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Biomedical subjects

A H Esser

Publications and source records attributed to A H Esser.

5 recordsLinked to original sources
PubMed1991

Inhibition of pyruvate dehydrogenase complex (PDHC) by antipsychotic drugs.

The effects of 11 antipsychotic drugs on the pyruvate dehydrogenase complex (PDHC) prepared from bovine heart and rat brain were investigated. All inhibited PDHC to varying extents. With clinically equivalent doses, chlorpromazine and thioridazine inhibited the most and fluphenazine and thiothixene the least. The relationship of degree of inhibition of PDHC by neuroleptics to clinical improvement of 32 outpatients treated with acetazolamide and thiamine (A + T) ancillary therapy for chronic mental illness suggests that patients treated with psychoactive drugs that inhibit PDHC the least are most likely to have a favorable response with A + T treatment.

Acetazolamide↗
PubMed1989

Acetazolamide and thiamine: an ancillary therapy for chronic mental illness.

Twenty-four chronic schizophrenic patients were treated successfully with the addition of acetazolamide and thiamine (A + T) to their unchanged existing therapies in a double-blind, placebo-controlled crossover study. Therapeutic effects were measured by the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms. Overall, 50% of the patients showed improvement on all assessment scales. No untoward effects occurred in these patients or in patients in previous studies who have been treated continuously with A + T therapy for as long as 3 years.

Acetazolamide↗
PubMed1976

Acupuncture tonification: adjunct in psychiatric rehabilitation.

Our aim was to "tonify" chronic psychiatric patients, i.e., restore their physiological homeostasis and sense of well-being by using standardized acupuncture. In eighteen subjects, eleven diagnosed as schizophrenic, feelings of well-being lasting no longer than three days were obtained in over 60% of the treatments. In more than two-thirds of the cases normalization of blood pressure values tending to 120/80 was evident. Degree of physiological change did not appear to be associated with overall psychological improvement; neither was the number of treatments associated with long-term improvement. For future studies, increased treatment frequency and less rigidly controlled procedures are suggested.

Acupuncture Therapy↗
PubMed1976

Automated short range locator system.

A computer operated system is described for determining the location of a subject fitted with a small sensing coil and telemetry transmitter. The system uses the geometric factors inherent in the value of the mutual inductance of a fixed and moveable coil. Results of a two-dimensional system are shown.

Animals↗