Biomedical subjects

A H Subratty

Publications and source records attributed to A H Subratty.

24 records · Page 2Linked to original sources

PubMed1995

Major inhalant allergens in Mauritius.

BACKGROUND: Bronchial asthma appears to be an important but neglected problem in tropical countries. There is little information about the role of atopy in tropical climates and how atopy is related to asthma there. OBJECTIVE: The present work was aimed at determining the pattern of total serum IgE-titers among a group of patients suffering from asthma in Mauritius. METHOD: Twenty-five asthmatic patients and ten controls who met the criteria for the study were registered. A comprehensive clinical evaluation was followed by allergy skin testing (prick test) to common aeroallergens. Serum total IgE levels were measured in all 35 participants. RESULTS: Of 22 patients studied, 22 had significant levels of IgE when tested to airborne allergens. Positive skin tests against Dermatophagoide pteronyssinus and Dermatophagoide farinae correlated well with the presence of serum total IgE. Sixteen patients also had had moderate to severe exacerbations throughout the year. CONCLUSIONS: The results suggest that house dust mite is an important allergen producing symptoms throughout the year in our patients.

Administration, Inhalation↗

PubMed1994

TAME-esterase activity during a prolonged attack of asthma.

We measured serum N-alpha-tosyl-L-arginine methyl ester (TAME)-esterase activity in a group of patients suffering from a prolonged attack of asthma. Measurements were made pre and post salbutamol nebulization. Our results showed that TAME-esterase activity did not change significantly pre or post nebulization. Based on our experimental data, we concluded that increase serum TAME-esterase activity is a biochemical substance associated with the early asthmatic response but not with prolonged attack of asthma.

Adult↗

PubMed1994

A new visual analogue scale for assessment of dyspnoea in congestive heart failure.

A new (quality of life) visual analogue scale of dyspnoea has been designed to evaluate the severity of dyspnoea in patients with congestive heart failure (CHF). The index has 10 numerical values, rated on a scale from 0-10, each value corresponding to an intensity of breathlessness. Since dyspnoea is a primary symptom that restricts the quality of life in patients with congestive heart failure, the new scale provided a simple, easily comprehensible and inexpensive instrument to assess the severity of breathlessness. We also report the sensitivity of the visual scale of dyspnoea before and after the administration of intravenous injection of a diuretic (frusemide) in CHF patients.

Dyspnea↗

PubMed1994

Tosyl arginine methyl ester induces bronchoconstriction in rabbit bronchial tissues in vitro: a possible new mediator in asthma.

Tosyl arginine methyl ester induced bronchoconstriction in rabbit bronchial rings mounted in vitro with a calculated EC50 of 5.6 x 10(-5) M as compared with acetylcholine which induced sustainable constriction with an EC50 of 2.5 x 10(-6) M. Tosyl arginine methyl ester, however, had definite bronchoconstricting properties though less potent than acetylcholine. We concluded that our data support the hypothesis that tosyl arginine methyl ester could be a possible biochemical mediator of airway contraction.

Acetylcholine↗

PubMed1993

Increased blood [TAME]-esterase activity during exercise-induced asthma.

Twelve non-atopic asthmatic children who were reported to be suffering from exercise-induced asthma (E-IA), and eight non-asthmatic children, were studied in an attempt to discern possible associations between N-alpha-tosyl-L-arginine methyl ester [TAME]-esterase activity and E-IA, and the late asthmatic responses. Lung function tests and clinical examinations were performed at rest, and immediately and four hours after cycling for 6 min. Concomitant blood investigations revealed a consistent elevation in the asthmatics of [TAME]-esterase activity and peripheral blood eosinophil levels, immediately following exercise. Our findings suggest that E-IA is associated with a certain threshold of [TAME]-esterase activity as measured by a simple and a rapid colorimetric method.

Adolescent↗

PubMedDate not supplied

Role of circulating inflammatory cytokines in patients during an acute attack of bronchial asthma.

Experimental studies show the unique aspects of cytokines profiles in various inflammatory diseases of the lung lead to different clinical manifestations. To elucidate the potential role of cytokines in the pathogenesis of bronchial asthma, plasma interleukins-1 beta, interleukin-6, interferon-gamma and tumour necrosis factor-alpha were measured in 32 asthmatics during an onset of acute asthma. Nine healthy volunteers were included as controls. Cytokine levels were measured by using commercially available ELISA kits. Our results showed that except for interleukin-6, increased concentrations of cytokines were not detected in the controls. Detectable concentrations of IL-6 and TNF-alpha were more common in patients than in controls. However, Interferon-gamma concentrations were below the threshold of detection in both patient and control groups. In conclusions, our results suggest that IL-6 and TNF-alpha are involved during the onset of an acute attack of asthma once the threshold limit has been passed. Hence, these two cytokines are important markers of the inflammatory components of acute asthma.

Acute Disease↗