Biomedical subjects
Publications and source records attributed to A Hanen.
On a theoretical model of cellular genome we demonstrate that the clonal multiplication induces an ineluctable decline of the "mitotic capacity". A cellular population is formed, the genomes of which include no more than one of each fundamental genetic element.
We define a theoretical model for clonal reproduction and we describe how the accumulation of mutations induces an ineluctable decline of the "mitotic capacity". During the vital cycle of organisms, meïosis and fecundation may have the function of making up for this fall. This should allow us to understand the temporal structure or the sexualisation of the vital cycle as well as some peculiarities of the spatial structure of the genome.
By means of the most used methods at present of time series analysis, the authors describe a modular package allowing a non-specialised user to process by himself experimental results. Probability sets may be calculated, drawn and statistically tested from direct or transformed data. The use of this package is made easier by means of an automation table which chooses the necessary parameters and memorises responses so as to avoid superfluous problems. The FORTRAN IV coded program is run on a PDP 10 under time-sharing for the analysis of the data concerning action potentials in neurophysiology.