[Nature of competent viral particles contained in murine sarcoma virus stocks, Moloney strain].
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Animals↗
Biomedical subjects
A Hampe
Publications and source records attributed to A Hampe.
[Low molecular weight nuclear na from KB cells].
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Carcinoma↗
[Fractionation by electrophoresis on polyacrylamide gel of RNA of low molecular weight present in KB cell nuclei].
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Cell Nucleus↗
[Evidence for viral RNA in cells chronically infected with Rauscher virus].
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Centrifugation, Density Gradient↗
Early diffuse chromosome alterations in monkey kidney cells infected in vitro with herpes simplex virus.
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Animals↗
Nucleotide sequence analysis of a cloned duck beta-globin cDNA.
The primary structure of the duck beta-globin mRNA was obtained from sequence analysis of the double-stranded in vitro-transcribed DNA cloned in plasma pBR322. The 646-bp long globin DNA insert comprises a coding sequence of 438 bp corresponding to 146 amino acids, a 5'-noncoding region 63 bp long, and a 3'-noncoding region of 113 bp prior to a stretch of adenosine residues. The salient features of each of these regions are discussed and compared with beta-globin mRNAs of other vertebrates.
Animals↗
Frequent c-fms activation by proviral insertion in mouse myeloblastic leukaemias.
Retroviruses lacking oncogenes can induce tumours in animals, and the tumour cells are frequently found to contain proviral DNA inserted next to a proto-oncogene, which is thus placed under the regulatory control of the retroviral long terminal repeat (LTR). This altered regulation leads to overexpression of the proto-oncogene, which presumably contributes to the growth properties of the tumour cells. fim-2 has been described as a retroviral integration site frequently and specifically involved in murine myeloblastic leukaemias induced in vivo or in vitro by the replication-competent Friend murine leukaemia virus (F-MuLV). Here we report that fim-2 spans the 5'-end of the murine proto-oncogene c-fms, known to code for a transmembrane glycoprotein with tyrosine kinase activity probably identical to the receptor of the haemopoietic growth factor, monocyte-macrophage colony-stimulating factor (M-CSF or CSF-1). Proviral integration in the fim-2 region results in a high expression of a normal sized c-fms messenger RNA. We also observe that some tumours have lost the fim-2/c-fms germ line allele. These results provide the first evidence for the presumed involvement of c-fms in myelomonocytic leukaemias.
Animals↗
[Importance of cytochemical technics for the study of modifications of the enzyme equipment of leukocytes in leukemia].
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Histocytochemistry↗