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Biomedical subjects

A Høegholm

Publications and source records attributed to A Høegholm.

At least 37 records · Page 2Linked to original sources
PubMed1992

White coat hypertension diagnosed by 24-h ambulatory monitoring. Examination of 159 newly diagnosed hypertensive patients.

The study was conducted to estimate the frequency of white coat hypertension, ie, hypertension when in contact with the doctor only, in patients with newly diagnosed hypertension. We studied 159 consecutive patients (median age 47 years, 86 women) referred from primary health care to a hypertension clinic. For all patients, their general practitioner had decided to treat the hypertension pharmacologically, but the treatment had not yet begun. The blood pressure measurements reported from the referring doctors were 164.1 +/- 18.1/104.3 +/- 7.1 mm Hg (mean +/- SD). Measured at the hypertension clinic with random zero sphygmomanometer the pressures were 156.8 +/- 22.5/99.8 +/- 11.7 mm Hg. The indirectly measured day-time ambulatory blood pressures were 145.2 +/- 18.1/95.9 +/- 11.5 mm Hg. When a cut-off level of 90 mm Hg diastolic was applied, all patients were considered hypertensive by the referring doctors' measurements; the random zero office measurements regarded 18.3% of the patients as normotensive. The ambulatory measurements regarded a further 24.8% as normotensive (white coat hypertensive), whereas five patients considered normotensive by office measurements were hypertensive when evaluated by ambulatory monitoring (reverse white coat phenomenon). The difference between systolic office measurements and the daytime ambulatory blood pressures was significantly larger for female patients; age was positively correlated and weight negatively correlated to this difference. No significant difference was found for the diastolic measurements. It is concluded that white coat hypertension is present in approximately a quarter of the patients with newly diagnosed hypertension. By implementing ambulatory monitoring in clinical practice some of the overdiagnosing will possibly be avoided, but further studies on the subject are needed.

Adolescent↗
PubMed1992

Clinical evaluation of the Takeda Medical (A & D) TM 2420 ambulatory blood pressure monitor. Practical experience and comparison with direct and indirect measurements.

Takeda Medical (A & D) TM 2420 is an automatic ambulatory blood pressure monitoring system employing the auscultatory technique. The device was used under stable conditions and compared to readings from the Hawksley random-zero sphygmomanometer using a double headset stethoscope and a Y-connection. We tested 85 subjects (aged 13-89 years, systolic blood pressure 85-212 mmHg, diastolic blood pressure 40-116 mmHg) and found a difference amounting to 1.6 +/- 6.7 mmHg (mean +/- SD) for systolic and 2.1 +/- 4.5 mmHg for diastolic readings (Hawksley-TM 2420). In 62 subjects a comparison with simultaneous measurement on the opposite arm with the Hawksley manometer showed similar results. When comparing intra-arterial readings from 10 subjects, a difference (intra-arterial-TM 2420) of -1.9 +/- 12.1 mmHg was found for systolic pressures, while the diastolic difference was -10.7 +/- 8.7 mmHg. Twenty-four hour monitoring was performed on 80 subjects; 70 of these yielded usable tracings. The proportion of successful recordings was acceptable, but the device was not suitable for bicycle stress testing. The quality of the accessories provided with the equipment could be improved, but in spite of this the monitoring system was found to be recommendable for clinical use.

Adolescent↗
PubMed1991

[The new ambulatory non-invasive 24-hour blood pressure monitoring system, Takeda Medical TM 2420. Reliability and practical experiences].

Takeda TM 2420 is an automatic ambulant device for measuring blood pressure which functions by auscultation of the Korokoff sounds. During static conditions, the apparatus was investigated by means of a double stetoscope and a connecting branch with the Hawksley random zero manometer. Where 69 persons were concerned (ages 13-89 years, systolic blood pressures 85-212 mmHg, diastolic blood pressure 44-110 mmHg) a difference in the systolic blood pressure of 1.5 +/- 9.2 mm Hg were found (average +/- standard deviation) and where the diastolic blood pressure was concerned 2.8 +/- 6.3 mm Hg. Statistical comparison with the Hawksley manometer on the contralateral arm in 51 volunteers produced corresponding results. In 24-hour monitoring of 80 persons, useful results were obtained in 74. The proportion of erroneous measurements was acceptable but the apparatus was unsuitable for exercise testing on an ergometer bicycle. The quality of the cuff, the connecting tubing, the carrying strap and computer programmel should be improved but the apparatus was otherwise found to be useful for daily clinical use.

Adolescent↗
PubMed1989

[The time interval before hospitalization in acute myocardial infarction].

The prehospital time interval in 103 patients with acute myocardial infarction was investigated. Twenty patients were admitted with cardiac arrest. In the remaining patients the average total delay was found to be 3.3 hours and the patient delay 1.5 hours. The total delay was significantly prolonged in patients who were admitted during working hours, patients who were unaffected on admission, patients transported for long distances, patients who had been visited by their doctors prior to admission and patients who contacted their own doctors. The authors find that attempts should be made to reduce these delays by means of information both to the public and to doctors.

Denmark↗
PubMed1989

[Heart-lung transplantation].

To date, more than 200 human heart-lung transplantations (HLT) have been performed in USA and Europe. The main indications are still primary pulmonary hypertension and Eisenmenger's syndrome but the intervention has also been employed in cases of parenchymatous pulmonary disease. At operation, the thoracic organ is replaced. The recipient's heart can frequently be donated. Recent reviews suggest acceptable two-year survival following HLT of approximately 60%. The direct economical costs of transplantation have been stated to be approximately 17,000 pounds but to this must be added the expenses for life-long immunosuppressive treatment and follow up control together with hospitalization during the time waiting for a suitable donor. The annual requirement for transplantation in Denmark is estimated at present to be approximately ten patients. The immediate requirement for transplantation will probably be covered by referral to the European centres via national or provincial hospitals and with the permission of the Danish Board of Health. The case reports of the first two Danes (both with emphysema secondary to alpha-1-antitrypsin deficiency) who underwent successful heart-lung transplantations in England are presented. In the long run, it will prove necessary to utilize Danish donors which necessitates alterations in the criteria of death.

Adult↗
PubMed1989

Bartter's syndrome--treatment with potassium, spironolactone and ACE-inhibitor.

The treatment of Bartter's syndrome is fraught with difficulties, and there is no consensus concerning the pathogenetic mechanisms involved. Potassium depletion with hypokaliaemia is a dominant feature of the syndrome. In this case history, a 42-year-old woman suffering from Bartter's syndrome did not improve on several therapeutic trials. An impressive progress was noted, however, after intensive potassium repletion with subsequent potassium/spironolactone/ACE-inhibitor treatment. After 24 months her condition was unchanged with normal and stable Se-potassium concentration.

Adult↗
PubMed1989

Benzodiazepine antagonism by aminophylline.

A double-blind, randomised study was performed to investigate whether aminophylline could reverse the sedative effect of benzodiazepine and if it could shorten the observation time necessary after benzodiazepine sedation. Forty patients undergoing minor abdominal, urogenital or lower extremity surgery were given benzodiazepine to maintain a state of deep sedation after spinal or epidural analgesia was achieved. Postoperatively, the patients received either aminophylline, 110 mg, or physiological saline intravenously. The aminophylline-treated patients showed a significantly more rapid reversal of sedation, but after 30 min there was no difference between the two groups. It is concluded that aminophylline antagonizes the sedative effect of benzodiazepine, but in routine benzodiazepine sedation, aminophylline will not shorten the necessary observation period after sedation.

Adult↗
PubMed1988

Effect of bepridil on metabolic control and insulin secretion in diabetics.

In a double-blind cross-over study bepridil 900 mg followed by 300 mg daily for 11 days was given to 37 insulin (Type I) or non-insulin (Type II)-dependent diabetic patients. It did not modify the metabolic control of the patients as levels of glucose in blood and urine, doses of insulin and oral hypoglycaemic drugs, energy intake, and the number of hypoglycaemic attacks during therapy were unchanged. The serum concentration of C-peptide was not modified in either type of diabetic patient, and serum insulin in the Type I but not in the Type II patients was slightly higher during active drug treatment. No adverse organotoxic or arrhythmogenic effects or changes in possible atherogenic lipid fractions in serum could be demonstrated during bepridil therapy.

Adult↗
PubMed1987

Syncope due to right atrial thromboembolism: diagnostic importance of two-dimensional echocardiography.

Recurrent syncopes due to acute circulatory failure occurred in a 40-years-old female with a massive right atrial thromboembolus which was detected by two-dimensional echocardiography (2 DE), and subsequently surgically removed. 2 DE is an excellent and rapid screening technique for the patients with right sided intracardiac masses. The use of 2 DE should be considered for patients with unclear syncopes e.g. postoperatively, following deep venous thrombosis or in cases resembling "hyperventilation syndrome".

Adult↗