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A Hamilton

Publications and source records attributed to A Hamilton.

At least 37 records · Page 2Linked to original sources
PubMed1985

Maternal-fetal disparity at multiple minor histocompatibility loci affects the weight of the feto-placental unit in mice.

Inbred mice from selected unrelated and congenic strains were mated to determine the relative effects of maternal-fetal disparity at major histocompatibility complex (H-2) and non-H-2 minor histocompatibility antigens on the feto-placental unit at 14 days of gestation. A significant increase in weight of the feto-placental unit was observed only when mother and fetus differed at multiple minor histocompatibility loci. No increase in the weight of the feto-placental unit was observed when mother and fetus differed only at H-2. These results suggest that immunostimulation of the fetus results from a maternal response to minor histocompatibility antigens and not to H-2 antigens.

Animals↗
PubMed1985

Causal links between plasma and CSF endorphin levels in stress: vector-ARMA analysis.

To explore causal links between vital sign responses and immunoreactive beta-endorphin ("i-BE") rises in blood and CSF during ovine endotoxin stress, we analyzed concurrent i-BE levels in these two compartments by a "vector-ARMA" (= autoregressive moving average) method. This technique--widely used for modeling in other applications--has not to our knowledge been employed to study dynamic relationships of neuropeptides. Log-transformed i-BE levels were first "filtered" by repeated observations ANOVA to confirm significance of rises in both compartments. Next, vector-ARMA methodology was applied to derive an optimal causal model of vital sign changes and i-BE entry into plasma vs. CSF pools. The model indicated that reflux of i-BE from blood into CSF contributed to increases in CSF levels of this hormone. This novel application to neuroendocrinology of this approach illustrates its utility in evaluating changes in one or more neuropeptide levels in multiple compartments to indicate potentially causal relationships.

Animals↗
PubMed1979

Upper limb amputees.

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Activities of Daily Living↗
PubMed1978

Isolation of 57Co-cobalamin coenzymes at high specific activity from Streptomyces griseus.

The distribution of radio-labelled cobalamins in Streptomyces griseus grown in medium containing 57Co-cobalt chloride has been estimated by two-dimensional thin-layer chromatography and bioautography. 57Co-Methylocobalamin (Me[57Co]Cbl) was the major form in the mycelium together with smaller amounts of 57Co-adenosylcobalamin (Ado[57Co]Cbl) and 57Co-hydroxocobalamin (OH[57Co]Cbl). The OH[57Co]Cbl was detected in three forms having, respectively, anionic, cationic and neutral properties. A simple technique has been developed to isolate and purify Me[57Co]Cbl and Ado[57Co]Cbl from the mycelium using column chromatography on ion-exchange celluloses. Small quantities of each cobalamin coenzyme have been obtained at 90--96% purity and specific activities of 190--230 muCi/microgram.

Chromatography, DEAE-Cellulose↗
PubMed1975

Communicating hydrocephalus in children with genetic inborn errors of metabolism.

The authors have seen eight cases of communicating hydrocephalus in children with genetic metabolic disorders, namely, one mucopolysaccharidosis I (MPS I or Hurler syndrome), one MPS II (Hunter's disease), four MPS III (Sanfilippo syndrome) two of which were siblings, and two achondroplasias. The authors recommend surgical treatment of the latter but are doubtful about the former in which case hydrocephalus is only a contributing cause to severe dementia. In MPS hydrocephalus is due to accumulation of storage material in the piaarachnoid, as indicated by RISA cisternography carried out in six cases.

Achondroplasia↗