have been studied in relation to the clinical effects. All the patients were women, and their ages ranged from 13 to 90 years. Four tumours measuring 2 to 4 cm. in diameter had not caused symptoms or signs. Tumours from 7 to 12 cm. in diameter had been felt in the upper abdomen and half the patients with such tumours had complained of pain. In two cases with large tumours there was severe bleeding into the alimentary canal. THE CYSTADENOMAS WERE OF TWO TYPES: 1 Tumours with small loculi lined by cubical epithelium, in which there was little secretion of mucus by the epithelium but abundant mucoid stroma. There were six of these tumours and we have no evidence of malignant change in this type. 2 Tumours with relatively large cystic spaces filled with mucus and lined by tall, mucus-secreting epithelium. There were eight of these, and the possibility of malignant transformation in this type of tumour is indicated by the finding that in three cases of cystadenocarcinoma two appeared to have been preceded by simple mucus-secreting cystadenomas. Signs of recent or old haemorrhage were common in both types of cystadenoma and also in the cystadenocarcinomas.

Cell Transformation, Neoplastic↗
PubMed1961

The pathology of 111 cases of primary hepatic malignancy collected in the Liverpool region.

The clinical records and preserved specimens of 111 cases of primary malignant disease of the liver have been analysed. All were diagnosed in the Merseyside area, chiefly in Liverpool and Birkenhead, and all but nine were Europeans. Necropsy was done in 89. The tumours consisted of 108 carcinomas, two sarcomas, and one mixed tumour. Liver cell carcinoma was nearly four times more frequent than carcinoma of the intrahepatic bile ducts. Both types were commoner in males, the difference between the sexes being greater in the case of liver cell carcinoma. Predisposing conditions included portal cirrhosis, haemochromatosis, and cystic malformations of bile ducts. The gross and microscopic appearances are described and the pathological effects discussed. Liver cell carcinoma tends to invade and permeate veins within the liver but seems, nevertheless, to remain limited to the liver for longer than carcinoma of the intrahepatic bile ducts. Liver cell carcinoma is more characteristic microscopically. The commonest occupation among the male cases was seafarer.

Bile Duct Neoplasms↗