[Nodular goiter (simple and toxic). Current states of medico-surgical treatment].
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Adolescent↗
Biomedical subjects
A Handoca
Publications and source records attributed to A Handoca.
The thyroglobulin variations during the thyroid surgery for polynodular goiter, hyperthyroidism and cancer.
A radioimmunoassay (RIA) double antibody system for human thyroglobulin (Tgl) was developed with a sensitivity of 2.5 ng/ml T3 and T4 did not interfere in the antibody Tgl binding. The blood was collected pre-, intra- and 24 hrs post-thyroidectomy from 50 females and 4 males diagnosed as polynodular goiter, hyperthyroidism, chronic thyroiditis and thyroid cancer. The ratios of the intra- and post-operatory values versus pre-operatory values were calculated. The basal values in the patients having thyroid troubles varied within very large limits (two orders of magnitude) and these values could not be clearly correlated to the thyroid pathology, However, in untreated hyperthyroid patients the basal values exceeded 100 ng/ml, while in medullary carcinoma they were near the sensitivity limit of the technique. The intra-operatory values varied within the percentual area (thyroid carcinoma), multiplicative area (polynodular goiter and some cases of hyperthyroidism) and the order of magnitude area (hyperthyroid patients and some of the polynodular goiters). The value of the RIA measurement of the Tgl in the serum as an adjuvant in the post-treatment follow up of thyroid patients is discussed.
Female↗
Cardiovascular pathology in acromegaly and some effects of the 90 yttrium implant in the hypophysis.
Examination of the cardiovascular apparatus (cv) of 25 acromegalic patients revealed an increased incidence of cardiovascular pathology as against normal individuals. Acromegalic patients with arterial hypertension (AH) show a twice higher incidence of ischemic cardiopathy, cardiomegaly with obvious or latent cardiac failure, arrhythmias, which frequently lead to death. The uncertain pathogeny of cardiomyopathy implied: hypoxia due to heart hypertrophy (over 500 g and increased cross-section of the fibre to over 26/mu), adrenergic deficiency resulting from increased protein synthesis and decrease in thyrosine, a precursor of myocardic cathecolamines. The increased incidence of coronary pathology is favoured in acromegalic patients by diabetes, hyperlipoproteinemia, low endogenous heparin, increased ureic acid and platelet adhesivity. Hypophysectomy by hypophysolysis (20 cases) brings relief and cures cardiovascular pathology, reduces AH, corrects the coronary risk factors, cures hypophyseal diabetes. The existence of AH and cardiovascular pathology is an indication for surgical treatment in evolutive acromegaly.
Acromegaly↗
Considerations on some anatomo-clinical phenomena of thyroid cancer. Treatment and prognosis. Personal experience with 1515 operated cases.
The authors present a retrospective study on 1515 histologically confirmed cases of thyroid cancer encountered along a period of 30 years of activity. These cases were found among 15,200 patients operated on for thyroid disorders. Of these 1515 cases, 1310 were differentiated carcinomas of the follicular, papillary or trabecular type, 156 nondifferentiated carcinomas and 49 medullary carcinomas. The treatment for all these forms of cancer was a complex one, depending on the clinical stage and the anatomo-pathologic form. The authors advocate total or quasi-total thyroidectomy in all the forms of differentiated cancer, followed by administration of radioactive iodine and hormones. Under these conditions, the prognosis is extremely favourable. For nondifferentiated and medullary cancer the authors propose a wide resection followed by application of X-ray or cobalt and hormonal substitution therapy. The prognosis of these cases is poor.
Humans↗
The release of LH and FSH during the thyroid surgery for hyperthyroidism.
Serial blood samples, collected from 21 females and 9 males through the thyroid surgery procedures were assayed for LH and FSH by a radioimmunoassay (RIA) technique. During thyroid surgery the serum LH increased significantly in the male patients from the preoperative levels 20.66 +/- 11.67 to 45.49 +/- 18.50 mIU/ml (p less than 0.01), being unchanged or slightly lower in the female group. The serum LH progressively fell towards the end of the surgery, remaining over the preoperative levels i4 hrs after surgery; occasionally very high levels were observed. The release of LH seemed to be more precocious during the surgery in both sexes in patients belonging to the age group under 40 years by comparison to the older group. The serum FSH showed nonsignificant changes during and after surgery in both female and male patients excepting two menopaused female hyperthyroid patients and a woman of 60 years under laborious surgery for a cervicothoracic polynodular goiter. The data are suggesting the dissociated secretion of LH and FSH in both sexes excepting some cases of menopaused women.
Adolescent↗