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Biomedical subjects

A H Johnson

Publications and source records attributed to A H Johnson.

At least 19 recordsLinked to original sources
PubMed1979

B cell antigens of Black Americans.

Fourty-four unrelated North American Blacks and one Black family were tested for B-cell specific antigens with 7th International Workshop antisera. DR specificities were clearly defined in this group, but were generally less frequent than reported for Black Americans in the 7th Workshop report and were most similar in frequency to those reported for African Blacks. Five new B-cell specificities (DuB40-43, 45) were identified. In contradistinction to Caucasians, Black Americans type for HLA-D with homozygous typing cells failed to exhibit strong linkage disequilibrium between D and DR types.

B-Lymphocytes↗
PubMed1979

Teaching attitudes and skills in microcounseling.

This is the first of two papers describing salient aspects of the behavioral science orientation curriculum in the Charleston Family Practice Residency that focus on developing counseling skills. Two short lectures preceding microcounseling training are summarized. One short lecture outlines the myth of medical management and differentiates a "problem oriented" from a "client oriented" model. The second short lecture presents the definition of communication as a culturally structured complementary series of behaviors. Microcounseling, which is an experientially oriented series of communication exercises, is presented in detail. The article concludes with a discussion of the specific advantages and disadvantages of this particular learning format and its implications for the practice of family medicine.

Communication↗
PubMed1979

Assessing counseling skills and attitudes in family practice residents.

This is the second of two papers describing portions of the behavioral science orientation curriculum that focuses on assessing changes in counseling skills and attitudes in Charleston family practice residents. The measurement of counseling skills and attitudes is accomplished through a 38-item multiple choice instrument. The basic types of items composing the instrument are delineated. Pre and post-testing data are presented over a five-year period, 1973-1977. Three-year follow-up data are presented for the residency class entering in 1975. These data are discussed from two perspectives: (1) their function in teaching physician awareness of counseling style, and (2) their function in assessing changes in physician counseling profiles.

Attitude of Health Personnel↗
PubMed1978

B-lymphocyte alloantigens associated with systemic lupus erythematosus.

We examined B-lymphocyte alloantigens in 41 patients with systemic lupus erythematosus and 184 controls, using a panel of 47 pregnancy serums, and compared reaction frequencies of individual serums. One serum, la-715, reacted with B lymphocytes from 75.6 per cent of patients and 14.1 per cent of controls (Pc less than 0.005, relative risk 18.8). Twenty-eight of the patients were also typed with a panel of HLA-D-related serums from the Seventh International Histocompatibility Workshop, HLA-DRw types assigned, and compared to 490 Workshop controls. Both HLA-DRw2 (57.1 per cent vs. 26.4 per cent, Pc less than 0.004) and HLA-DRw3 (46.4 per cent vs. 22.2 per cent, Pc less than 0.03) were increased in systemic lupus erythematosus. This study demonstrates that select B-lymphocyte alloantigens, which are controlled by genes in the major histocompatibility complex, are present in increased frequency in systemic lupus erythematosus.

Adolescent↗
PubMed1978

B lymphocyte antigens in sicca syndrome.

All individuals tested in this study with sicca syndrome, a human autoimmune disease, bear two immunologically distinct and genetically unrelated B lymphocyte antigens that appear similar to the immune response associated (Ia) antigens of the mouse. The genes coding for these two antigens are present in only 37 and 24 percent of normal controls. In animal models Ia antigen genes are closely linked to immune response genes. Our findings suggest that two such genes may be required for the development of sicca syndrome.

Adolescent↗
PubMed1978

The distribution of HLA antigens in the Motilones Indians of Venezuela.

The HLA antigen profile of the Bari and Yupa Indians who live in the Motilones Valley on the border between Venezuela and Colombia was studied. Both groups showed very limited polymorphism. HLA--A1, A3, A11, Aw23, A25, A26, A29, Aw30, Aw32, and Aw33, and HLA--B7, B8, B12, B13, B14, B17, B18, Bw22, and B27 were not observed in either population.

Gene Frequency↗
PubMed1978

Characteristics of malignant phenotypes in familial polyposis.

Numerous clinical syndromes associated with multiple polypoid lesions of the gastrointestinal tract have been described. These syndromes generally have two striking characteristics: 1) Most of them are familial with the disease being inherited as a mendelian autosomal dominant trait, and 2) most of the affected patients have moderate to marked propensity to develop gastrointestinal carcinoma, usually of the large bowel. Whereas previously many of these syndromes were thought to be well-defined entities, it now appears that there is overlap between certain of them such that they appear more similar than different. The clinical and pathologic characteristics of the various gastrointestinal polyposis syndromes and the methods of diagnosis and treatment are reviewed in this manuscript.

Adolescent↗