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Biomedical subjects

A Haile

Publications and source records attributed to A Haile.

7 recordsLinked to original sources
PubMed1997

Behçets' disease: a case report.

A 20 year old male patient presented with recurrent panuveitis associated with painful buccal and genital ulcers, subcutaneous nodules and pustules (dermatographia) on the trunk, and positive pathergy (skin hypersensitivity to needle pricks) test. Laboratory examinations were nonrevealing except for a minimal rise in ESR. This patient meets the criteria set by James and Spiteri for Beçhets' Disease. This disease and its prognosis is discussed. Early recognition and treatment of this blinding and potentially fatal disorder is emphasised.

Adult↗
PubMed1995

Hybrid and allogeneic resistance to T cell grafts mediated by murine NK and CD8+ T cells.

Lethally irradiated mice can reject H-2 allogeneic or parental strain stem cells in bone marrow cell (BMC) grafts within 48 h after transplantation. This rapid rejection of BMC grafts occurs without prior sensitization and is mediated by NK1.1+ NK cells. One hypothesis to account for the ability of host NK cells to mediate acute rejection of allogenic and parental stem cells is that these effector cells recognize hemopoietic histocompatibility (Hh-1) Ags on the donor stem cells. T cells present in the donor BMC can prevent NK cell-mediated rejection. However, lethally irradiated mice can also reject T cells present in lymph node cell preparations that respond to alloantigens of the host. T cell grafts from H-2k/Hh-1k, H-2r/Hh-1null, and H-2ia1/Hh-1null donors were rejected by CD8+ NK1.1- T cells. Ags other than Hh-1 Ags appeared to be recognized by these CD8+ T cells. In contrast, host NK cells rejected H-2d/Hh-1d T cell grafts, whereas both NK cells and CD8+ TCR-alpha beta + T cells rejected H-2b/Hh-1b T cell grafts. Therefore, both CD8+ TCR-alpha beta T cells and NK cells mediate allogeneic and hybrid resistance to T cell grafts.

Animals↗
PubMed1992

Unintended conception and unwanted fertility in Gondar, Ethiopia.

This is a report on unintended conception and unwanted fertility in Gondar, Northwestern Ethiopia. The purpose of the study was to explore the extent of the problem and to inquire whether there is a need for fertility regulation. To this end, relatively numerous questions on reproductive history of women aged 15-49 have been raised. Results showed that the proportion of abortion to delivery was 0.3984 to 0.6016 and the ratio of unintended conception to intended conception was 0.4043 to 0.5957. The proportion of unwanted fertility to wanted was 0.4099 to 0.5901. Mean desired interpregnancy interval was substantially higher than actual interpregnancy interval. The relatively high rate of abortion, high proportion of unintended conception and unwanted fertility combined with the wide difference between desired interpregnancy interval and current interpregnancy interval all point to the need for a policy that increases the capacity to regulate fertility.

Adolescent↗
PubMed1988

Clindamycin versus metronidazole in the treatment of bacterial vaginosis.

One hundred forty-three women with complaints of vaginitis were assigned to receive either 500 mg of metronidazole twice daily for 7 days or clindamycin 300 mg twice daily for 7 days. There was no significant difference in the failure rate between patients treated with clindamycin (6.1%) and those treated with metronidazole (4%). Adverse reactions were infrequent and mild in both treatment groups. Three patients who received clindamycin developed non-bloody diarrhea, which was mild and did not necessitate discontinuing therapy. We conclude that clindamycin may be a safe and effective alternative to metronidazole for treating women with bacterial vaginosis.

Adult↗
PubMedDate not supplied

Fertility conditions in Gondar, northwestern Ethiopia: an appraisal of current status.

In order to study current fertility conditions, this study examines the sociocultural, economic, and demographic characteristics of 734 women aged 15-55 in the Gondar administrative region of northwestern Ethiopia. Women over age 45 in the sample were found to have, on average, 7.27 pregnancies, 0.88 abortions, 6.39 children ever-born, 1.51 child deaths, and 4.88 live offspring. The total infertility rate was 8.5 percent, and the subfertility rate was 12.7 percent. Fertility levels in the region were relatively high, compared to other developing countries. Contraceptive use was estimated at 3.6 per 1,000 women (for ages 15-49). The need for more effective family planning services is strongly indicated. The study suggests that, among other goals, policy efforts should focus on the reduction of unintended conception and unwanted fertility.

Adolescent↗