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Biomedical subjects

A Hamilton

Publications and source records attributed to A Hamilton.

At least 73 records · Page 4Linked to original sources
PubMed1981

Sexual problems in arthritis and allied conditions.

There is need for a greater readiness among the medical and paramedical professions to recognize the widespread occurrence of sexual problems in patients with arthritis and allied conditions. Sexual image, sexual drive, sexual competence, sexual expression, and sexual opportunity may all be adversely affected by the onset of arthritis, the type and degree of effect depending on the nature, severity, and duration of the disease and on the social and marital state of the patient. Single patients may have difficulty in forming stable sexual relationships and married patients in creating a mutually satisfying pattern of sexual expression. The physical and psychological state of patient and partner and the medication of both need careful consideration to determine contributory causes to the individual problem-complex of each patient. Based on the experience of 12 years' sexual counselling at a disabled living unit and an orthopaedic hospital, and of 4 years at a weekly clinic for disable people with sexual problems, the causes and means of amelioration of these problems are discussed.

Arthritis↗
PubMed1980

Adrenocorticotropic hormone may be transported directly from the pituitary to the brain.

Experiments were designed to test the hypothesis that pituitary hormones may be delivered directly to the brain. Concentrations of adrenocorticotropic hormone (ACTH) in the plasma were determined in blood samles obtained simultaneously from the carotid artery, the sagittal sinus, and the jugular vein of three awake sheep. Seizures were induced electrically to stimulate ACTH secretion, and at precise intervals thereafter several simultaneous comparisons were made in each animal. In many of the post-seizure comparisons, the ACTH plasma concentrations within the sagital sinus exceeded those within the carotid artery as well as those within the jugular vein, indicating that this hormone was released from the pituitary and carried directly through capillary beds of brain to the venous blood within the sagittal sinus. The experiment was repeated in one hypophysectomized sheep and, in this animal, ACTH concentration in the plasma was reduced, but that in the sagittal sinus still was elevated after the seizure, an indication that some ACTH (or ACTH-like material) was released from the brain itself.

Adrenocorticotropic Hormone↗
PubMed1979

Upper limb amputees.

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Activities of Daily Living↗
PubMed1978

Isolation of 57Co-cobalamin coenzymes at high specific activity from Streptomyces griseus.

The distribution of radio-labelled cobalamins in Streptomyces griseus grown in medium containing 57Co-cobalt chloride has been estimated by two-dimensional thin-layer chromatography and bioautography. 57Co-Methylocobalamin (Me[57Co]Cbl) was the major form in the mycelium together with smaller amounts of 57Co-adenosylcobalamin (Ado[57Co]Cbl) and 57Co-hydroxocobalamin (OH[57Co]Cbl). The OH[57Co]Cbl was detected in three forms having, respectively, anionic, cationic and neutral properties. A simple technique has been developed to isolate and purify Me[57Co]Cbl and Ado[57Co]Cbl from the mycelium using column chromatography on ion-exchange celluloses. Small quantities of each cobalamin coenzyme have been obtained at 90--96% purity and specific activities of 190--230 muCi/microgram.

Chromatography, DEAE-Cellulose↗
PubMed1975

Communicating hydrocephalus in children with genetic inborn errors of metabolism.

The authors have seen eight cases of communicating hydrocephalus in children with genetic metabolic disorders, namely, one mucopolysaccharidosis I (MPS I or Hurler syndrome), one MPS II (Hunter's disease), four MPS III (Sanfilippo syndrome) two of which were siblings, and two achondroplasias. The authors recommend surgical treatment of the latter but are doubtful about the former in which case hydrocephalus is only a contributing cause to severe dementia. In MPS hydrocephalus is due to accumulation of storage material in the piaarachnoid, as indicated by RISA cisternography carried out in six cases.

Achondroplasia↗