[Magnetic resonance imaging of pituitary adenomas].
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Biomedical subjects
Publications and source records attributed to A Hakuba.
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MRI of 20 patients, 17-82 years old, with pituitary adenomas confirmed histopathologically, and 30 normal patients without pituitary dysfunction were reviewed. The studies were performed with a 0.5 Tesla MR scanner with a slice thickness of 10 mm. Inversion recovery sequences were employed as T 1-weighted examination, with repetition time (TR) of 2100-2500 msec, an inversion time (TI) of 600 msec and an echo time (TE) of 40 msec. The T 2-weighted examination had a TR of 1800-2500 msec and a TE of 120 msec. T 1-weighted images were obtained in all cases and T 2-weighted images in 14 cases. Spin echo images with a TR of 600-1000 msec and a TE of 40 msec (SE 40/600-1000) were also obtained in 14 cases. On T 1-weighted images, 20 adenomas were classified into six groups, according to their signal intensities; marked low intensity (1), low intensity (1), isointensity (11), high intensity (3), marked high intensity (1) and mixed intensity (3). On T 2-weighted images, 14 adenomas were classified into five groups; low intensity (1), isointensity (2), high intensity (4), marked high intensity (6) and mixed intensity (1). On SE 40/600-1000 images, 14 adenomas were also classified into four groups; low intensity (8), high intensity (2) and mixed intensity (3). Two adenomas with recent intratumoral hemorrhage had marked high intensity on both T1 and T2-weighted images. SE 40/600-1000 images were useful in evaluating the size and the extent of the visual pathway was best appreciated on IR images. Comparison between normal and involved cavernous sinus by adenomas was made.
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We have used scanning and transmission electron microscopy to examine adult human semicircular canals taken at autopsy and an operation. Our findings can be summarized as follows. In the semicircular circular canals obtained at autopsy from a 30-year-old male, non-sensory ciliated cells having 50-60 cilia were seen sporadically in the canal side of the ampulla of the horizontal canal. A labyrinthine specimen taken at operation demonstrated folding of the cell membrane at the base of columnar cells lining the wall of that part of the canal close to the ampulla. Distal to this site, canal wall cells became progressively flattened and their intracytoplasmic organelles were seen to be progressively less abundant. These cells were found to be layered, facing the endolymphatic space. Dense filaments and fibrocytes were present outside these cells, between which were interposed single-layered basement membranes. Since the capillary network present was found to be sparse, we believe that the portion of the canal studied does not produce endolymph but plays a role in the maintenance of the composition of endolymph and perilymph.
The authors have operated directly on four cases of intracavernous internal carotid artery aneurysms by opening the cavernous sinus. Surgery was performed using a semisitting position, in which the upper half of the patient's body was elevated approximately 20 degrees from the horizontal plane. The superior wall of the cavernous sinus was opened through the pterional approach, and an aneurysmal neck clipping was successfully performed on three patients. A coating of the aneurysm was carried out on one patient. The results obtained were excellent in all cases. The authors believe that the operative technique reported is useful for surgical treatment of intracavernous lesions.
Lesions in the parasellar region and the interpeduncular fossa, including medial-third sphenoid wing meningiomas, petroclival meningiomas, trigeminal neurinomas, and basilar tip aneurysms, are very difficult to approach for radical procedures. To minimize brain retraction and achieve excellent exposure in the shortest possible distance for safe manipulation within these regions, the authors have developed a new surgical technique, an orbitozygomatic infratemporal approach. Sixteen patients with parasellar tumors, nine patients with basilar tip aneurysms, and one patient with a P-1 distal aneurysm were operated on using this orbitozygomatic infratemporal approach, with excellent results. The operative technique and its results are detailed.
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It has been generally accepted that the direct approach to the cavernous sinus under the normal temperature is very difficult and dangerous. Bleeding from the cavernous sinus is thought to be very difficult to control. However, when the patient is kept in semi-sitting position during the operation, the venous pressure of the cavernous sinus can be decreased nearly to 0 and the cavernous sinus can be opened without any serious bleeding. Either insertion of Biobond soaked Oxycel or alternative insertion of fibrinogen soaked Gelfoam and thrombin soaked Gelfoam into the opened cavernous sinus is made to control bleeding. In the case of C-C fistula, if the cavernous portion of the carotid artery is trapped by application of temporary clips to the cervical portion of the external and internal carotid artery and the C2 portion of the internal carotid artery, one could perform the operation without any uncontrollable serious bleeding in the same manner. In such cases, in order to prevent ischemia of the brain during interruption of the internal carotid flow, EC-IC bypass is indicated and performed about two weeks prior to the direct attack of the cavernous sinus. The operation consists of subfronto-pterional transsylvian approach, removal of the anterior clinoid process, removal of the superior, lateral and inferior walls of the optic foramen as far anteriorly as possible, opening of the anterior inferior cavity and the medial cavity through the medial triangle in order to isolate the C3 and C4 portions of the internal carotid artery, and then exposure of the C5 portion of the internal carotid artery via the Parkinson's triangle.
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Three cases of intrapetrous neurinomas of the facial nerve are reported and their diagnostic and surgical problems are discussed. Two of them revealed rare intracranial extensions and the other was a typical intrapetrous expansion of the tumor. The literature of intracranial neurinomas of the facial nerve is reviewed in detail.
Our experience with the transpetrosal-transtentorial approach to retrochiasmatic craniopharyngiomas is herein reviewed and an operative technique is described. Excellent exposure of the retrochiasmatic and suprasellar regions is gained with a minimal retraction of the temporal lobe and cerebellum. Eight cases of retrochiasmatic craniopharyngiomas that extended into the posterior hypothalamus were operated on utilizing this approach. The operative results were excellent in five patients, good in one, and poor in one. There was one death later. The principal advantage of this technique is that it allows the hypothalamus, even in cases in which the structure is remarkably displaced upwards, the third ventricular walls in cases of the intraventricular extension of the tumor, and the inferior surface of the optic chiasma and nerves to be visualized directly and thus safely preserved.