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Biomedical subjects

A H Qizilbash

Publications and source records attributed to A H Qizilbash.

63 records · Page 4Linked to original sources
PubMedDate not supplied

Ewing's sarcoma. Cytologic features in fine needle aspirates in two cases.

The cytologic findings of two cases of Ewing's sarcoma in fine needle aspiration biopsies are presented in relation to the subsequent histologic findings. The malignant cells were arranged in monocellular layers, pseudorosettes and in perivascular palisades in a fibrillar background. The nuclei were monomorphous with small nucleoli and finely granular chromatin. These features may be helpful in distinguishing this tumor from other small-cell neoplasms; the differential diagnosis between Ewing's sarcoma and such tumors is discussed.

Adolescent↗
PubMedDate not supplied

Basal-cell adenoma of parotid. Difficulty of differentiation from adenoid cystic carcinoma on aspiration biopsy.

Two cases of basal-cell adenoma (basaloid monomorphic adenoma, dermal analogue tumor) seen in a one-year period were subjected to fine needle aspiration biopsy and subsequent histologic confirmation. Two cases of adenoid cystic carcinoma occurring in the parotid region were selected for comparison; a great similarity between the two types of tumors was noted. On aspiration smear both lesions consisted of clusters and sheets of uniform, small, regular cells with scant basophilic cytoplasm and regular round or oval bland nuclei. The smears contained varying amounts of homogeneous, pale, eosinophilic stromal substance within and around the cell clusters. Individual cell differences between the two lesions were minimal, with the adenoid cystic carcinomas tending to exhibit more nuclear hyperchromatism and irregularity; the architectural arrangements of the cell clusters and the stromal substance permitted differentiation between the two lesions.

Adenoma↗
PubMedDate not supplied

Characterization of human malignant melanoma cell lines. IV. Cytologic and histochemical characteristics.

The cytologic and histochemical characteristics of seven established human melanoma cell lines were studied using monolayer culture and cytocentrifuge perparations. The morphology of the cells is different in the two preparations. There is a strong resemblance between the Cytocentrifuge preparations and the histological tissue sections and cytologic smears that are used in routine diagnostic work.

Cell Line↗
PubMedDate not supplied

Fine needle aspiration biopsy cytology of paragangliomas. Cytologic, light microscopic and ultrastructural studies of three cases.

Paragangliomas are uncommon tumors arising in paraganglion tissue, which is especially well represented in the head and neck. In our hospital three head and neck masses recently proved to be paragangliomas on aspiratory biopsy cytology, with subsequent histologic confirmation. One was an apparently benign carotid body tumor, while the others were metastatic nasopharyngeal paragangliomas. The latter two tumors were clearly malignant, with roentgenographically proven pulmonary metastases in one and widespread lymph node involvement in the other. Histologically all were vascular tumors composed of large cells with abundant cytoplasm and pleomorphic, sometimes bizarre nuclei. These characteristic chief cells were clearly evident on cytology, with pleomorphic nuclei, prominent nucleoli, clumped chromatin and generally eosinophilic, finely granular or reticular cytoplasm. However, the distinction between benign and malignant tumors depended on the presence of mitoses or a tumor diathesis. Cytology seems to be able to provide a diagnosis of paraganglioma and, in these cases at least, an estimation of the biologic behavior.

Biopsy, Needle↗
PubMedDate not supplied

Needle aspiration cytology of a benign and a malignant schwannoma.

The histologic and cytologic features of an uncommon solitary, malignant schwannoma and a benign schwannoma are presented. The benign tumor revealed characteristic interlacing fascicles of spindle-shaped cells on both histology and cytology. The malignant schwannoma produced a variable histologic pattern that was selectively sampled from a recurrence in a scar; only obviously malignant, undifferentiated, spindle-shaped cells not capable of further characterization were seen on cytology. Preliminary experience with immunoperoxidase staining for the neural crest marker S-100 protein has been encouraging and may permit identification of these tumors on aspiration smears.

Aged↗
PubMedDate not supplied

Needle aspiration cytology of sebaceous carcinoma.

Sebaceous carcinoma is uncommon and usually presents in the ocular adnexae as cancer of the meibomian glands. That cutaneous sebaceous carcinoma generally occurs along with other epidermal elements has caused some nosologic confusion; tumors in which sebaceous elements predominate are encountered rarely. They are aggressive tumors in any location but particularly around the ocular adnexae, necessitating wide excision and careful follow-up to detect metastases. At our institution two such tumors were excised recently, one from the eyelid and one from previously irradiated skin. Subsequent metastases were detected without difficulty on needle aspiration cytology, which produced characteristic epithelial cells with bubbly , lipid-rich cytoplasm. The cytologic, histologic and ultrastructural appearances of these tumors that are suited to diagnosis on fine needle aspirates are reported.

Adenocarcinoma↗
PubMedDate not supplied

Endoscopic brush cytology and biopsy in the diagnosis of cancer of the upper gastrointestinal tract.

Brush cytology and biopsy under direct vision was performed on 250 patients. Of the 44 proven cases with cancers of the upper gastrointestinal tract, brush cytology yielded positive results in 88.6%, and multiple mucosal biopsies yielded positive results in 93.2%. With the combined technique the results increased to 95.4%. False-negative results were due to large tumors with necrotic surfaces or to infiltrative tumors at the cardioesophageal junction. There was one false positive with brush cytology and none with biopsy. Four cases of early gastric cancer were diagnosed with the combined technique.

Biopsy↗