Biomedical subjects

A Halse

Publications and source records attributed to A Halse.

At least 19 recordsLinked to original sources

PubMed2004

Nonsurgically retreated root filled teeth--radiographic findings after 20-27 years.

AIM: To identify periapical changes in nonsurgically retreated root-filled teeth 20-27 years after root canal treatment. METHODOLOGY: From an original material of 429 roots, retreated by undergraduate students in a teaching clinic, 112 roots in 70 individuals could be evaluated radiographically 20-27 years after treatment. The same roots had been studied 10-17 years earlier. The periapical condition was registered and compared by three observers in two series of intraoral radiographs taken 10-17 and 20-27 years after treatment. A retrospective analysis was performed to gain information about probable endodontic and nonendodontic reasons for extractions of lost roots, by evaluating their periapical status immediately after retreatment and at the 10-17-year follow-up. RESULTS: Favourable outcomes were observed in 11 roots that had radiolucencies at the 10-17-year follow-up. Eight of these roots had periapical pathosis preoperatively, five of them filled with surplus root filling material. The percentage of cases recorded as normal condition at the final follow-up was 95.5%, including five cases initially recorded with increased width of the apical periodontal space. Delayed healing as a result of surplus root filling material explained most of the cases with favourable outcome assessed many years after treatment. Twenty-eight roots were lost because of extraction during the observation period, 17 during the last 10 years. Based on status at previous follow-ups, endodontic failure seems to represent a minor reason for extraction in the material. CONCLUSION: Late periapical changes, with more successful cases, were recorded when a 10-17-year follow-up after root canal treatment was extended for another 10 years. Persistent asymptomatic periapical radiolucencies, especially those with overfill, should generally not be classified as failures, as many of them will heal after an extended observation period.

Dental Pulp Cavity↗

PubMed2004

Increased width of the apical periodontal membrane space in endodontically treated teeth may represent favourable healing.

AIM: To examine cases showing increased width of the periodontal space (IW) at a long-term follow-up examination and to determine whether this finding could be explained by endodontic or nonendodontic factors. METHODOLOGY: A series of intraoral radiographs was obtained from 131 patients 20-27 years after root canal treatment. The same individuals had been examined 10 years earlier, and radiographs taken immediately after treatment were also available. Fourteen roots (5.6%) demonstrated increased width of the apical periodontal space at the end of the study period. These were subjected to further analysis in an attempt to disclose possible explanatory factors. RESULTS: Two of the 14 cases had reduced marginal bone levels interpreted as the origin of the IW. In three cases, overextended root filling material present 10 years earlier had disappeared and the persistent IW was interpreted as representing a remodelling process. In six cases the findings were explained as being caused by physical and anatomical factors that represented healing without complete re-formation of the apical periodontal structures, or both. Three cases were judged as unfavourable, on the basis of lacking progress in healing, unsatisfactory obturation of the apical portion of the root canal or dentine resorption close to the apical end of the root filling. CONCLUSION: Most of the 14 IW cases examined after 20-27 years could be explained by reduced marginal bone support, or by physical and anatomical factors or they might represent incomplete reformation of the typical apical morphology and were thereby recorded as favourable outcomes.

Adult↗

PubMed2002

Long-term reliability and observer comparisons in the radiographic diagnosis of periapical disease.

AIM: The aim of this study was to evaluate and compare the long-term diagnostic consistency of two examiners, an endodontist and a radiologist, and to make comparisons with findings recorded by an observer with more recent scientific and clinical experience in endodontics. METHODOLOGY: Three groups, each consisting of 20 full mouth series of intraoral radiographs, with 79, 93 and 85 endodontically-treated roots, respectively, were successively evaluated for periapical disease. Evaluations were at first performed separately by the three observers. Disagreement and difficult, borderline cases were subjected to joint evaluation. Intra- and interexaminer comparisons were made. For two of the observers the observations were compared with findings recorded several years before for the same cases in the same radiographs. RESULTS: The intra- and interobserver long-term reliability of the two original examiners resulted in 83% overall agreement, the kappa values were 0.54, 0.57 and 0.53. Comparisons between all three observers disclosed 82%, 85% and 86% agreement and kappa values 0.55, 0.58 and 0.60. The joint evaluations and decisions did not indicate a dominating influence from any of the observers. CONCLUSIONS: The long-term reliability of the two original observers was judged as being satisfactory. All three observers judged the overall disease status of the material in the same way. The joint discussions of selected cases might reduce observer variation to an acceptable level, avoid a number of false recordings and increase the reliability and validity of the findings.

Humans↗

PubMed2002

Diagnosing periapical lesions--disagreement and borderline cases.

AIM: The aim of this paper is to present a selection of disagreement and borderline cases from a methodological study on the radiographic diagnosis of periapical disease. METHODOLOGY: Thirty-two roots, 12% of the material in an earlier study, were subjected to joint discussion because of diagnostic problems. The aim was consensus. Six cases representing different teeth/roots illustrating typical problems are presented. RESULTS: The varying morphology of apical areas and varying density of surrounding bone present a number of challenges. Even so, the joint discussion resulted in an agreement for all the cases. Twenty-five diagnoses were established and seven cases were not diagnosed owing to substandard radiographs. CONCLUSION: A detailed analysis of the periodontal ligament space, the lamina dura, trabecular pattern and bone marrow spaces is mandatory for the radiographic diagnosis of periapical disease

Alveolar Bone Loss↗

PubMed2002

Idiopathic osteosclerosis of the jaws followed through a period of 20-27 years.

AIM: The aim of the present study was to examine the prevalence of idiopathic osteosclerosis (IO) in a baseline sample and to follow the patients through an extended period of time. METHODOLOGY: The sample consisted of 210 patients treated in a dental school and having a complete series of intraoral radiographs at the time of treatment and at a follow-up 10-17 years later. A further 10 years later, 130 patients had another follow-up. RESULTS: Sixteen of the 210 patients were found to have IO, mostly in the mandibular molar and premolar regions. Fourteen had one lesion, one had two lesions and one had three lesions. The mean age of these patients was 47 years as compared to 44 years for the rest of the patient group. No sex predilection was found. At the first follow-up, one lesion had disappeared, one had reduced in size and one new lesion appeared. At the second follow-up, eight patients with IO could be re-examined. Two lesions, unchanged at the first follow-up, had reduced in size and two new lesions appeared. In the area of the new lesions, residual roots were observed in the earlier radiographs. CONCLUSION: Our findings support the theory that IO lesions should be considered anatomical variants. In some cases, however, a local aetiological agent may cause development of structures with an identical appearance.

Adult↗

PubMed2002

Periapical changes following root-canal treatment observed 20-27 years postoperatively.

AIM: The aim of the present study was to identify periapical changes 20-27 years after root-canal treatment. METHODOLOGY: The periapical condition of 265 roots filled by undergraduate students was evaluated in two series of intraoral radiographs taken 10-17 and 20-27 years after treatment. Roots (72) not recorded with a normal periapical situation on both occasions by two observers, were re-evaluated by other two examiners, separately and jointly. Final decisions about diagnoses were made by all four examiners. A strict definition was used for the identification of cases with an unfavourable outcome. RESULTS: Favourable outcomes were observed in 6.4% of the roots that had radiolucencies at the 10-17-year follow-up. Periapical radiolucencies after 20-27 years appeared in 1.5% of all other roots. The radiographic failure frequency for the total material was 4.9%. The percentage of cases with normal periapical findings at the final follow-up was 86.4%, whilst 8.7% were recorded with increased width of the apical periodontal space. Delayed healing owing to surplus root-filling material explained nearly all of the cases with favourable outcome assessed many years after treatment. CONCLUSIONS: Late periapical changes, with more successes than failures, were recorded when a 10-17-year follow-up period after root-canal treatment was extended for another 10 years.

Follow-Up Studies↗

PubMed1999

Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjögren's syndrome.

The aim of this study was to investigate the production of anti-Ro/SS-A antibodies in labial salivary glands (LSG) and peripheral blood (PB) of Sjögren's syndrome (SS) patients. The ELISPOT method was performed to quantify the frequency of LSG lymphocytes and PB lymphocytes spontaneously secreting anti-Ro/SS-A antibodies. The total number of IgG-, IgA- and IgM-producing cells was also quantified. The bovine Ro 60-kD protein was used as target antigen. Six of six primary SS patients had LSG B cells producing anti-bovine Ro 60 kD of the IgG isotype, and two of two primary SS patients had in addition PB lymphocytes producing anti-bovine Ro 60 kD of the IgG isotype. The six patients who had IgG antibodies against the Ro/SS-A antigen in LSG all had focus scores of >/= 7 in biopsies of LSG. The results indicate that SS patients with a high degree of local inflammation in LSG have B cells producing anti-Ro/SS-A antibodies in both LSG and PB. Thus, the anti-Ro/SS-A antibodies may have pathogenic importance in the progression of the exocrinopathy of SS.

Animals↗

PubMed1999

Ro/SS-A- and La/SS-B-reactive B lymphocytes in peripheral blood of patients with Sjögren's syndrome.

The aim of this study was to investigate the production of anti-Ro/SS-A and anti-La/SS-B antibodies in peripheral blood (PB) of patients with Sjögren's syndrome (SS). The ELISPOT method was performed to quantify the frequency of PB lymphocytes spontaneously secreting anti-Ro/SS-A and/or anti-La/SS-B antibodies. The total number of IgG-, IgA- and IgM-producing cells was also quantified. The recombinant Ro 52-kD, Ro 60-kD and La 48-kD proteins were used as target antigens. Three of 18 SS patients had PB lymphocytes secreting IgG antibodies against the recombinant Ro 52-kD protein. The same three patients had high serum titres of anti-Ro 52-kD antibodies. In addition, these patients were classified as having severe disease, and all three had focus scores of >/= 8 in biopsies of the labial salivary glands (LSG). The correlation between the number of PB cells producing IgG antibodies against the recombinant Ro 52-kD protein and the focus score was significant (P < 0.01). The results indicate that only SS patients with severe disease and high degree of local inflammation in LSG have B cells producing anti-Ro/SS-A antibodies in PB. Thus, most of the spontaneous autoantibody production must take place in other body compartments, e.g. in exocrine glands and probably also in the lymphoid organs and/or other mucosal sites.

Adult↗

PubMed1999

Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjögren's syndrome.

Sjögren's syndrome (SS) is a chronic autoimmune disease of exocrine glands. There is increasing evidence that interferon-gamma (IFN-gamma) plays a role in the pathogenesis of SS. It has also been suggested that other type 1 cytokines, as well as interleukin-6 (IL-6), IL-10 and transforming growth factor-beta, are important in the induction and/or maintenance of SS. The aim of this study was to investigate the type 1/type 2 cytokine pattern in peripheral blood of primary SS patients. The enzyme-linked immunospot (ELISPOT) assay was performed to quantify the number of mononuclear cells (MNC) secreting IFN-gamma, IL-6 and IL-10 in peripheral blood samples from 33 patients with primary SS and 12 healthy controls. The mean number of cells secreting IFN-gamma was 9/105 MNC in the SS patient group, and 4/105 MNC in the control group (P = 0.73). Fifteen of the SS patients had anti-Ro 52 kDa antibodies in serum. In this patient group the mean number of cells secreting IFN-gamma was 4/105 MNC, while in the patient group without such antibodies the mean number of cells secreting IFN-gamma was 14/105 MNC (P = 0.04). The mean number of cells secreting IL-6 was 12 000/105 MNC in the SS patient group, and 5000/105 MNC in the control group (P = 0.01). The mean number of cells secreting IL-10 was 270/105 MNC in the SS patient group, and 180/105 MNC in the control group (P = 0.04). The SS patients had a significantly higher number of cells secreting IL-6 and IL-10 in peripheral blood than the healthy controls, which may facilitate B-cell activation and production of autoantibodies.

Adult↗

PubMed1998

Stability after Le Fort I osteotomy in cleft lip and palate patients.

Le Fort I osteotomies were performed in 20 patients with cleft lip and palate as a one-segment movement, and the fragments were fixed with miniplates without bone grafting. Tracings of preoperative and serial postoperative lateral cephalograms were used to determine changes in maxillary position. The posterior nasal spine, not subjected to extensive changes during surgical procedures and remodeling, was found to be the most reliable landmark for measuring maxillary advancement and stability. The mean maxillary advancement was 5.96 mm. Analysis did not reveal significant changes in linear and angular measurements from immediately postoperative to 6 months postoperative. A modest maxillary advancement by Le Fort I osteotomy, along with alleviation of palatal scar tissue tension and miniplate fixation, is a stable surgical method in patients with cleft lip and palate.

Adolescent↗

PubMed1997

Periapical radiolucencies as evaluated by bisecting-angle and paralleling radiographic techniques.

Two groups of patients were included in the study. The first group consisted of patients who received root canal treatment of single-rooted teeth (n = 63). The completed roof fillings were exposed to two different radiographic techniques, the paralleling and the bisecting-angle technique. The second group consisted of 1-year review radiographs of patients who had received apicectomies of single-rooted teeth (n = 105). Three observers examined the radiographic images. First, they were asked to identify teeth with a normal apical condition and those with an apical radiolucency. Thereafter pairs of radiographs were compared; cases judged as normal by all observers were excluded. The observers were now asked to ascertain whether the apical radiolucency was largest in the first image, the apical radiolucency was largest in the second picture or both radiolucencies were the same size. Both intraobserver and interobserver agreement, calculated as Cohen's kappa, was high with respect to the presence of lesions within both samples and it was at the same level for both radiographic techniques. The evaluation of the size of the lesions proved to be more inconsistent. Kappa values were in the range 0.38-0.71 for intraobserver comparisons and in the range 0.25-0.48 for interobserver comparisons. No significant difference was found between the size of lesions as recorded by the two techniques (P > 0.05). It is concluded that, when correctly adjusted the bisecting-angle technique and the paralleling technique provide similar diagnostic results.

Alveolar Bone Loss↗

PubMed1996

Incomplete healing (scar tissue) after periapical surgery--radiographic findings 8 to 12 years after treatment.

Twenty-four cases treated by periapical surgery--which 2 to 6 yr after surgery were classified radiographically as incomplete healings (scar tissue)--were further followed, extending the observation period to 8 to 12 yr. One case healed completely, 1 failed, and 22 were still recorded in the same healing group. All the 22 scar tissue cases were characterized by a reduction of the defect in bone. In 13 cases, continuous periodontal structures were seen and the defect thereby separated from the root. The findings support the conclusion that cases clearly showing features of incomplete healing (scar tissue) at the regular follow-up 1 yr after surgery can be regarded as successes. They need not be recorded for further systematic control. A general follow-up program for apicectomy cases is suggested.

Apicoectomy↗

PubMed1996

Occlusal morphology in Turner syndrome.

The prevalence of malocclusion in 32 Turner syndrome patients, age 7-16.7 years, was investigated. The sample was subdivided according to karyotype, and 72 normal girls, aged 7.1-16.1 years, served as controls. Compared with normal girls overjet did not differ significantly while overbite was significantly reduced in 45X patients. The prevalence of distal molar occlusion, anterior and lateral open bite and lateral crossbite was significantly increased. Most significant differences were found between 45X patients and controls. Mosaic and isochromosome for the long arm of X karyotypes showed the same pattern of malocclusion, but with greater variation. No significant differences were found comparing 45X patients with mosaic and isochromosome for the long arm of X karyotypes. The results indicate that patients with structural and/or numerical aberration of the X chromosome, develop a specific pattern of malocclusion with deviations in sagittal, vertical and transversal directions.

Adolescent↗

PubMed1996

Craniofacial morphology in young patients with Turner syndrome.

The craniofacial morphology of 33 Turner syndrome patients, aged 7-16.7 years, was evaluated by standard cephalometric methods. The sample was subdivided according to karyotype and 72 normal girls aged 7.1-16.1 years served as controls. The size of the calvarium and face was generally smaller in the Turner group than in the controls. The morphology was characterized by a flattened cranial base angle, a marked reduction in posterior cranial base length, facial retrognathism and short and posteriorly rotated jaws. The same morphological pattern was found in all the karyotypes, but the deviations were most pronounced in monosomy X (45X) patients. The results indicate that a deviating pattern of craniofacial size and morphology has already been established in childhood. It is suggested that the deviations originate in the fetal period, when the primary cartilages form the craniofacial skeleton.

Adolescent↗

PubMed1996

Radiopacity of glass ionomer materials.

To facilitate the detection of overhangs and defects adjacent to a filling, restorative materials should have a radiographic density higher than or at least similar to that of enamel. In the present study the density of 21 glass ionomer materials was measured and compared with the density of enamel, dentine, amalgam and aluminium. Most materials were more radiopaque than enamel, thereby satisfying the requirements as proposed by several investigators. The materials with lower density were mainly types intended for use in anterior teeth where the entire filling can more easily be examined clinically. They should not be used as a base under approximal fillings in order to avoid a false positive diagnosis of recurrent caries.

Aluminum↗

PubMed1994

Detection of mineral loss in approximal enamel by subtraction radiography.

The purpose of the present study was to determine whether digital subtraction radiography will improve detectability of small, mechanically prepared defects within dental enamel. Lesions with an extent of 1 mm in vertical direction and representing 5% to 10% mineral loss in the direction of the x-ray beam were prepared in eight extracted molars. Radiographs of teeth with defects were subtracted from radiographs taken before the lesions were prepared. Seven observers evaluated the images using a five-point confidence rating scale (receiver operating characteristic technique). Examination of the original radiographs showed increasing accuracy of radiographic interpretation with increasing mineral loss as judged from the areas beneath the receiver operating characteristic curves. The same observation was made using subtraction images with and without contrast enhancement. There was no indication that subtracted images provided better diagnostic validity than the original radiographs. In conclusion, subtraction images do not seem to improve the diagnosis of well-defined lesions within dental enamel.

Dental Enamel↗

PubMed1994

Radiographic simulation of a periapical lesion comparing the paralleling and the bisecting-angle techniques.

Sixty apical areas of single-rooted teeth were examined in this study. A simulated periapical lesion was produced using an acrylic sphere (diameter 2.0 mm), the surface of which was covered with a thin layer of zinc cement. The sphere was placed in close contact with the apical foramen using a thin orthodontic wire inserted into the apical portion of the root canal. The correctly adjusted parallel projection depicted the simulated lesion with a very low degree of error. Overangulation of the central beam with maintenance of parallelism between tooth and film resulted in a moderate degree of magnification. When correctly adjusted, the bisecting-angle technique produced images with almost the same accuracy as the paralleling technique. Over-angulation resulted in most images showing a reduced size of the simulated lesion. Moderate under-angulation most often recorded the correct dimension of the globe. In some cases a magnified image of the sphere was produced. Generally, this was associated with a palatally curved root. The investigation thus clearly indicated that the paralleling technique provides the most reliable information about the extent of a pathological process.

Humans↗

PubMed1994

Root length, crown height, and root morphology in Turner syndrome.

Root length, crown height, and root morphology were studied on intraoral and panoramic radiographs in 33 Turner syndrome patients aged 7.0-16.7 years, subdivided on the basis of karyotype. Thirty-three normal girls aged 10.2-16.4 years served as controls. In the 45X patients and, with the exception of a few teeth, also in the isochromosome and mosaic karyotypes, root length and crown height of incisors, canines, and premolars were significantly reduced. Some teeth showed altered crown-root proportions. Maxillary first premolars showed a significantly increased number of two-rooted and three-rooted variants. Mandibular premolars and molars had a complex root morphology, and a classification system was established including four premolar and six molar root types. Premolars had a significantly increased number of root components. Some of the variants, such as a molar-like second premolar, are apparently specific for these patients. On several first molars a radix entomolaris was identified. Two separate mesial and one or two separate distal roots were also frequently seen. Our investigation demonstrates that X-chromosome deficiency influences root formation.

Adolescent↗