PubMed Health⌕ Search

Biomedical subjects

A Høiseth

Publications and source records attributed to A Høiseth.

At least 55 records · Page 3Linked to original sources
PubMed1988

Some aspects of antioxidant status in blood from alcoholics.

The effect of ethanol consumption on serum concentration of alpha-tocopherol, erythrocyte activities of superoxide dismutase, glutathione peroxidase, and catalase were studied in 34 male alcoholics and 35 age-matched controls. Serum concentration of alpha-tocopherol was 30% lower in the alcoholics as compared to the controls (p less than 0.001). No significant difference was found in erythrocyte activities of Cu-Zn-containing superoxide dismutase, glutathione peroxidase, or catalase between the groups. Of the 12 alcoholics with subnormal serum alpha-tocopherol, 50% had concomitant neurological clinical scores and cerebellar atrophy, and their neurological scores were significantly higher (82%) than for alcoholics with normal alpha-tocopherol levels (p less than 0.03). However, no significant correlation was observed between levels of alpha-tocopherol and neurological clinical scores or cerebellar atrophy. When entering the study, alcoholics and controls were each randomized into two separate groups, receiving vitamin E supplementation (100 mg/day) or placebo capsules for 10 days, respectively. In the four subgroups, alpha-tocopherol levels increased only in alcoholics receiving vitamin E supplementation (23%) (p less than 0.001). The reduced serum levels of alpha-tocopherol in alcoholics may be normalized by vitamin E supplementation.

Adult↗
PubMed1988

Femoral bone density measurements by single energy computed tomography related to hip fractures.

We measured bone density in various parts of the femur by using single energy quantitative computed tomography. In the cadaver studies we found significant correlations between the trabecular and cortical bone density and the structural strength of the femur in bending and rotational loading. This was observed in parts of the femur distant from the fracture site in the femoral neck. Good reproducibility of the density measurements was obtained at the condylar level, a site easily accessible for clinical measurements. In a clinical study, we could record post-traumatic osteoporotic changes at 5% precision level.

Absorptiometry, Photon↗
PubMed1988

Bone mineral content and mechanical strength. An ex vivo study on human femora at autopsy.

Bone mineral content as determined by computed tomography (CT) and mechanical strength on axial loading were compared in 36 cadaveric femur specimens. In axial loading, 34 femora fractured vertically in the neck, one femur fractured subtrochanterically, and one in the shaft. Based on the CT measurements of density and area, the mass of a transverse slice of the femur was estimated. Highly significant correlations were demonstrated between strength and cancellous bone density. Even higher correlations were revealed when the bone masses of the proximal and distal femoral areas were calculated. Based on these findings, an equal distribution of the effective mass of the femur was postulated.

Adult↗
PubMed1987

Strength of femoral neck fracture fixation. Comparison of six techniques in cadavers.

A neck osteotomy parallel to the femoral shaft was made on 36 cadaveric femora using the contralateral intact femur as a control. The osteotomies were fixed using a Thornton nail, two von Bahr screws, three Gouffon screws, three Knowles pins, a Haukebø compression screw, or an AO compression screw. The femora were then tested for bending strength using the load ratio test/control at 2- and 5-mm displacement as an expression of the relative strength of the osteosynthesis. There was no difference between the von Bahr, Haukebø, and the AO screws. These implants gave stronger fixation than the Thornton nail, Gouffon screws, and Knowles pins. The Thornton nail was stronger than three Gouffon screws or Knowles pins. The relatively stronger compression hip screws were thus not superior to two optimally placed 5-mm screws.

Aged↗
PubMed1983

Comparison of iohexol and meglumine-Na-Ca metrizoate in visceral angiography.

Visceral angiography was performed in a double blind study in 54 patients using iohexol (350 mg I/ml) and meglumine-Na-Ca metrizoate (370 mg I/ml). No significant increase in serum values of either hepatic or pancreatic enzymes or electrolytes was registered. Both contrast media gave excellent demonstration of arteries as well as veins. Iohexol gave far less sensation of heat during the injections than metrizoate.

Adult↗
PubMed1982

Femoral neck angles: a specimen study with special regard to bilateral differences.

The femoral neck angles were determined in 48 pairs of normal specimens from cadavers of elderly Norwegians, 24 males and 24 females. The anteversion angle was found to average 10.4 degrees +/- 6.7 degrees and the neck-shaft 127.7 degrees +/- 7.6 degrees. There were no significant differences between the sexes. The bilateral differences were analysed. The 95 per cent confidence limits of the anteversion and head-neck-shaft angles were calculated to be 11.8 and 13.8 degrees, respectively.

Aged↗
PubMed1982

Femoral neck angles in osteoarthritis of the hip.

Femoral neck angles were determined in 44 patients with unilateral or bilateral idiopathic osteoarthritis of the hip. The mean anteversion angle was 20 degrees +/- 9 degrees and the neck-shaft angle 131 degrees +/- 7 degrees. In comparison with a normal material the anteversion was significantly larger in the patients (P less than 0.001), but no difference was found in the neck-shaft angle. A positive correlation between the size of the anteversion and the severity of the disease was observed. It is concluded that increased anteversion of the femoral neck may contribute to the development of osteoarthritis of the hip.

Aged↗
PubMed1982

Streptokinase of heparin in the treatment of deep vein thrombosis. Follow-up results of a prospective study.

In a previous study on 42 patients with acute deep vein thrombosis, randomly allocated to treatment with streptokinase or heparin, we found that 71.4% of the streptokinase-treated patients achieved phlebographically significant thrombolysis as compared to 23.8% in the heparin group. These patients have been reevaluated after a mean observation period of 6 1/2 years. Seven patients had died and there were no other drop-outs. Thus, 35 patients were subjected to the follow-up study consisting of phlebography and clinical examination. The evaluations were performed without knowledge of the initial therapy. Seven patients had phlebographically normal veins, and all belonged to the streptokinase group. This difference between the treatment groups is statistically highly significant (p less than 0.01). At clinical examination, 13 of the 17 patients in the streptokinase group had normal legs and 4 exhibited moderate postthrombotic changes. In contrast, 3 of the heparin-treated patients showed serious postthrombotic changes with open leg ulcers, and only 6 of 18 patients in this group had normal legs. The present results strongly support the assumption that streptokinase therapy is the best treatment at present in patients with acute deep vein thrombosis. This has been shown for the initial thrombolysis, and now also for the avoidance of late postthrombotic changes.

Adult↗
PubMed1981

Detection of mitral regurgitation by Doppler ultrasound. A comparison with left ventricular angiography.

Sixty-four patients with various heart diseases were evaluated for mitral regurgitation (MR) by left ventricular angiography and pulsed Doppler ultrasound within 2-3 days. Adequate Doppler recordings were obtained from 60 patients. The sensitivity of Doppler in detecting MR was 94%, specificity 90% and predictive value for a positive and a negative Doppler examination 90 and 93%, respectively. Two of the 3 false positive Doppler recordings were from patients with coronary heart disease, ischemic papillary muscle dysfunction may have caused MR inconsistently. Two false negative Doppler recordings may be related to problems in placing the ultrasonic sample volume at the systolic retrograde blood stream in the left atrial cavity. It is concluded that pulsed Doppler ultrasound, being a transcutaneous, non-invasive method, is a valuable tool in detecting MR. So far, we have not been able to quantitate the regurgitation.

Adolescent↗
PubMedDate not supplied

Are patients with fractures of the femoral neck more osteoporotic?

Combined cancellous/cortical density and mass in the femur and lumbar spine were assessed 2 or 3 days after femoral neck fractures and compared to identical measurements in control subjects. Cancellous density was also assessed in the spine. Correction for age differences between patients and controls were made by means of regression analyses and by selecting groups without age differences. After compensation for the age differences, the patients were found to have significantly lower femoral bone mass and lumbar density than the controls. The femoral density and lumbar mass density were not significantly different in the two groups after age correction. The findings for the cancellous spinal density was equivocal. The study indicates that in the femur the total bone mineral content is lower in patients with femur neck fractures and that it is at least one of the etiological factors of these fractures. However, in the femur it is not the bone density that is the decisive factor, but the amount of calcified bone, or the bone mass.

Age Factors↗
PubMedDate not supplied

Evaluation of the Dunlap/Rippstein method for determination of femoral neck angles.

The accuracy of the Dunlap method, as modified by Rippstein, for measuring the femoral neck angles was evaluated using adult bodies. The results were correlated to measurements on the dissected femurs. The Dunlap/Rippstein method correlated well with the determinations made in the specimens. The accuracy of the method was within +/- 7 degrees for the anteversion angle and within -5 to +9 degrees for the head-neck-shaft angle.

Autopsy↗
PubMedDate not supplied

Femoral anteversion measured by the Dunlap/Rippstein and Norman methods.

Measurements of femoral anteversion obtained with the Dunlap/Rippstein method in adults were compared with measurements using the Norman method. By definition, different angles are measured by the two methods. The Norman method gave angles for the femoral anteversion which were on average 12.8 degrees higher than those obtained with the Dunlap/Rippstein method, and the methods correlated poorly. It is concluded that measurements of femoral anteversion with these methods do not accurately reflect each other.

Adult↗
PubMedDate not supplied

Aspects of femoral neck anteversion. Theoretical considerations and experimental results.

Although the general definition of femoral neck anteversion seems to be accepted, the details vary substantially and some measuring methods are based on anatomic prerequisites that are lacking. This may be a cause of inconsistent and incorrect determinations. An anatomic study was therefore performed. Only small differences were found between two neck axes and different methods for delineating the axes. Inconsistent use of the shaft axis gave substantial variations. The long axis of the femoral shaft was, however, not shown to be a source of substantial error. The variation between three different knee axes was substantial. The cross section of the femoral neck was found to be radially asymmetric. Therefore, a precise and unequivocal neck centre cannot be made by any combination of bi-plane projections of the neck.

Femur Neck↗