PubMed Health⌕ Search

Biomedical subjects

A Hüls

Publications and source records attributed to A Hüls.

34 records · Page 2Linked to original sources
PubMed1984

[Conventional roentgen diagnosis and computed tomography of the temperomandibular joint in myoarthropathy].

Clinical utilization of the high resolution, thin-slice CT (slice thickness: 1 mm) makes it possible to systemize the bony structure changes of the joint correlated with disfunctions. Using this technique total evaluations of this complex can be made. In patients suffering from myoarthropathy, the partially typical changes in both the functional anatomy, as well as in form, structure and topography of specific regions of the joint can be viewed objectively. The alteration process of the temporomandibular joint is considered causal in connection with muscular disfunctions, which often lay the foundation for chronic pain conditions in the regions of the face and head. The broad spectrum of conventional radiographic techniques documents, on one hand, the extremely unfavorable anatomy of the temporomandibular joint with regard to radiography. On the other hand, it also implies a certain amount of diagnostic uncertainty in this region. Comment is made concerning the informational value as well as the limits of the most important radiologic techniques. It is of utmost importance to evaluate the radiographic findings of the temporomandibular joint in myoarthropathies with a clinical functional analysis, which is easy to carry out.

Humans↗
PubMedDate not supplied

Novel histamine H3-receptor antagonists with benzyl ether structure or related moieties: synthesis and structure-activity relationships.

In search of new histamine H3-receptor ligands sixteen ether derivatives of 3-(1H-imidazol-4-yl)propanol with benzylic partial structure or related moieties were prepared and investigated as H3-receptor antagonists. The new compounds belong to a general construction pattern developed by other histamine H3-receptor antagonists. Structural modifications were introduced in an attempt to optimize in vitro as well as in vivo activity. Structure-activity relationships of the new histamine H3-receptor antagonists are discussed. All ether derivatives showed in vitro activities in the nanomolar concentration range, but only compounds with bulky lipophilic residues were also active under in vivo conditions. The most active compound within this series was 3-(1H-imidazol-4-yl)propyl 1-naphthylmethyl ether (4n) presenting an ED50 of 3.2 +/- 1.9 mg/kg regarding enhancement of endogenous histamine in brain after p.o. administration to mice. Furthermore, comparison of the H3-receptor activities measured on synaptosomes of rat cerebral cortex and on guinea pig ileum gave a good correlation indicating homogeneity of central and peripheral H3-receptor test models. The most interesting compounds were also evaluated in functional in vitro assays with regard to their activities at histamine H1-, H2-, and muscarinic M3-receptors. The tested compounds showed very weak activities at these receptor subtypes demonstrating their H3-receptor selectivity.

Animals↗
PubMedDate not supplied

Marginal accuracy and fracture strength of conventional and copy-milled all-ceramic crowns.

In this comparative in vitro study, the marginal accuracy and fracture strength of conventional and copy-milled In-Ceram crowns were examined. Anterior crowns with medians of 32.5 microns for the conventional technique and 38 microns for the copy-milled units had significantly smaller gaps than premolar crowns that had a median marginal gap of 45 microns for both techniques. There was a significant difference in fracture strength only for anterior crowns. The study indicates that copy-milled In-Ceram crown have clinically acceptable margins and fracture strength and reduce laboratory fabrication time.

Aluminum Oxide↗