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Biomedical subjects

A Hadary

Publications and source records attributed to A Hadary.

15 recordsLinked to original sources
PubMed2005

Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease.

HER-2 overexpression, a predictive marker of tumour aggressiveness and responsiveness to therapy, occurs in 20-30% of breast cancer. Although breast cancer is a heterogeneous disease, HER-2 measurement is carried out in primary tumour. This study aims to evaluate HER-2 overexpression in primary and metastases and its effect on treatment decisions. Biopsies from primary breast cancer and corresponding metastases from 58 patients were studied. HER-2 overexpression was evaluated immunohistochemically in all primary and metastatic sites. Positive overexpression in primary and/or metastases was confirmed by fluorescence in situ hybridisation (FISH). Discordance in HER-2 overexpression between primary and metastatic sites was 14% (eight of 58 patients). Concordance was found in 50 (86%) of patients (95% CI: 77-95). In one patient (2%), HER-2 was negative in metastasis but positive in primary. In seven (12%) patients, HER-2 was positive in metastases and negative in primary (95% CI: 3.7-20), and three of them responded to trastuzumab. Gene amplification by FISH was found in all cases with HER-2 positive (+2 and +3) by immunohistochemistry. Our data suggest that a possible discordance of HER-2 overexpression between primary and metastases should be considered when making treatment decisions in patients with primary HER-2-negative tumours.

Adult↗
PubMed2002

Early detection of malignant process in benign lesions of breast tumor by measurements of changes in structuredness of cytoplasmic matrix in circulating lymphocytes (SCM test) reinduced in vitro by specific tumor antigen.

Early detection is crucial for successful treatment of all types of cancer. The specificity and sensitivity of the current methods vary from 50% to 80%. The use of specific tumor antigens and cytometric technology has resulted in the development of a new procedure for the early detection of breast tumors. This new method is reported. The test utilizes static cytometry, which records polarization and intensity changes in fluorescent light emitted from each individual lymphocyte obtained from tumor-bearing patients stimulated by the relevant specific tumor antigen. Using MUC-1/SEC as the specific antigen, we detected breast tumors with 85% specificity and 81% sensitivity in 137 breast tumor-bearing women. A significant linear correlation was found between the SCM test and the conventional classification of relative risk for breast cancer in benign lesions, suggesting that this is a precise method that could be used in mass screening for early detection of breast cancer.

Journal Article↗
PubMed2001

[Stromal tumors of gastrointestinal tract: clinical and pathological features].

During the period 1991 till 1999, ten patients with primary stromal tumors of the gastrointestinal tract (stomach, duodenum, jejunum, ileum and rectum) were treated. Nine patients underwent radical resection and one patient had non-complete resection of the tumor. The median age of the group was 63 years for 7 male and 3 female patients. The median follow-up period was 58 months. The tumor size was 4.5-17 cm. (median 10 cm.) The median survival was 43 months. Five patients remained alive without the disease (median survival 87 months). One patient died with no evidence of the disease after 12 months. One patient remains alive with liver metastases for 13 months and 4 patients died of metastatic disease (median survival 10 months). Features associated with decreased survival included tumor size > 5-8 cm., mitotic counts > 5 mitotic figures per 50 high-power microscopic fields and high cellularity.

Female↗
PubMed1995

[The milk-rejection sign and earlier detection of breast cancer].

2 cases of infants who refused to nurse from a breast with a cancerous tumor are reported. The first 6 cases of this nature were described 28 years ago. Though this sign could lead to earlier detection of breast cancer in lactating women, it has not been accepted as such by the medical profession. Had the milk-rejection sign been recognized in our cases, breast cancer could have been diagnosed months earlier. We suggest that lactating women should be asked about the nursing habits of their babies and if there is milk-rejection, the breasts should be examined with special care.

Adult↗
PubMed1994

[Intestinal obstruction due to lupin phytobezoar in a child].

Phytobezoar is a rare cause of intestinal obstruction in children. A 7-year-old boy was operated on for intestinal obstruction due to a phytobezoar. An exceptionally large amount of Lupin seeds had been eaten a few hours before the onset of pain. lupin seeds have not been documented as a cause of phytobezoar.

Bezoars↗
PubMed1987

Spontaneous perforation of the stomach in the neonate.

Three full-term female neonates developed gastric perforation during their first week of life. All three experienced severe postnatal asphyxia and improved following resuscitation. A linear perforation located in the prepyloric area was found in these patients. Direct closure was successfully performed in all three neonates. Asphyxia seems to be a major predisposing factor in neonatal gastric perforations. Focal gastric ischaemia and acid peptic activity may play part in the pathogenesis in these cases.

Female↗
PubMed1987

Wide local excision as an alternative treatment for periampullary carcinoma.

Wide excision of periampullary carcinoma is associated with low operative morbidity and mortality, but its effect on long-term survival, compared with that of pancreaticoduodenal resection, is controversial. Five patients with periampullary carcinoma were treated with wide local excision as a definitive procedure. There was no operative death, and four patients survived for two or more years following the operation. These patients are presented and the literature is reviewed.

Adenocarcinoma↗
PubMed1986

Abdominal actinomycosis.

Abdominal actinomycosis seldom occurs before puberty. The symptomatology of abdominal actinomycosis is non-specific and the diagnosis is difficult to make. Previously, this condition was associated with a high mortality rate. The following patient had a flank abscess due to actinomycosis as a late complication of perforated appendix which was diagnosed by biopsy and culture. The patient responded to a prolonged course of chemotherapy with intravenous penicillin and metronidazole. This case illustrates the problems encountered in the diagnosis and management of childhood actinomycosis.

Abscess↗
PubMed1985

Animal model for the study of internal anal sphincter activity.

This paper describes a simple and reliable model for studying the internal anal sphincter (IAS) in the rat. The activity of the sphincter was recorded by a two-balloon system. The compliance of the balloon allowed measurements of pressure changes lower than 0.1 cm H2O. The anatomical and physiological characteristics of the rat IAS were found to be in many aspects similar to those found in the human. The rectoanal reflex in the rat consists of relaxation followed by contraction. The threshold for this response is 0.4-0.6 ml of air. The response of the IAS to prolonged rectal distension showed adaptation in 50% of the animals. Intraarterial application of drugs produced rapid, dose-dependent and reproducible effects on the IAS. The results described in this work show that the rat is a useful and convenient model for studying anal function. It may be used to investigate both the physiology and pharmacology of the IAS activity.

Adaptation, Physiological↗