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Biomedical subjects

A Häger

Publications and source records attributed to A Häger.

28 records · Page 2Linked to original sources
PubMed1978

Adipose tissue cellularity in obese school girls before and after dietary treatment.

Mean fat cell size and adipose tissue cellularity were studied in 18 grossly obese girls and 17 age-matched reference girls. The obese girls had a combined hypertrophic-hyperplastic obesity with increments in fat cell size as well as in fat cell number. High insulin levels were found in the obese girls and the levels correlated with fat cell size. The obese girls had higher serum triglyceride levels than the reference group but the cholesterol levels were similar. After dietary treatment and advice for increased physical activity of the obese group, both groups were re-investigated with respect to adipose tissue cellularity after 1.5 to 1.9 years. Fat cell number was unchanged in the reference group while the obese girls in spite of treatment increased their cell number significantly. The obese girls who were most successfully treated had the lowest increase in fat cell number. The results suggest that treatment of childhood obesity may be of importance for the prevention of obesity later in life.

Adipose Tissue↗
PubMed1978

Glucose-containing oligosaccharides in the urine of patients with glycogen storage disease type II and type III.

Patients with glycogen storage disease type II and type III were recently found to excrete increased amounts of a glucose-containing tetrasaccharide DGlcp(alpha1 leads to 6)DGlcp(alpha1 leads to 4)DGlcp(alpha1 leads to 4)DGlc [Lennartson, G., Lundblad, A., Sjöblad, S., Svensson, S. and Ockerman, P.A. (1976) Biomed. Mass Spectrom. 3, 51--54]. In addition to this tetrasaccharide, urine from these patients also contains larger oligosaccharides containing only glucose. From urine of patients with glycogen storage disease type II and type III, three and four oligosaccharides respectively have been isolated. Structural studies including sugar analyses, methylation analyses, partial acid hydrolysis and optical rotation revealed that three compounds were present in the urine of both patients. Their proposed structures or partial structures are as follows: DGlcp(alpha1--6)DGlcp(alpha1--6)DGlcp(alpha1--4)DGlcp(alpha1--4)DGlcp(alpha1--4)DGlc, DGlcp(alpha1--4)DGlcp(alpha1--6)DGlcp(alpha1--6)DGlcp(alpha1--4)DGlcp(alpha1--4)DGlc, and DGlcp(alpha1--6)DGlcp(alpha1--4)DGlcp(alpha1--4)DGlcp(alpha1--4)DGlcp(alpha1--6)DGlcp(alpha1--4)DGlcp(alpha1--4)DGlc. A fourth compound has been partially characterized as a branched heptasaccharide with four (1 leads to 4) linkages and two (1 lead to 6) linkages. Glycogen is possibly the origin of these compounds. However, the number of (1 leads to 6) linkages is higher than expected and may indicate a shorter distance between branches in glycogen than has been generally assumed.

Child↗
PubMed1977

Body fat and adipose tissue cellularity in infants: a longitudinal study.

Body fat, fat cell size, and fat cell number were determined in a longitudinal study on 16 normal-weight infants during the age period 1-18 mo. The methods used included whole-body counting of 40K for determination of body fat and adipose tissue biopsies. A new method of calculation of body fat in infants is presented. No sex differences were found. Body fat expressed as per cent of body weight increased from 16.2% to 28.1%. From 1 to 12 mo of age the expansion of body fat was explained by and increase in fat cell size, while in the age period 12-18 mo it was mainly due to an increase in fat cell number. At 18 mo lthe fat cell size was the same as in 8-yr-old girls and 22-yr-old women (normal-weight females previously studied). The fat cell number at 18 mo, however, was far below the number at 8 yr of age, as well as the still higher number of the 22-yr-old women.

Adipose Tissue↗
PubMed1977

Effect of age on human adipose tissue metabolism and hormonal responsiveness.

The effects of age and fat cell size on the metabolism of white human adipose tissue were analysed independently. Abdominal subcutaneous adipose tissue specimens were obtained from children varying in age from 0-15 years and from adults (mean age +/- S.D.; 38.2 +/- 14.1 years). The basal rates of lipolysis and glucose incorporation into lipids were considerably higher in children than in adults even when differences in fat cell size had been taken into account. Lipolysis in response to a maximal concentration of noradrenalin was higher in fat cells from children. However, on a percentage basis the responsiveness to this agent was similar in children and adults. Irrespective of age, glucagon did not elicit a lipolytic response. Thus, it does not seem that the increased lipolysis known to occur in vivo in the neonatal period is due to a direct effect of glucagon on white adipose tissue. However, the overall lipolytic capacity is increased in fat cells from children.

Adipose Tissue↗
PubMed1977

Asymptomatic diabetes in childhood and adolescence. A review.

An account is given of the present conception of asymptomatic (chemical) diabetes in the pediatric age group, which also has been named MODY (maturity-onset type of diabetes of young people). Long-term studies show that about 10% will eventually decompensate to overt diabetes. In contrast to classical juvenile-onset type of diabetes the inheritance of MODY seems to be autosomal dominant in many cases. Some authors have suggested that insulin resistance exists in non-obese patients with asymptomatic diabetes, but this view is not supported by observations of the author. Obese patients should reduce their body fat, but other therapeutic approaches are difficult to evaluate because of the normal fluctuation of the disease. There is no general agreement in the literature concerning the value of insulin treatment. The author supports the view that insulin treatment should be started in the late stages of chemical diabetes just before symptomatic disease emerges. In the long run this approach may ameliorate the condition due to the preservation of some beta-cell function for long periods. An unsettled question is whether early insulin treatment in asymptomatic diabetes will delay diabetic vascular complications.

Adolescent↗
PubMed1975

Absence of insulin resistance in 4 cases of mild juvenile diabetes. A preliminary report.

Four children with a mild non-insulin-requiring diabetes were studied. They had no insulin response at intravenous glucose tolerance test. When insulin was infused at a rate which simulated a normal early insulin response to intravenous glucose, blood glucose decreased to the same extent as it did in healthy subjects. When a normal early insulin response was simulated during the intravenous glucose tolerance test, the glucose assimilation rate was normalized. These results suggests that a peripheral resistance to insulin is unlikely in mild juvenile diabetes, and that the primary defect is a deficient release of insulin.

Adolescent↗