MTT assay for drug resistance in childhood acute leukemia and effect of cyclosporin and interferon. A preliminary report.
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Antineoplastic Agents↗
Biomedical subjects
A Hacibektaşoğlu
Publications and source records attributed to A Hacibektaşoğlu.
Antisperm antibody and Klinefelter syndrome: does autoimmunity play a role in the pathogenesis?
Serum samples from 18 patients with Klinefelter syndrome (age range 20-22 years) and from a control group of 18 age-matched healthy subjects were analyzed for antisperm antibodies by a noncompetitive enzyme-linked immunosorbent assay. The antisperm antibody values were found higher in 5 patients (27.7%) than the level of 150 mU/100 microliters which was considered the upper level of the normal range (p < 0.01).
Adult↗
[Relationship of histocompatibility groups to chronic HBV infections].
HLA-A, B, C and DR locus specificities studied in 168 patients (71 Chronic active Hepatitis, 97 Chronic Persistent Hepatitis) serologically and histopathologically proven Chronic Hepatitis B Virus infection. There were 113 men and 55 women with a mean age of 23.2 (21-52) years. Hundred and seventy four healthy subjects (107 men, 67 women) included in control group with a mean age of 26.4 (20-54) years. The frequency of HLA A3 (p < 0.01), HLA A11 (p < 0.01), HLA B35 (p < 0.05) and HLA B51 (p < 0.01) were significantly higher in patients than in healthy control subjects. Comparisons among the other HLA-A, B, C and DR locus were found to be statistically non-significant.
Adult↗
[Nose and throat carriage in "food handlers"].
From December 1991 to February 1992, 450 personnel have been investigated for pathogen microorganisms in their nose and throat. The study was performed in the Infectious Diseases Section of Gülhane Military Medical Academy. Pathogen microorganisms have been isolated from 54 nose culture (12%) and 6 throat culture (1.33%). In one person pathogen microorganisms have been isolated from his nose and throat. The difference between the two groups (The nose and throat cultures) was significant at p = 0.001 by Fisher's exact test (t = 6.414). In the nose cultures the pathogen microorganisms were Staphylococcus aureus (85.2%), Proteus vulgaris (5.6%), Proteus mirabilis (3.7%), Klebsiella pneumoniae (1.8%), Citrobacter freundii (1.8%), Group C beta-hemolytic streptococcus (1.8%) and Pseudomonas aeruginosa (1.8%). Only one (1.85%) had two different pathogen microorganisms (Staphylococcus aureus and Proteus vulgaris) in his nasal culture. In the throat cultures the pathogen microorganisms were Staphylococcus aureus (66.7%) and group A beta-hemolytic Streptococcus (50%). Only one (16.6%) had two different pathogen microorganisms (S.aureus and group A beta-hemolytic Streptococcus) in his throat culture. The same pathogen microorganisms (S.aureus) has been isolated in an only one person's nasal and throat cultures (0.22%). We treated 60 personnel who were nasal and throat carriers according to the results of antibiograms. After treatment, two still had previous pathogen microorganism (Staphylococcus aureus). These two carriers were eradicated by repeating the treatment.
Bacteria↗
[Complement C3 and C4 levels in serum from acute viral hepatitis].
Serial measurements of C3 and C4 complement components were performed in 50 patients with acute, uncomplicated viral hepatitis, in the beginning of the symptoms and in the peaks of serum transaminases. There were 17 patients diagnosed as having Hepatitis A virus (HAV) infection and 33 patients diagnosed as having Hepatitis B virus (HBV) infection. There were 4 women and 46 men with a mean age of 22.1 years. In the sera of 50 healthy control subjects serum C3 and C4 complement components measured, this group was composed of 15 women and 35 men with a mean age of 26 years. The complement component levels were observed to be reduced in both viral infections, where the reduction in C3 serum concentration was found to be statistically significant but reduction in C4 serum concentration was not.
Acute Disease↗
[Incidence of hepatitis D virus infection in chronic hepatitis B virus carriers].
In carriers of HBsAg (Hepatitis B virus surface antigen) the incidence of Hepatitis D virus infection was studied in 72 (61.3%) males and 45 (38.5%) females, totally in 117 cases with a mean age of 34.8 years. There were 26 (22.2%) asymptomatic carriers of HBsAg where in other chronic carriers the diagnosis were as follows; 29 (24.7%) chronic persistent hepatitis, 20 (17.0%) chronic lobular hepatitis, 23 (19.6%) chronic active hepatitis and 19 (16.2%) posthepatic cirrhosis. The incidence of HDV serologic markers were found to be positive in 19 (16.2%) out of 117 cases.
Adult↗
[Comparison of PVRV and HDCV rabies vaccines as to immunity, reliability and protective value].
World Health Organization (WHO) recommends a new Inactivated Rabies Vaccine grown on Vero Cells, (PVRV: Purified Vero Rabies Vaccine) with the vaccine cultivated on Human Diploid Cells (HDCV: Human Diploid Cell Vaccine), for both pre and post-exposure prophylaxis. Following the widespread use of HDCV and PVRV, many comparative clinical trials have been conducted, studying the safety and predictive values of these two vaccines. In the present study, using the schedule recommended by the WHO for preexposure prophylaxis, days on 0, 7 and 21, we vaccinated 90 healthy male volunteers, age ranged between 18 and 24 (mean 20) and may expose to a risk of rabies. These 90 volunteers randomly divided into 3 different groups with 30 people in each. First group vaccinated by PVRV, 2nd by HDCV and the last group by placebo (PS) double blind. The neutralizing antibody titration was measured by Rapid Immunofluorescence Focus Inhibition Test (RFFIT) on days 0, 7, 21, 28 and 60 in Laboratories of Pasteur-Merieux, Lyon-France. On day 21, in both PVRV and HDCV group the neutralizing antibody titres have occurred and the difference was not statically significant (P less than 0.05). No serious side-effects occurred with either vaccine, although some vaccinees complained of redness, induration or local pain and exceptionally of fever, and lymphadenopathy. The geometric mean of antibody titres shows a higher titre in both PVRV and HDCV group on the 60th day of following 1st vaccination. Suggesting that a year-long protection could easily be provided with the both vaccines, till to the 1st booster dose administration.
Adult↗
[A new respiratory tract pathogen].
Chlamydia pneumoniae strain TWAR, a newly described Chlamydia organism is a common cause of pneumonia and other acute respiratory tract infections. Most TWAR infections are mild or asymptomatic, but occasionally severe pneumonia in elderly patients or with on going chronic diseases has been observed. Population antibody prevalence has shown that TWAR infection is world-wide infection and an important health problem since under-developing countries where the high rate of child death is predominant, TWAR infections cause acute respiratory tract infection in children who are less than 5 yrs of age. Re-infection during life-time emphasizes the importance of Chlamydia pneumoniae.
Antibodies, Bacterial↗